Comparison of frontal alpha asymmetry among schizophrenia patients, major depressive disorder patients, and healthy controls

Jang, Kuk-In; Lee, Chany; Lee, Sang‐Min; Huh, Sungmin; Chae, Jeong‐Ho

doi:10.1186/s12888-020-02972-8

Cited by 17 publications

(12 citation statements)

References 61 publications

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“…8,11 In addition to the overall reductions in alpha activity, individuals with schizophrenia typically exhibit a hemispheric asymmetry of more alpha power in the left hemisphere compared to the right. 13,14,15,16 This alpha asymmetry was also found in a sample of individuals with early-phase psychosis. 13 Healthy controls exhibit symmetrical alpha power and this symmetry in the alpha band is thought to be needed for effective information processing.…”

Section: Eeg the Resting State And Caffeinesupporting

confidence: 56%

Alteration of Resting Electroencephalography by Acute Caffeine Consumption in Early Phase Psychosis

et al. 2021

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Individuals with schizophrenia use twice as much caffeine on average when compared to healthy controls. Knowing the high rates of consumption, and the potential negative effects of such, it is important we understand the cortical mechanisms that underlie caffeine use, and the consequences of caffeine use on neural circuits in this population. Using a randomized, placebo controlled, double-blind, repeated measures design, the current study examines caffeine's effects on resting electroencephalography (EEG) power in those who have been recently diagnosed with schizophrenia (SZ) compared to regular-using healthy controls (HC). Correlations between average caffeine consumption, withdrawal symptoms, drug related symptoms and clinical psychosis symptoms were measured and significant correlations with neurophysiological data were examined. Results showed caffeine had no effect on alpha asymmetry in the SZ group, although caffeine produced a more global effect on the reduction of alpha2 power in the SZ group. Further, those with more positive symptoms were found to have a greater reduction in alpha2 power following caffeine administration. Caffeine also reduced beta power during eyes closed and eyes open resting in HC, but only during eyes closed resting conditions in the SZ group. These findings provide a descriptive profile of the resting EEG state following caffeine administration in individuals with schizophrenia. The findings ultimately suggest caffeine does not affect alpha or beta power as readily in this population and a higher dose may be needed to achieve the desired effects, which may elucidate motivational factors for high caffeine use.

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Section: Eeg the Resting State And Caffeinesupporting

confidence: 56%

Alteration of Resting Electroencephalography by Acute Caffeine Consumption in Early Phase Psychosis

et al. 2021

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“…Although the previous findings confirmed the hypothesis that MDD was characterized by right-lateralization, other authors failed to find significant differences between groups or report a reduced or a lack of EEG asymmetry in depressed patients [61], [62]. No significant differences were also found in Jang et al [63] in which depressed patients' frontal alpha asymmetry scores were compared with those of schizophrenic and healthy subjects. EEG alpha asymmetry was also assessed in order to discriminate between healthy subjects and patients with different depressive subtypes.…”

Section: ) Eeg Asymmetrymentioning

confidence: 73%

Discriminative Power of EEG-Based Biomarkers in Major Depressive Disorder: A Systematic Review

et al. 2021

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Currently, the diagnosis of major depressive disorder (MDD) and its subtypes is mainly based on subjective assessments and self-reported measures. However, objective criteria as Electroencephalography (EEG) features would be helpful in detecting depressive states at early stages to prevent the worsening of the symptoms. Scientific community has widely investigated the effectiveness of EEG-based measures to discriminate between depressed and healthy subjects, with the aim to better understand the mechanisms behind the disorder and find biomarkers useful for diagnosis. This work offers a comprehensive review of the extant literature concerning the EEG-based biomarkers for MDD and its subtypes, and identify possible future directions for this line of research. Scopus, PubMed and Web of Science databases were researched following PRISMA's guidelines. The initial papers' screening was based on titles and abstracts; then full texts of the identified articles were examined, and a synthesis of findings was developed using tables and thematic analysis. After screening 1871 articles, 76 studies were identified as relevant and included in the systematic review. Reviewed markers include EEG frequency bands power, EEG asymmetry, ERP components, non-linear and functional connectivity measures. Results were discussed in relations to the different EEG measures assessed in the studies. Findings confirmed the effectiveness of those measures in discriminating between healthy and depressed subjects. However, the review highlights that the causal link between EEG measures and depressive subtypes needs to be further investigated and points out that some methodological issues need to be solved to enhance future research in this field.

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“…It is known that eye closing would alter the amplitude of alpha oscillation and FAA would have high stability representing alpha asymmetry recorded when the patient’s eyes were open [ 6 ]. In this study, hf-tRNS was applied in an eyes-open state.…”

Section: Methodsmentioning

confidence: 99%

“…Research indicates that structural, functional, and metabolic abnormalities are dominant in the mid-frontal region of patients with schizophrenia [ 5 ]. Electroencephalographic (EEG) frontal alpha asymmetry (FAA), particularly in the midfrontal area, has been suggested to be a biomarker for the imbalance of interhemispheric activity of schizophrenia [ 6 , 7 ]. FAA is expressed as the difference between absolute power values of frontal right and left hemisphere electrodes in the alpha frequency range.…”

Section: Introductionmentioning

confidence: 99%

“…Research applying FAA as a tool to examine the motivational direction model of asymmetric frontal brain activity in schizophrenia indicates a reduced left-lateralized FAA in patients compared to controls. This suggests that left-lateralized FAA may underlie diminished approach motivation and represent a neuropathological attribute of these patients [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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High-Frequency Transcranial Random Noise Stimulation over the Left Prefrontal Cortex Increases Resting-State EEG Frontal Alpha Asymmetry in Patients with Schizophrenia

Yeh

Huang

Chung

et al. 2022

JPM

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Reduced left-lateralized electroencephalographic (EEG) frontal alpha asymmetry (FAA), a biomarker for the imbalance of interhemispheric frontal activity and motivational disturbances, represents a neuropathological attribute of negative symptoms of schizophrenia. Unidirectional high-frequency transcranial random noise stimulation (hf-tRNS) can increase the excitability of the cortex beneath the stimulating electrode. Yet, it is unclear if hf-tRNS can modulate electroencephalographic FAA in patients with schizophrenia. We performed a randomized, double-blind, sham-controlled clinical trial to contrast hf-tRNS and sham stimulation for treating negative symptoms in 35 schizophrenia patients. We used electroencephalography to investigate if 10 sessions of hf-tRNS delivered twice-a-day for five consecutive weekdays would modulate electroencephalographic FAA in schizophrenia. EEG data were collected and FAA was expressed as the differences between common-log-transformed absolute power values of frontal right and left hemisphere electrodes in the alpha frequency range (8–12.5 Hz). We found that hf-tRNS significantly increased FAA during the first session of stimulation (p = 0.009) and at the 1-week follow-up (p = 0.004) relative to sham stimulation. However, FAA failed to predict and surrogate the improvement in the severity of negative symptoms with hf-tRNS intervention. Together, our findings suggest that modulating electroencephalographic frontal alpha asymmetry by using unidirectional hf-tRNS may play a key role in reducing negative symptoms in patients with schizophrenia.

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Comparison of frontal alpha asymmetry among schizophrenia patients, major depressive disorder patients, and healthy controls

Cited by 17 publications

References 61 publications

Alteration of Resting Electroencephalography by Acute Caffeine Consumption in Early Phase Psychosis

Alteration of Resting Electroencephalography by Acute Caffeine Consumption in Early Phase Psychosis

Discriminative Power of EEG-Based Biomarkers in Major Depressive Disorder: A Systematic Review

High-Frequency Transcranial Random Noise Stimulation over the Left Prefrontal Cortex Increases Resting-State EEG Frontal Alpha Asymmetry in Patients with Schizophrenia

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