Comparison of flunixin meglumine and meloxicam influence on postoperative and oxidative stress in ovariohysterectomized bitches

Yilmaz, Oktay; Korkmaz, Musa; Jaroszewski, Jerzy Jan; Yazici, Ebubekir; Ulutaş, Elmas; Saritaş, Zülfikar Kadir

doi:10.2478/pjvs-2014-0071

Cited by 16 publications

(20 citation statements)

References 38 publications

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“…Our results show that plasma cortisol levels in the treatment groups were significantly lower than in the control group at 0-6 h as well as at 12 h post-extubation (Figure 3). One previous study demonstrated that ovariohysterectomy is a noxious stimulus in dogs, causing marked elevations in plasma cortisol for 6-12 h (Hansen et al 1997), and other studies have shown that post-operative cortisol levels were higher in dogs when meloxicam was used (Tsai et al 2013;Yilmaz et al 2014). All these results were consistent with our data.…”

Section: Discussionsupporting

confidence: 93%

Tolfenamic acid and meloxicam both provide an adequate degree of postoperative analgesia in dogs undergoing ovariohysterectomy

Hu¹,

Luan²,

Guan³

et al. 2017

Vet. Med. - Czech

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This study was aimed at comparing the postoperative analgesic effects of tolfenamic acid and meloxicam in dogs undergoing ovariohysterectomy. Ovariohysterectomy was performed in 24 female dogs. All dogs were administered pre-anaesthetic medication comprised of 0.02 mg/kg i.m. acepromazine, and general anaesthesia was induced with i.v. propofol (4-6 mg/kg) and maintained with 1.5-2.0% isoflurane. Dogs were divided into three groups (n = 8). Following induction of anaesthesia, group C received 0.05 ml/kg sterile saline i.m.; group T received 4 mg/kg tolfenamic acid i.m.; group M received 0.2 mg/kg meloxicam s.c. Heart rate, respiratory rate, rectal temperature, mean arterial pressure and arterial oxygen saturation of haemoglobin were monitored intraoperatively. Pain was assessed using the short form of the Glasgow composite pain scale (SF-GCPS) by two observers who were blinded to the treatment groups; pain was assessed at the time of pre-medication (baseline), and at 2, 4, 6, 8, 12 and 24 h after extubation. Rescue analgesia (0.2 mg/kg i.m. methadone) was administered to any dog with an SF-GCPS score of greater than or equal to six during postoperative monitoring. The pain score in group C was significantly higher compared with group T and group M at 4, 6 and 8 h, while there were no significant differences between the two treatment groups. The mean pain score in group C was also higher than that in group M at 2 h. Rescue analgesia was first administered at 4 h in group C. Rescue analgesia was required by significantly more dogs in group C (n = 8) compared with groups T (n = 0) and M (n = 1), but there was no significant difference between the two treatment groups. Thus, tolfenamic acid and meloxicam provide adequate postoperative analgesia to similar degrees over 24 h in healthy dogs undergoing ovariohysterectomy.

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Section: Discussionsupporting

confidence: 93%

Tolfenamic acid and meloxicam both provide an adequate degree of postoperative analgesia in dogs undergoing ovariohysterectomy

Hu¹,

Luan²,

Guan³

et al. 2017

Vet. Med. - Czech

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“…Clearly, BP has rapidly decreased the concentration of cortisol which reaches its level 30 minutes after the end of surgery [16]. The present study showed that cortisol levels were elevated in all groups and this finding was consistent with other reports [9,16,31]. On the other hand, the concentrations of cortisol rapidly decreased in BP and LP groups with respect to the control group.…”

Section: Discussionsupporting

confidence: 92%

“…Environmental changes, anaesthesia and surgical procedures comprise a response originated from the hypothalamic -pituitary -adrenal axis and the most important indicators of surgical stress are the changes in the blood levels of the cortisol hormone [11,12,29]. Devitt et al [9] reported that levels of cortisol increased until 2 h after standard or laparoscopic OHE in bitches, whereas Yilmaz et al [31] stated that the increment of the concentrations of cortisol was observed for 2.5 h in dogs following standard OHE. Clearly, BP has rapidly decreased the concentration of cortisol which reaches its level 30 minutes after the end of surgery [16].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Intraperitoneal and Incisional Bupivacaine or Levobupivacaine for Postoperative Analgesia in Ovariohysterectomized Dogs

Korkmaz

Yilmaz

Saritaş

et al. 2019

Acta Scientiae. Vet.

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Background: Ovariohysterectomy (OHE) is the most commonly performed elective surgical procedure in companion animals. OHE offers benefits of control of population and decreased risk of potentially life-threatening diseases such as mammarian tumours and pyometra. Traditional OHE intervention causes inflammation and pain due to trauma during organ manipulation. The purpose of this study was to compare the effect of intraperitoneal and incisional administration of bupivacaine (BP) or levobupivacaine (LP) on postoperative analgesia in dogs undergoing the OHE procedure. Materials, Methods & Results:A total of 24 mix-breed bitches aged between 1 -3 years and weighed 19 -20 kg were used in this study. The animals were divided into three groups as control (n = 8), BP (n = 8) and LP group (n = 8). The animals were kept under surveillance at the hospitalisation unit of the animal hospital for one day before the elective OHE. The dogs were fasted for 12 h before the surgery, with adlib water consumption. Atropine sulphate 0.045 mg/kg was administered subcutaneously approximately 30 min before general anaesthesia. Midazolam (0.3 mg/kg) was intravenously injected into all dogs for pre-anaesthetic medication. After sedation, anaesthesia was induced with propofol (4 mg/kg, IV) and then the dogs were orotracheally intubated using cuffed endotracheal tubes. General anaesthesia was maintained by administration of 2% isoflurane. The ventral abdomen was prepared aseptically for OHE following the general anaesthesia. All animals were operated on by the same surgeon. During surgery, sprayed bupivacaine 0.5% (4.4 mg/kg) with an equal volume of saline in BP group, levobupivacaine 0.5% (4.4 mg/kg) with an equal volume of saline in LP were then applied over the ovaries, uterine broad ligaments and cervix uteri. After removal of the uterine body, either LP or BP was sprayed to left and right, or cranial and caudal parts of the abdominal cavity. Finally, the incision line was sprayed before closing the skin. The control group received only sprayed saline. The pain evaluation was carried out with modified Melbourne pain scoring scale. To determine cortisol concentrations, blood samples were taken before anaesthesia induction (baseline) and postoperative 0, 0.5, 1, 2, 4, 6, 12 and 24 h. Postoperative pain scores were higher in the control group than BP and LP groups following surgery at 30 min, 1st, 4th, and 6th h. In all groups, cortisol levels increased postoperatively, whereas they decreased more rapidly in BP and LP groups. There was a steady increase at postoperative 0 min, 30 min, 1st, 2nd, 4th and 6th h in the control group and at postoperative 0 min, 30 min and 1 h in BP and LP groups (P < 0.05). Discussion: Intraperitoneal and incisional bupivacaine shows significantly superior postoperative pain management benefits after the closure of skin, compared to untreated dogs and it is also superior to lidocaine treatment at 0.5 h following the visual analogy pain assessment system. In the present study, the observation of lower pain scores...

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“…FM, a nicotinic acid derivative, inhibits COX, which transfers arachidonic acid to prostanoids (Donalisio et al, 2013;Lee & Maxwell, 2014;Milovanović, Vučković, Prostran, Trailović, & Jovanović, 2016;Yilmaz et al, 2014). In China, FM has been used in cattle (Cetin et al, 2014;Cooke, Cappellozza, Guarnieri, & Bohnert, 2013;Currah, Hendrick, & Stookey, 2009;Huber, Arnholdt, Mostl, Gelfert, & Drillich, 2013;Newby et al, 2017), pigs (Whalin, Pairis-Garcia, Proudfoot, Stalder, & Johnson, 2016), horses (Duz, Parkin, Cullander, & Marshall, 2015;Keegan, Messer, Reed, Wilson, & Kramer, 2008), cats, dogs, and sheep (Marini et al, 2016;Paull, Lee, Colditz, Atkinson, & Fisher, 2007) to treat acute inflammation (Yang et al, 2013), musculoskeletal diseases, bellyache, pain, sow endometritis, mastitis, agalactia syndrome, and canine endotoxemia.…”

Section: Introductionmentioning

confidence: 99%

Development of IC-ELISA and immunochromatographic strip assay for the detection of flunixin meglumine in milk

Lü

Jiang

et al. 2017

Food and Agricultural Immunology

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Flunixin meglumine (FM) is a novel nonsteroidal anti-inflammatory drug for animals, which has antipyretic, analgesic, and antiinflammatory effects. The drug, which was originally used to relieve inflammation in horses, musculoskeletal disorders, and pain, has been approved for use in endotoxemia, infectious diseases in swine, etc. A sensitive anti-FM monoclonal antibody 2H4 was prepared and used to develop an indirect competitive enzyme-linked immunosorbent assay and immunochromatographic strip assay for the detection of FM in milk. The complete antigen and coating antigen were conjugated with bovine serum albumin and ovalbumin, respectively. The monoclonal antibody 2H4, with a half inhibition concentration of 0.29 ng/mL, had a limit of detection of 0.432 ng/mL and a linear range of detection of 0.08664-0.97226 ng/ mL. A sensitive and convenient immunochromatographic strip assay was developed with an FM cutoff value of 0.29 ng/mL. The developed methods were suitable for the detection of FM in milk.

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Comparison of flunixin meglumine and meloxicam influence on postoperative and oxidative stress in ovariohysterectomized bitches

Cited by 16 publications

References 38 publications

Tolfenamic acid and meloxicam both provide an adequate degree of postoperative analgesia in dogs undergoing ovariohysterectomy

Tolfenamic acid and meloxicam both provide an adequate degree of postoperative analgesia in dogs undergoing ovariohysterectomy

Evaluation of Intraperitoneal and Incisional Bupivacaine or Levobupivacaine for Postoperative Analgesia in Ovariohysterectomized Dogs

Development of IC-ELISA and immunochromatographic strip assay for the detection of flunixin meglumine in milk

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