Comparison of four recombinant hepatitis B vaccines applied on an accelerated schedule in healthy adults

Hernández-Bernal, Francisco; Aguilar-Betancourt, Arístides; Aljovin, Virginia; Arias, Gloria A. González; Valenzuela, Carmen; Alejo, K.; Hernández, Karina; Oquendo, Orcilia; Figueredo, Niurka; Figueroa, Nelvis; Musacchio, Andrea; Véliz, Gloria; García, Elizeth; Mollineda, Alina D; Juvier, Ana Isabel; Trujillo, Janette; Delahanty, Aurora; Ortega, Diego Ortíz; Cinza, Zurina; González, Verena Lucila Muzio

doi:10.4161/hv.7.10.15989

Cited by 28 publications

(19 citation statements)

References 34 publications

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“…Despite this, these values are quite high as for individuals with altered immunocompetence. On the other hand, HD patients received additional booster doses if necessary, and in our study, only peak anti-HBs concentrations were registered, whereas in the study by Hernandez-Bernal et al, 27 the anti-HBs titers were monitored after a year from completing an accelerated vaccination schedule (20-µg doses at 0, 1, and 2 months).…”

Section: Anti-hbs Antibody Titers In Relation To Other Clinical Variamentioning

confidence: 87%

“…27 These vaccines contain 20-µg doses of anti-HBs, but were produced by different yeast strains. 27 All these results, except for those for Hepavax Gene, 27 are higher than the ones obtained in our study (23.6%). Despite this, these values are quite high as for individuals with altered immunocompetence.…”

Section: Anti-hbs Antibody Titers In Relation To Other Clinical Variamentioning

confidence: 99%

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Titers of antibodies to the surface antigen of hepatitis B virus after vaccination in relation to immunity-related gene variants. A prospective study among hemodialysis patients

Jodłowska-Siewert¹,

Jagodzińśki²,

Grzegorzewska³

2017

Polish Archives of Internal Medicine

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Section: Anti-hbs Antibody Titers In Relation To Other Clinical Variamentioning

confidence: 87%

Section: Anti-hbs Antibody Titers In Relation To Other Clinical Variamentioning

confidence: 99%

Titers of antibodies to the surface antigen of hepatitis B virus after vaccination in relation to immunity-related gene variants. A prospective study among hemodialysis patients

Jodłowska-Siewert¹,

Jagodzińśki²,

Grzegorzewska³

2017

Polish Archives of Internal Medicine

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“…24,31 In the present study, the percentage of good responder in female was higher than male, and the anti-HBs GMTs in female was higher than male. When the respective groups were compared, there was no significant difference.…”

Section: Discussionmentioning

confidence: 70%

The response of hepatitis B vaccination on seronegative adults with different vaccination schedules

Yao

Chen

et al. 2015

Human Vaccines & Immunotherapeutics

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y These authors equally contributed to this work. Keywords: Hepatitis B vaccine, immunization, adults, ChinaThe purpose of this study was to compare the response of hepatitis B vaccination with different vaccination schedules among seronegative adults, and to provide suitable vaccination schedules for floating and fixed population. The study included adults aged 20 to 39 y without prior history of vaccination with hepatitis B vaccine. The serum samples were collected and tested for hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core antibody (anti-HBc) levels. Out of all, 686 adults who were negative for anti-HBs, anti-HBc and HBsAg were vaccinated with 10 ug hepatitis B vaccine at 0, 1 and 3, 6 or 12 month schedules, and their antibody titers were monitored. The rates of completion of the vaccination in floating and fixed population were 90.4% and 94.1% respectively (p D 0.061). The anti-HBs positive rates in adults vaccinated at 0, 1 and 3 ,6 or12 month were 83.9%, 88.2% and 94.2% respectively (P D 0.0003). The corresponding geometric mean titers (GMTs) were 61.19 (95%CI:47.10-81.23) mIU/mL, 214.04(95%CI:157.14-291.61) mIU/mL and 345.78(95%CI:251.25-475.77) mIU/mL, respectively ( P < 0.0001). Vaccination of hepatitis B with both 0-1-6 and 0-1-12 month schedules in adults result in better level of immune responses. Also, a longer vaccination schedule (0-1-12 month) may be more suitable for floating population and 0-1-6 month schedule is recommended for the fixed population.

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“…Recombinant HB vaccines with 3-or 4-dose schedules, such as Engerix-B, are effective and safe for infants 67,68 and adults. [69][70][71] To our knowledge, no large-scale randomized controlled trials (RCTs) have yet assessed the efficacy and safety of HB vaccines in pregnant women, 72 likely due to ethical issues. 8 However, several studies with small numbers of samples have reported the immunity and safety of recombinant HB vaccines [73][74][75][76][77][78][79][80] and Heptavax, 51,61,81 during pregnancy (Tables 1 and 2), and Heptavax has been replaced by the former vaccines since the 1990s.…”

Section: Efficacy and Safety Of Hb Vaccinesmentioning

confidence: 99%

Viral hepatitis vaccination during pregnancy

Zhao

Jin

Zhang

et al. 2016

Human Vaccines & Immunotherapeutics

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Viral hepatitis is a serious global public health problem. It is also a common cause of jaundice and gestational complications in pregnant women. Moreover, infected mothers can transmit the virus to their fetus or neonate, which may increase disease burden and decrease quality of life. To date, commercial vaccines have been developed for hepatitis A, B, and E and are available to the general population. The Advisory Committee on Immunization Practices currently accepts emergency vaccination against hepatitis A and B during pregnancy due to benefits that overweight the potential risks. While there are limited data from trials with limited numbers of samples that suggest the efficacy or safety of hepatitis B and E vaccines in pregnant women, additional data are necessary to provide evidence of vaccination during pregnancy.

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Comparison of four recombinant hepatitis B vaccines applied on an accelerated schedule in healthy adults

Cited by 28 publications

References 34 publications

Titers of antibodies to the surface antigen of hepatitis B virus after vaccination in relation to immunity-related gene variants. A prospective study among hemodialysis patients

Titers of antibodies to the surface antigen of hepatitis B virus after vaccination in relation to immunity-related gene variants. A prospective study among hemodialysis patients

The response of hepatitis B vaccination on seronegative adults with different vaccination schedules

Viral hepatitis vaccination during pregnancy

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