Comparison of Fractional Flow Reserve with Resting Non-Hyperemic Indices in Patients with Coronary Artery Disease

Zdzierak, Barbara; Zasada, Wojciech; Krawczyk‐Ożóg, Agata; Rakowski, Tomasz; Bartuś, Stanisław; Surdacki, Andrzej; Dziewierz, Artur

doi:10.3390/jcdd10020034

Cited by 2 publications

(3 citation statements)

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“…In previous research, we found discrepancies between FFR and iFR/RFR in 19.2% of assessed angiographically intermediate stenoses [19]. The present analysis revealed that sex was not associated with increased risk of discordant results.…”

Section: Discussionsupporting

confidence: 50%

“…The main results of our study have been previously published [19]. Data were retrospectively collected for all consecutive patients hospitalized at the Clinical Department of Cardiology and Cardiovascular Interventions of the University Hospital in Kraków between January 2020 and December 2021, in whom invasive physiological assessment of the angiographically intermediate coronary lesions was performed, regardless of the method used.…”

Section: Methodsmentioning

confidence: 99%

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Influence of sex on the functional assessment of myocardial ischemia

et al. 2023

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Background: Fractional flow reserve (FFR) and non-hyperemic resting pressure ratios, such as instantaneous wave-free ratio (iFR) and resting full-cycle ratio (RFR), are recommended for evaluating the significance of angiographically intermediate coronary stenoses. Despite their usefulness, approximately 20% of assessed lesions exhibit discordance between FFR and iFR/RFR. Aims:The role of sex in this discrepancy remains uncertain; thus, we aimed to investigate its impact on the discordance between FFR and iFR/RFR. Methods:We reviewed 417 consecutive intermediate stenotic lesions from 381 patients, stratified by sex and assessed with both FFR and iFR/RFR. FFR ≤0.80 and iFR/RFR ≤0.89 were considered positive for ischemia.Results: Of the 381 patients, 92 (24.1%) were women. Women were older, had a lower estimated glomerular filtration rate (eGFR), higher ejection fraction, and were more likely to have peripheral artery disease than men. Median FFR and iFR/RFR values were lower in men than in women (FFR 0.86 vs. 0.80; P <0.001; iFR 0.92 vs. 0.90; P = 0.049). However, overall discordance prevalence was similar for both sexes (20.6% vs. 15.1%; P = 0.22). In men, eGFR, insulin-treated diabetes mellitus, and arterial hypertension were predictors of positive FFR | negative iFR/RFR discordance, while eGFR, insulin-treated diabetes mellitus, atrial fibrillation, and chronic obstructive pulmonary disease were predictors of negative FFR | positive iFR/RFR discordance. No factors associated with either discordance were identified in women.Conclusions: FFR and iFR/RFR results indicating significant ischemia were more common in men than women when assessing intermediate coronary stenoses. Nevertheless, sex did not predict discordant results.

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