Comparison of Fiber Diameter Distributions Deduced by Modeling Compound Action Potentials Recorded by Extracellular and Suction Techniques

Dalkılıç, Nizamettin; Pehlivan, Ferit

doi:10.1080/00207450290025923

Cited by 25 publications

(29 citation statements)

References 14 publications

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“…This is complementary information that supports our previous studies. 17) The change in latency periods and the time elapsed between pulse artifact and CAP onset, were also measured in order to evaluate the eŠects of collagenase on fast conductingˆbers. The change in the latency of nCAPs and cCAPs with distance are both linear and given in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…17,18,20) The weighting coe‹cients (w i ) are general parameters to account for all in‰uences on the contribution of eachˆber class to the observed CAP.…”

Section: Methodsmentioning

confidence: 99%

“…17,18) To obtain the individual nerveˆber activity, a conduction velocity distribution histogram was developed using the mathematical model that we have enhanced 17) and taking the model proposed by Cummins et al 19) as a base. The basic principle of our model is based on the statements of CAP, and can be expressed as…”

Section: Methodsmentioning

confidence: 99%

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Does Collagenase Affect the Electrophysiological Parameters of Nerve Trunk?

et al. 2003

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Collegenase is widely used in the process of teasing a nerve in order to perform singleˆber action potential (SFAP) recordings. In this study, the eŠects of collagenase on nerve conduction parameters were investigated. To accomplish this, normal compound action potentials (nCAPs) were recorded from isolated frog sciatic nerve at various distances using the suction technique. Then, the same nerve was treated with collagenased Ringer's solution (3.5 mg/ml, Sigma Type XI) for 90 minutes and action potentials (cCAPs) were recorded again. Numerical analysis of these records was performed and the results were compared. Using the nCAP and cCAP recordings, the conduction velocity distributions (CVD) of the individual nerve trunks were determined by a method that we have previously described. Statistical results indicated signiˆcant diŠerences ( p＜0.05) between the nCAP and cCAP CVD data. From theseˆndings it is concluded that, when used for teasing the nerveˆbers, collagenase may aŠect the nerve trunk conduction parameters. Speciˆcally, a signiˆcant amount of decrease has been observed in conduction velocities of myelinatedˆbers having diameters smaller than 8 mm.

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Section: Resultsmentioning

confidence: 99%

“…17,18,20) The weighting coe‹cients (w i ) are general parameters to account for all in‰uences on the contribution of eachˆber class to the observed CAP.…”

Section: Methodsmentioning

confidence: 99%

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Does Collagenase Affect the Electrophysiological Parameters of Nerve Trunk?

et al. 2003

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“…To obtain the individual nerveˆber activity, a conduction velocity distribution histogram was developed using the mathematical model that we have enhanced. 6,12) Our model based on the model The graph legends represent tramadol concentration. As the tramadol concentration is increased, CAP amplitude decreased and latency is increased.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Tramadol on the Rat Sciatic Nerve Conduction: A Numerical Analysis and Conduction Velocity Distribution Study

Dalkılıç¹,

Tuncer²,

Barışkaner³

et al. 2009

YAKUGAKU ZASSHI

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The aim of this study was to document the eŠect of tramadol as an opioid on individualˆbers of rat sciatic nerve. To accomplish this objective, compound action potentials (CAPs) were recorded from isolated nerves treated with tramadol fromˆve diŠerent concentration levels. Then recorded CAPs and the control group were analyzed by numerical methods namely Conduction Velocity Distribution (CVD) and Fast Fourier Transform (FFT). The results show that the area under CAP and the time derivative of CAP curves decreases, and the excitability of the nerve trunk falls as well (rheobase and chronaxie increases) with increasing tramadol concentration. CVD deduced by model study was divided into subgroups as SLOW (8 26 m/s), MODERATE (26 44 m/s), MEDIUM (44 60 m/s) and FAST (60 78 m /s). The decrement in percentage relative contribution of these conduction velocity groups starts with a concentration of 0.25 mM tramadol, especially in the subgroup named FAST. The power spectrum shifts from higher frequency region to lower frequency region as the tramadol concentration increases. Theseˆndings show that fast conductingˆbers are more susceptible to tramadol than medium and moderate groups and tramadol possibly acts on channel activity rather than passive properties (such as space and time constant) of nerveˆbers.

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“…It is a first-order analytical model of the extracellular AP and is based on a damped sinusoidal function as proposed in [13], [20].…”

Section: A Single Fiber Action Potential Modelmentioning

confidence: 99%

A New Method for Neural Spike Alignment: The Centroid Filter

Metcalfe

Clarke

Donaldson

et al. 2017

IEEE Trans. Neural Syst. Rehabil. Eng.

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Highlights A key problem in neural spike sorting is highlighted.  A new method to measure the position of action potentials in real-time is described.  This method is validated using detailed simulations. Major improvements are demonstrated compared to standard methods. AbstractBackground: This paper describes a new method to calculate the positions of action potentials (APs) in extracellular neural recordings in real-time. Extracellular recordings made using various types of electrode structures are a key tool in experimental electrophysiology and involve the identification of signals from individual neurons, a process known by the generic name spike sorting. An essential feature of the process is the alignment of individual APs ('spikes') in time. Given the recordings are invariably made in noisy environments there is a tendency to timing jitter leading to alignment errors. This is especially true if single point methods of AP location are employed. New Method: The problems of single point AP location in the presence of noise are significantly reduced by the use of the centroid as a measure of position, which is based on a time average of all the points in the AP. The method is described and analysed in detail and it is shown that a very economical hardware realisation is possible. Results:The new methods are investigated by simulation using deterministic models of nerve signals (i.e. APs with added noise; both correlated and uncorrelated noise models are considered) as well as results measured from a hardware implementation. A power efficient realisation of the centroid filter is demonstrated using a complex programmable logic device (CPLD). Comparison with Existing Method:Detailed simulations demonstrate the superiority of the centroid method compared to several standard, single point metrics. Conclusions: A new method has been suggested that significantly improves one of the key issues in neural spike sorting. The technique has the potential to influence significantly the design of electrophysiological recording systems in the future.

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Comparison of Fiber Diameter Distributions Deduced by Modeling Compound Action Potentials Recorded by Extracellular and Suction Techniques

Cited by 25 publications

References 14 publications

Does Collagenase Affect the Electrophysiological Parameters of Nerve Trunk?

Does Collagenase Affect the Electrophysiological Parameters of Nerve Trunk?

The Effect of Tramadol on the Rat Sciatic Nerve Conduction: A Numerical Analysis and Conduction Velocity Distribution Study

A New Method for Neural Spike Alignment: The Centroid Filter

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