Comparison of fibrinolysis and coagulation in Nigerian and European men

Howell, Margaret

doi:10.1016/s0368-1319(65)80011-4

Cited by 18 publications

(4 citation statements)

References 30 publications

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“…51,56 The comparative study on a group of Nigerian and European men confirmed these findings. 57,58 Similar trends have been reported in Gambia and Uganda.…”

Section: Trends In Cad Insupporting

confidence: 77%

Trends in coronary artery disease and associated risk factors in sub-Saharan Africans

Akinboboye

Idris²,

Akinkugbe

2003

J Hum Hypertens

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It has been suggested that the prevalence of coronary artery disease (CAD) is steadily increasing in subSaharan Africa. To address this issue, we conducted a Medline search of English language articles on cardiovascular diseasesFand specifically CAD in AfricaF from 1966 to 1997. The prevalence of CAD and related complications is relatively low in most regions in Africa compared to that obtained in the economically developed countries, although the situation is rapidly changing due to trends in urbanization, changes in lifestyle, acquisition of technology and the increasing numbers of tertiary care institutions. There are variations in reported prevalence rates within the different regions, but there is an upward trend in all the regions of the sub-Saharan Africa. This trend is believed to be related to the increasing frequencies of CAD risk factors in the subcontinent.

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“…51,56 The comparative study on a group of Nigerian and European men confirmed these findings. 57,58 Similar trends have been reported in Gambia and Uganda.…”

Section: Trends In Cad Insupporting

confidence: 77%

Trends in coronary artery disease and associated risk factors in sub-Saharan Africans

Akinboboye

Idris²,

Akinkugbe

2003

J Hum Hypertens

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“…The Melanesian anti-plasmin activity was shown to be Significantly less both in serum and in plasma, using two techniques. Comparative studies between ethnic groups are sparse in the literature, but that of Howell (1965) comparing Nigerians with Europeans showed a similar difference in inhibition to that reported here! The statistical correlation of prothronibin times and saline fibrinogen titres suggested that iiz vitro digestion of coagulation factors by plasmin might be responsible for the findings.…”

Section: Discussionsupporting

confidence: 72%

Comparisons of Fibrinolysis and Blood Coagulation in Melanesians and Caucasians

Booth¹,

MacGregor²

1967

Br J Haematol

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SUMMARY Investigations carried out in Port Moresby, Territory of Papua and New Guinea, on blood coagulation and fibrinolysis are described. Significant differences (P < 0.01) were found when comparing Melanesians with Caucasians, in that the former show decreased plasmin inhibition, increased and accelerated plasminogen activation and prolonged prothrombin times. Total plasminogen levels are similar in the two ethnic groups compared. The possible roles of liver disease and vitamin K deficiency in the causation of prolonged prothrombin times in Melanesians merit further study. It is concluded from the results that compared to Caucasian males resident in the Tropics, Melanesian males have a less labile or more potent plasminogen activator system, and also a relative lack of anti‐plasmin. These differences might account for the increased incidence of hyperplasminaemia in the indigenous population, and possibly are relevant to their comparative freedom from atheromatous and thrombo‐embolic occlusive vascular disease.

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“…Previous ethnic studies using a variety of PT techniques have shown some disagreement. Whereas Merskey et al (L7) did not find the PT significantly different between South African Bantus and whites, Howell (18) and Barr et al (19), in studies in Nigeria and Kenya, respectively, reported longer PT in black compared with white subjects. A lower factor VII level in black males in London was reported by Meade et al (21) but not in black females.…”

Section: Discussionmentioning

confidence: 90%

Differences in Coagulation and Haemostatic Parameters in Normal Women of Childbearing Age from Different Ethnic Groups and Geographical Locations

Ja¹,

Barja²,

Bonnar

et al. 1986

Thromb Haemost

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SummaryA comparative study of coagulation and fibrinolytic laboratory parameters was undertaken in four countries (Salvador, Brazil; Singapore; Santiago, Chile and Dublin, Ireland) among apparently healthy women of reproductive age. A continuous external quality control scheme of the laboratory measurements was employed to permit comparison among centres. Significant and consistent differences were found between the four centres. In Dublin, the prothrombin time and activated partial thromboplastin time (APTT) were accelerated, and the specific factor assays showed more activity, whereas the antiprotease levels were higher than in the other centres. In Salvador, a contrasting tendency was found with longer prothrombin times and APTT and lower Factor VII and antiprotease levels. The results from the other two centres were approximately midway between these two extremes. The study has revealed important differences in the coagulation and haemostatic tests between women from widely diverse geographical areas. It is not certain whether these are due to ethnic, nutritional or economic factors but they may be related to the apparent varying incidence of thrombosis in these ethnic groups.

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Comparison of fibrinolysis and coagulation in Nigerian and European men

Cited by 18 publications

References 30 publications

Trends in coronary artery disease and associated risk factors in sub-Saharan Africans

Trends in coronary artery disease and associated risk factors in sub-Saharan Africans

Comparisons of Fibrinolysis and Blood Coagulation in Melanesians and Caucasians

Differences in Coagulation and Haemostatic Parameters in Normal Women of Childbearing Age from Different Ethnic Groups and Geographical Locations

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