Comparison of findings using ultrasonography and cystoscopy in urogenital schistosomiasis in a public health centre in rural Angola

Santos, Jorge; Chaves, J.S.I.; Araújo, Heriberto; Vale, Nuno; Costa, José Manuel Correia da; Brindley, Paul J.; Lopes, Cláudia B.; Naples, Jean M.; Shiff, Clive; Dupret, Jorge; Santos, Lúcio Lara

doi:10.7196/samj.8564

Cited by 13 publications

(12 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study in Angola, Bocanegra et al (2018) [104] followed up 70 SAC by ultrasound scanning 6-8 months after praziquantel medication. Their images showed improvement in 53 SAC (75.7%), no changes in 12 (17.1%), and progression in 5 (7.1%) [105]. The use of ultrasound allows for the practical and beneficial management of infected cases of UGS by providing non-invasive and safe screening of the pathological consequences and outcomes after medication.…”

Section: Ultrasound Scanningmentioning

confidence: 99%

“…The use of ultrasound allows for the practical and beneficial management of infected cases of UGS by providing non-invasive and safe screening of the pathological consequences and outcomes after medication. Santos et al (2015) [105] compared ultrasound images and cystoscopy findings of 80 subjects with UGS in Angola. They highlighted the diagnostic significance of identifying the distorted shape of the urinary bladder [105].…”

Section: Ultrasound Scanningmentioning

confidence: 99%

See 1 more Smart Citation

Review of Recent Prevalence of Urogenital Schistosomiasis in Sub-Saharan Africa and Diagnostic Challenges in the Field Setting

Hong

2023

Life

View full text Add to dashboard Cite

Human schistosomiasis is one of neglected tropical diseases that remain highly prevalent in sub-Saharan Africa (SSA). Human schistosomiasis is mainly caused by two species, Schistosoma haematobium and S. mansoni, leading to urogenital and intestinal schistosomiasis, respectively. The World Health Organization (WHO) recommends mass drug administration (MDA) with praziquantel as the primary method of global intervention. Currently, MDA with praziquantel covers over half of the target population in endemic SSA countries. However, an accurate diagnosis is crucial for monitoring and evaluating the effectiveness of MDA. The standard diagnosis of both urogenital and intestinal schistosomiasis relies on the microscopic identification of eggs. However, the diagnostic sensitivity of this approach is low, especially for light or ultra-light infections. This is because Schistosoma eggs are laid inside of the venous plexus of the urinary bladder or mesenteric vein, where the adult flukes live. Approximately half of the eggs circulate in the blood vessels or are packed in neighboring tissues, while the remaining half are expelled into the lumen of the urinary bladder or intestine intermittently when the blood vessels are ruptured. In the field setting, the accuracy of any diagnostic method is critical for proper management of the intervention. The present article reviews the recent prevalence of urogenital schistosomiasis in SSA and highlights the practical limitations of diagnostic methods such as urine microscopy, urine reagent strips, molecular diagnosis, and ultrasound scanning in the field setting. Despite continuous global efforts to eliminate schistosomiasis over the past 20 years, many areas still remain endemic in SSA. No single diagnostic approach achieves acceptable sensitivity and specificity in the field setting. Therefore, any field survey should employ a combination of these methods based on the purpose of the study to accurately monitor and evaluate urogenital schistosomiasis. Based on diagnostic values and a cost–benefit analysis, a urine reagent strip test can replace urine microscopy in the field setting. The WHO criteria by ultrasound diagnosis should be updated including the echogenic snow sign and contour distortion.

show abstract

Section: Ultrasound Scanningmentioning

confidence: 99%

Section: Ultrasound Scanningmentioning

confidence: 99%

Review of Recent Prevalence of Urogenital Schistosomiasis in Sub-Saharan Africa and Diagnostic Challenges in the Field Setting

Hong

2023

Life

View full text Add to dashboard Cite

show abstract

“…Urogenital schistosomiasis (UGS) is a chronic inflammation-mediated disease. The continuous inflammatory reaction to the eggs leads to parenchymal tissue destruction, fibrosis, granulomata, and ultimately, to fibrotic nodules termed sandy patches [ 38 , 40 ]. The eggs retained due to chronic infection release H03-H-IPSE, a major ortholog of the interleukin-4-inducing principle (IPSE); this nuclear protein is related to urothelial cell proliferation in mouse models.…”

Section: Helminths Involved In Cancermentioning

confidence: 99%

Roles of microRNAs and Long Non-Coding RNAs Encoded by Parasitic Helminths in Human Carcinogenesis

Leija-Montoya

González-Ramírez

Martínez-Coronilla

et al. 2022

IJMS

View full text Add to dashboard Cite

Infectious agents such as viruses, bacteria, and parasites can lead to cancer development. Infection with the helminthic parasite Schistosoma haematobium can cause cancer of the urinary bladder in humans, and infection with the parasites Clonorchis sinensis and Opisthorchis viverrini can promote cholangiocarcinoma. These three pathogens have been categorized as “group 1: carcinogenic to humans” by the International Agency for Research on Cancer (IARC). Additionally, the parasite Schistosoma japonicum has been associated with liver and colorectal cancer and classified as “group 2B: possibly carcinogenic to humans”. These parasites express regulatory non-coding RNAs as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), which modulate genic expression in different biological processes. In this review, we discuss the potential roles of miRNAS and lncRNAs encoded by helminthic parasites that are classified by the IARC as carcinogenic and possibly carcinogenic to humans. The miRNAs of these parasites may be involved in carcinogenesis by modulating the biological functions of the pathogen and the host and by altering microenvironments prone to tumor growth. miRNAs were identified in different host fluids. Additionally, some miRNAs showed direct antitumoral effects. Together, these miRNAs show potential for use in future therapeutic and diagnostic applications. LncRNAs have been less studied in these parasites, and their biological effects in the parasite–host interaction are largely unknown.

show abstract

“…Discussion S. haematobium has been considered as a de nite carcinogen for human (group 1 carcinogens) [22], the chronic infection with S. haematobium eventually leads to squamous cell carcinoma of the urinary bladder [23]. Genetic alterations, chromosomal aberrations, and cytological changes have been described in schistosome-associated urinary bladder carcinomas [24][25][26]. It is generally believed that schistosomiasis causes chronic irritation and in ammation in the bladder, which can promote changes in at least two stages of disease development: rstly, the onset of precancerous lesions, and secondly, acting as a promoter to increase the likelihood of the transformation of these lesion into malignant status [25].…”

Section: Survival Analysismentioning

confidence: 99%

Increased MET Copy Number and its Differing Prognostic Values in Schistosomal and Non-Schistosomal Colorectal Cancers

Pan

Luan

Huang

et al. 2022

Preprint

View full text Add to dashboard Cite

Objective: To compare the prognostic role regarding gene copy number alteration of MET in schistosomal colorectal cancer (SCRC) and non-schistosomal colorectal cancer (NSCRC).Methods: This retrospective study included 131 SCRC and 207 NSCRC patients, MET status was evaluated by fluorescent in situ hybridization (FISH) and immunohistochemistry (IHC) in tissue microarray sections.Results: No significant differences were found in terms of clinical characteristics for SCRC patients and NSCRC patients except for age, where significantly more patients over 60 years old presented SCRC than NSCRC (P < 0.001). 10.0% of cases were MET FISH-positive (mean ≥ 3 copies/cell). MET protein expression was positive in 60.3% of cases, but was not associated with MET FISH-positive (P = 0.574). All patients were followed, and the median time was 51.3 months (range, 1.0 – 134.4 months). The prognostic significance of MET FISH-positive was different between SCRC and NSCRC. In SCRC, patients that were MET FISH-positive had significantly shorter survival compared to those that were MET FISH-negative (P = 0.014). In NSCRC, the overall survival shows a slight trend toward favorable prognosis in association with MET FISH-positive for stage I-II patients (P = 0.138), yet MET FISH-positive were significantly correlated to adverse survival for stage III-IV patients (P = 0.015). Conclusions: Increased MET copy number acts as a negative prognostic factor for SCRC, which has bidirectional prognostic significance in NSCRC.

show abstract

Comparison of findings using ultrasonography and cystoscopy in urogenital schistosomiasis in a public health centre in rural Angola

Cited by 13 publications

References 15 publications

Review of Recent Prevalence of Urogenital Schistosomiasis in Sub-Saharan Africa and Diagnostic Challenges in the Field Setting

Review of Recent Prevalence of Urogenital Schistosomiasis in Sub-Saharan Africa and Diagnostic Challenges in the Field Setting

Roles of microRNAs and Long Non-Coding RNAs Encoded by Parasitic Helminths in Human Carcinogenesis

Increased MET Copy Number and its Differing Prognostic Values in Schistosomal and Non-Schistosomal Colorectal Cancers

Contact Info

Product

Resources

About