Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial

Ozolins, Mara; Eady, E. Anne; Avery, Anthony J; Cunliffe, W. J.; Po, A. Li Wan; O’Neill, Ciarán; Simpson, N. B.; Walters, C.E.; Carnegie, Ellen; Lewis, Jennifer B; Dada, John; Haynes, Michelle; Williams, Karen; Williams, Hywel C

doi:10.1016/s0140-6736(04)17591-0

Cited by 152 publications

(100 citation statements)

References 22 publications

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“…39,40 So far, antibiotic resistance to BP has not been reported. [41][42][43][44] Although issues regarding genotoxicity have been raised in the past, BP has now been labeled as "GRASE" (generally regarded as safe and effective) by the FDA, and all topical monotherapy products have been made available OTC since 2011. Labeling includes advice to avoid the eyes, lips, and mouth.…”

Section: Over-the-counter Treatment Optionsmentioning

confidence: 99%

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

et al. 2013

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INTRODUCTION: Acne vulgaris is one of the most common skin conditions in children and adolescents. The presentation, differential diagnosis, and association of acne with systemic pathology differs by age of presentation. Current acknowledged guidelines for the diagnosis and management of pediatric acne are lacking, and there are variations in management across the spectrum of primary and specialty care. The American Acne and Rosacea Society convened a panel of pediatric dermatologists, pediatricians, and dermatologists with expertise in acne to develop recommendations for the management of pediatric acne and evidence-based treatment algorithms. METHODS: Ten major topic areas in the diagnosis and treatment of pediatric acne were identified. A thorough literature search was performed and articles identified, reviewed, and assessed for evidence grading. Each topic area was assigned to 2 expert reviewers who developed and presented summaries and recommendations for critique and editing. Furthermore, the Strength of Recommendation Taxonomy, including ratings for the strength of recommendation for a body of evidence, was used throughout for the consensus recommendations for the evaluation and management of pediatric acne. Practical evidence-based treatment algorithms also were developed. RESULTS: Recommendations were put forth regarding the classification, diagnosis, evaluation, and management of pediatric acne, based on age and pubertal status. Treatment considerations include the use of over-the-counter products, topical benzoyl peroxide, topical retinoids, topical antibiotics, oral antibiotics, hormonal therapy, and isotretinoin. Simplified treatment algorithms and recommendations are presented in detail for adolescent, preadolescent, infantile, and neonatal acne. Other considerations, including psychosocial effects of acne, adherence to treatment regimens, and the role of diet and acne, also are discussed. CONCLUSIONS: These expert recommendations by the American Acne and Rosacea Society as reviewed and endorsed by the American Academy of Pediatrics constitute the first detailed, evidence-based clinical guidelines for the management of pediatric acne including issues of special concern when treating pediatric patients.

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Section: Over-the-counter Treatment Optionsmentioning

confidence: 99%

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

et al. 2013

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“…41 Indeed, in the last decade, bacteria resistance to antibiotics, macrolides and tetracyclines, 42,43 but also rifampicin, 44 has dramatically increased, leading to a renewed interest in nonantibiotic treatments. 45 We have also observed an improvement of acne lesions, with a 42% and 19% reduction in the score of inflammatory and retentional lesions, respectively, at D56.…”

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confidence: 99%

Characterisation of Cutibacterium acnes phylotypes in acne and in vivo exploratory evaluation of Myrtacine^®

Pécastaings

Roques

Nocera

et al. 2018

Acad Dermatol Venereol

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Objective Our main objective was to compare Cutibacterium acnes (C. acnes) skin colonisation in patients with mild to moderate acne versus healthy controls and secondly, to evaluate a Myrtacine â -based cream on C. acnes total population and antibioresistant Cutibacteria in patients with acne.Methods In 60 acne patients (Global Acne Severity Scale, GEA grades 2-3), of mean age 20 [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Results We first showed (i) high and similar levels of C. acnes colonisation in superficial pilosebaceous follicles and detection of EryR and ClnR strains in both acne and control groups; (ii) different repartition of phylotypes in acne patients versus healthy control, with a predominance of phylotype IA in acne patients and a link between phylotype IA and erythromycin resistance. Besides, after treatment with the Myrtacine â -based cream in acne patients, there was no change in C. acnes total load, but a significant decrease of EryR Cutibacteria, reduced porphyrin production by C. acnes, a decrease in acne severity (GEA), associated with reduced retentional and inflammatory lesions.Conclusion Cutibacterium acnes colonisation was not significantly different in acne versus control groups. Phylotype IA was predominant in acne patient and in EryR C. acnes. A Myrtacine â -based cream significantly reduced the level of EryR Cutibacteria in vivo and improved acne lesions.

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“…1,5 Monotherapy with BPO has been shown to be as effective as an association of BPO with topical or oral antibiotics. 9 In 2010, Seidler and Kimball conducted a meta-analysis in which they compared the efficacy of 5% BPO, 1% to 1.2% clindamycin, 5%…”

Section: Resultsmentioning

confidence: 99%

“…6,12 In cases of acne, monotherapy with topical antibiotics is contraindicated due to the possibility of inducing bacterial resistance, which is related to worsened therapeutic responses and relatively slow onset of action compared with other antimicrobial regimens used in treating acne. 1,4,9,12 In a systematic review carried out in 2008, Simonart and Draimax analyzed RCTs on therapeutic interventions for acne.…”

Section: Resultsmentioning

confidence: 99%

Evidence on acne therapy

Costa

Bagatin

2013

Sao Paulo Med. J.

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Among the current treatments available for acne vulgaris, many widely practiced options lack support from studies at the best level of scientific evidence. The aim of this narrative review was to present the very latest information on topical and systemic treatments for acne vulgaris. Information from systematic reviews and well-designed clinical trials, obtained through a systematic search of the major medical databases, is emphasized. There are important issues regarding the clinical management of acne that still lack consistent grounding in scientific evidence. Among these are the optimum dose and duration of treatment with oral antibiotics that can be given without inducing bacterial resistance, and the safety of oral isotretinoin. RESUMONa terapêutica atual da acne vulgar, muitas opções amplamente praticadas carecem de respaldo em estudos de melhor nível de evidência científica. O objetivo desta revisão narrativa é apresentar o que há de mais recente no tratamento tópico e sistêmico da acne vulgar. São enfatizadas as informações de revisões sistemáticas e de ensaios clínicos com bom desenho metodológico, obtidas a partir de busca sistematizada nas principais bases de dados em medicina. Há importantes questões referentes à conduta clínica diante da acne que ainda requerem embasamento em evidências científicas consistentes, entre elas a dose e a duração ideais do tratamento com antibióticos orais, sem que ocorra indução de resistência bacteriana, e a segurança da isotretinoína oral.I MD. Doctoral student in the Postgraduate

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Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial

Cited by 152 publications

References 22 publications

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

Characterisation of Cutibacterium acnes phylotypes in acne and in vivo exploratory evaluation of Myrtacine^®

Evidence on acne therapy

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Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial

Cited by 152 publications

References 22 publications

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

Characterisation of Cutibacterium acnes phylotypes in acne and in vivo exploratory evaluation of Myrtacine®

Evidence on acne therapy

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Product

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Characterisation of Cutibacterium acnes phylotypes in acne and in vivo exploratory evaluation of Myrtacine^®