Comparison of Frozen Section and Touch Imprint Cytology for Evaluation of Sentinel Lymph Node Metastasis in Breast Cancer

Aihara, Tomohiko; Munakata, Satoru; Morino, Hideo; Takatsuka, Yuichi

doi:10.1245/aso.2004.01.014

Cited by 51 publications

(29 citation statements)

References 12 publications

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“…Touch imprint cytology (TIC), frozen section (FS) analysis and onestep nucleic-acid amplification (OSNA) represent the most common techniques available to intraoperatively detect breast cancer axillary sentinel lymph node (SLN) metastasis [8,9]. However, recent studies have stated that TIC is not anymore, a useful technique to detect SLN metastasis in breast cancer [17,18].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Sentinel Lymph Node Intraoperative Touch Imprint Cytology in Breast Cancer Surgery

Iacuzzo¹,

Troian²,

Bonadio³

et al. 2017

J Mol Biomark Diagn

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Background: One of the strongest prognostic factor for breast cancer is the regional lymph node status, which can be evaluated intraoperatively by sentinel lymph node biopsy. Many methods (e.g. frozen section, touch imprint cytology (TIC) and one-step nucleic-acid amplification) are available to detect metastatic cells in axillary lymph nodes. The aim of this study is to evaluate the feasibility of using TIC to detect metastatic cells in sentinel lymph nodes.

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Section: Discussionmentioning

confidence: 99%

“…The most common ones include frozen section (FS), touch imprint cytology (TIC) [8] and one-step nucleicacid amplification (OSNA) [9].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Sentinel Lymph Node Intraoperative Touch Imprint Cytology in Breast Cancer Surgery

Iacuzzo¹,

Troian²,

Bonadio³

et al. 2017

J Mol Biomark Diagn

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show abstract

“…Thus, one might argue that our nomograms are not applicable for institutions, where frozen section is used instead of TIC. However, studies directly comparing frozen section with TIC showed that sensitivities of both methods are comparable [20,21]. Furthermore, Lambert LA et al who validated MSKCC nomogram (which uses frozen section), showed that TIC seems to be an acceptable substitute for frozen section as a nomogram variable [22].…”

Section: Discussionmentioning

confidence: 99%

Ljubljana nomograms for predicting the likelihood of non-sentinel lymph node metastases in breast cancer patients with a positive sentinel lymph node

Perhavec

Perme

Hočevar

et al. 2009

Breast Cancer Res Treat

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“…And, last, which is the most limiting step in clinical practice, neither imprint cytology nor frozen sections yield satisfactory results as they do for breast cancer and melanoma [5,11,12]. In breast cancer and melanoma, many centers report that intraoperative diagnosis with these methods shows high sensitivity and high specificity, both being higher than 90% for each method [6,13].…”

Section: Discussionmentioning

confidence: 99%

The value of intraoperative imprint cytology in the assessment of lymph node status in gastric cancer surgery

et al. 2005

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gastrectomy with safe margins and routine lymphadenectomy, mostly more than D2 according to the Japanese classification [1]. So the evaluation of lymph node status was only possible in the late postoperative period through the histologic examination of formalinfixed surgical specimens, which means that surgeons had to perform lymphadenectomy without an exact knowledge of the lymph node status.From the development of the sentinel node concept in melanoma and breast cancer, numerous techniques have evolved to assess lymph node status intraoperatively, such as frozen section, imprint cytology, rapid immunostaining, and other molecular methods. Through these techniques, surgeons have been able to avoid unnecessary lymph node dissection with an acceptable risk of an additional trip to the operation room.As more patients are now being diagnosed in the early stages of gastric cancer, many attempts are being made to reduce both the extent of lymph node dissection and the extent of gastric resection itself. Even though many studies have proposed risk factors which predict the likelihood of lymph node metastasis in gastric cancer, no single risk factor can perfectly predict lymph node metastasis preoperatively. So performing limited surgery in gastric cancer patients without exact knowledge of lymph node status always carries a risk of residual nodal disease. Because reoperation to complete lymph node dissection carries the risk of additional morbidities, the need for accurate intraoperative diagnosis of lymph node metastasis is greater than ever.Here, we report the result of our study of the accuracy and usefulness of imprint cytology as a tool to assess lymph node status intraoperatively in gastric cancer surgery. AbstractBackground. The intraoperative assessment of lymph node status is important when performing limited surgery in gastric cancer patients. Currently available techniques for this assessment are frozen section, imprint cytology, and other molecular methods; most current studies use the frozen-section method. In the present study, we focused on the accuracy and feasibility of imprint cytology as a tool to assess lymph node status intraoperatively in gastric cancer surgery. Methods. Between April 2001 and March 2003, we performed imprint cytology of the sentinel nodes in 260 consecutive patients. After review by an experienced cytopathologist, the sensitivity, specificity, and overall accuracy of the method were determined. Results. The time required for the intraoperative imprint cytology was 8 min, and the sensitivity, specificity, and overall accuracy were 52.2%, 88.8%, and 73.8%, respectively. Conclusion. Imprint cytology could be a useful technique for the assessment of lymph node status intraoperatively if the sensitivity and specificity can be improved to an acceptable level.

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Comparison of Frozen Section and Touch Imprint Cytology for Evaluation of Sentinel Lymph Node Metastasis in Breast Cancer

Abstract: The sensitivity of FS was almost equivalent to that of TIC. TIHC had a better sensitivity than FS and TIC, but it upstaged a few node-negative patients.

Cited by 51 publications

References 12 publications

Evaluation of Sentinel Lymph Node Intraoperative Touch Imprint Cytology in Breast Cancer Surgery

Evaluation of Sentinel Lymph Node Intraoperative Touch Imprint Cytology in Breast Cancer Surgery

Ljubljana nomograms for predicting the likelihood of non-sentinel lymph node metastases in breast cancer patients with a positive sentinel lymph node

The value of intraoperative imprint cytology in the assessment of lymph node status in gastric cancer surgery

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