Comparison of frequencies of atrial fibrillation after coronary artery bypass grafting with and without the use of cardiopulmonary bypass

J, Abreu; Reilly, John P.; Salzano, Richard; Khachane, Vasant B.; Jekel, James F.; Clyne, Christopher A.

doi:10.1016/s0002-9149(98)00988-6

Cited by 47 publications

(24 citation statements)

References 16 publications

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“…POAF occurred in 16% patients. Those patients with POAF appeared to be older and sicker than those without POAF, a finding consistently seen in other studies (17)(18)(19)(20) and in ours. Although the investigators adjusted for many comorbid conditions when testing the effect of POAF on mortality, they did not account for the effect of race (21,22), ejection fraction (23), the presence of concomitant valve disease (15), dialysis (24), left main coronary artery disease (25), or creatinine level (26,27).…”

Section: Demographic and Pre-operative Risk Factors For Poaf Patientssupporting

confidence: 91%

New-Onset Atrial Fibrillation Predicts Long-Term Mortality After Coronary Artery Bypass Graft

El‐Chami

Kilgo

Thourani

et al. 2010

Journal of the American College of Cardiology

303

192

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Section: Demographic and Pre-operative Risk Factors For Poaf Patientssupporting

confidence: 91%

New-Onset Atrial Fibrillation Predicts Long-Term Mortality After Coronary Artery Bypass Graft

El‐Chami

Kilgo

Thourani

et al. 2010

Journal of the American College of Cardiology

303

192

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“…However, in their study the lower incidence of AF was due to different clinical characteristics of the patients rather than the use of offpump technique per se. Abrey et al [13] also reported a trend towards a lower incidence of AF after off-pump CABG compared to on-pump CABG. However, their study was retrospective and there were only 34 patients in the offpump group.…”

Section: Discussionmentioning

confidence: 92%

Cardioplegic arrest does not increase the risk of atrial fibrillation after coronary artery bypass surgery

Hakala

Pitkänen

Hartikainen

2004

European Journal of Cardio-Thoracic Surgery

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Objective: Atrial fibrillation (AF) is the most common arrhythmia after coronary artery bypass grafting (CABG). It is a considerable source of morbidity, prolongs hospital stay and increases costs of treatment. Atrial cannulation, cardiopulmonary bypass and cardioplegic arrest have been suggested to play a role in the development of AF after CABG. The aim of this case-control study was to evaluate the role of cardiopulmonary bypass and cardioplegic arrest in the development of postoperative AF. Methods: Data from 114 patients undergoing CABG without cardiopulmonary bypass and cardioplegic arrest (off-pump) between October, 1998 and December, 2002 were evaluated for the occurrence of postoperative AF. Each patient was individually matched by gender, age (^3 years), left ventricle ejection fraction (^5%), history of myocardial infarction, unstable angina, and b-blocker medication with patients undergoing CABG with cardiopulmonary bypass and cardioplegic arrest (on-pump) during the same period. The data from off-pump and on-pump groups were compared. Results: Off-pump and on-pump groups had similar preoperative characteristics. The number of distal anastomoses was lower in the off-pump (2.3^0.9) than in the on-pump (3.9^1.1, P , 0:001) group. However, the incidence of postoperative AF in the off-pump (36.8%) and the on-pump groups (36.0%) did not differ from each other. Old age was the only independent predictor of AF after CABG. Conclusions: Neither cardiopulmonary bypass nor cardioplegic arrest increases the risk of postoperative AF after CABG. q

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“…[21][22][23] The observation of a link between postoperative complement activation and atrial arrhythmias in CABG patients 4 and the evidence derived from the analysis of atrial specimens from patients with isolated AF that atrial myocarditis can constitute the histological background of this arrhythmia, 3 led further support to an "inflammatory" theory of the pathophysiology of postoperative AF.…”

Section: Discussionmentioning

confidence: 99%

The −174G/C Interleukin-6 Polymorphism Influences Postoperative Interleukin-6 Levels and Postoperative Atrial Fibrillation. Is Atrial Fibrillation an Inflammatory Complication?

et al. 2003

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Background-It has been suggested that inflammation can have a role in the development of atrial arrhythmias after cardiac surgery and that a genetic predisposition to develop postoperative complications exists. This study was conceived to verify if a potential genetic modulator of the systemic inflammatory reaction to cardiopulmonary bypass (the Ϫ174 G/C polymorphism of the promoter of the Interleukin-6 gene) has a role in the pathogenesis of postoperative atrial fibrillation (AF). Patients and Results-In 110 primary isolated coronary artery bypass patients the Ϫ174G/C Interleukin-6 promoter gene variant was determined. Interleukin-6, fibrinogen and C-reactive protein plasma levels were determined preoperatively, 24, 48, and 72 hours after surgery and at discharge. Heart rate and rhythm were continuously monitored for the first 36 to 48 hours; daily 12-lead electrocardiograms were performed thereafter until discharge. GG, CT, and CC genotypes were found in 62, 38, and 10 patients, respectively. Multivariate analysis (which included genotype, age, sex, and classical risk factors for AF) identified the GG genotype as the only independent predictor of postoperative AF. The latter occurred in 33.9% of GG versus 10.4% of non-GG patients (hazard ratio 3.25, 95%CI 1.23 to 8.62). AF patients had higher blood levels of Interleukin-6 and fibrinogen after surgery (PϽ0.001 for difference between the area under the curve). Conclusion-The

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Comparison of frequencies of atrial fibrillation after coronary artery bypass grafting with and without the use of cardiopulmonary bypass

Cited by 47 publications

References 16 publications

New-Onset Atrial Fibrillation Predicts Long-Term Mortality After Coronary Artery Bypass Graft

New-Onset Atrial Fibrillation Predicts Long-Term Mortality After Coronary Artery Bypass Graft

Cardioplegic arrest does not increase the risk of atrial fibrillation after coronary artery bypass surgery

The −174G/C Interleukin-6 Polymorphism Influences Postoperative Interleukin-6 Levels and Postoperative Atrial Fibrillation. Is Atrial Fibrillation an Inflammatory Complication?

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