Comparison of fixed‐beam IMRT, helical tomotherapy, and IMPT for selected cases

Abstract

A growing number of advanced intensity modulated treatment techniques is becoming available. In this study, the specific strengths and weaknesses of four techniques, static and dynamic multileaf collimator (MLC), conventional linac-based IMRT, helical tomotherapy (HT), and spot-scanning proton therapy (IMPT) are investigated in the framework of biological, EUD-based dose optimization. All techniques were implemented in the same in-house dose optimization tool. Monte Carlo dose computation was used in all cases. All dose-limiting, normal tissue objectives were treated as hard constraints so as to facilitate comparability. Five patient cases were selected to offer each technique a chance to show its strengths: a deep-seated prostate case (for 15 MV linac-based IMRT), a pediatric case (for IMPT), an extensive head-and-neck case (for HT), a lung tumor (for HT), and an optical neurinoma (for noncoplanar linac-based IMRT with a miniMLC). The plans were compared by dose statistics and equivalent uniform dose metrics. All techniques delivered results that were comparable with respect to target coverage and the most dose-limiting normal tissues. Static MLC IMRT struggled to achieve sufficient target coverage at the same level of dose homogeneity in the lung case. IMPT gained the greatest advantage when lung sparing was important, but did not significantly reduce the risk of nearby organs. Tomotherapy and dynamic MLC IMRT showed mostly the same performance. Despite the apparent conceptual differences, all four techniques fare equally well for standard patient cases. The absence of relevant differences is in part due to biological optimization, which offers more freedom to shape the dose than do, e.g., dose volume histogram constraints. Each technique excels for certain classes of highly complex cases, and hence the various modalities should be viewed as complementary, rather than competing.

The Potential Benefit of Radiotherapy with Protons in Head and Neck Cancer with Respect to Normal Tissue Sparing: A Systematic Review of Literature

“…In general, the dose to OARs could be substantially lower, in particular to the parotid glands [15][16][17][18][19]21], the larynx [19,21], and the spinal cord [16,19,20]. In one study, no difference was noted among three-, five-and nine-field scanning IMPT [18].…”

“…We identified seven studies reporting on ISPC studies among patients with oropharyngeal, hypopharyngeal, and laryngeal carcinoma, including a total of 22 patients [15][16][17][18][19][20][21] (Table 3). In one study, only 3D-CRT using parallelopposed fields was compared with 3D-CPT [15].…”

Comparison of different adjuvant radiotherapy approaches in childhood bladder/prostate rhabdomyosarcoma treated with conservative surgery

“…Although IMPT is able to provide favorable dose distributions [23,30,31,46], the clinical data for IMPT in children with sarcoma are very limited [29]. Timmermann et al [45] reported about IMPT for one case with BP-RMS.…”

Overestimation of Low-Dose Radiation in Intensity-Modulated Radiotherapy with Sliding-Window Technique

“…IMRT offers a method of delivering radiation dose conformed to the shape of specific targets while minimizing the dose to the surrounding tissue and nearby critical organs [7,10]. When using the sliding-window technique (Varian Medical Systems, Palo Alto, USA), the MLC leaf pairs sweep over a field during beam-on.…”