Comparison of functional-oil blend and anticoccidial antibiotics effects on performance and microbiota of broiler chickens challenged by coccidiosis

Pires, Paula Gabriela da Silva; Torres, Pedro; Soratto, Tatiany Aparecida Teixeira; Filho, Vilmar Benetti; Hauptli, Lucélia; Wagner, Glauber; Haese, Douglas; Pozzatti, Carolina D'ávila; Moraes, Priscila de Oliveira

doi:10.1371/journal.pone.0270350

Cited by 6 publications

(2 citation statements)

References 48 publications

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“…Analysis of previously published data gives a number of indirect clues confirming the efficiency of grass biomass as a source of beneficial bacteria (analogs of probiotics). Probiotics, like antibiotics (e.g., enramycin and tylosin), confer resistance against Eimeria on the chicken, although they do not exhibit antagonism towards Apikomplexa sporozoits in vitro [27]. Moreover, the concept of the necessity of long-term persistence of the probiotics in GIT was revised.…”

Section: Discussionmentioning

confidence: 99%

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Grass Meal Acts as a Probiotic in Chicken

Bogdanova,

Danilova,

Smirnova

et al. 2023

Microbiology Research

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Probiotics can act as an alternative to antibiotics in animal feeding, but their use is minimal due to their expensive production. Dry grass is rich with bacteria beneficial for animal feeding and can be used as a probiotic. However, data about the quantitative dependence of the grass microbiome on environmental factors and seasons remain insufficient for preparing “grass-meal-based probiotics”. Four grass samples were collected in two geographically remote regions of Russia; their microbiome was characterized by metagenomic sequencing of 16S rDNA libraries and microbiological seeding, and biological testing of the grass meal was carried out on 6 groups of birds containing 20 Ross 308 cross broilers each for a period of 42 days. The positive control group (PC) obtained 16–25 mg/mL toltrazuril (coccidiostatic agent) and 0.5 mL/L liquid antibiotic enrostin (100 mg/mL ciprofloxacin and 106 MU/mL colistin sulfate in the commercial preparation) within the drinking water, while the negative control group (NC) obtained no medicines. Four experimental groups were fed the diet supplemented with 1% grass meal over the period of 7–42 days of life; no commercial medicines were used here. A spontaneous infection with Eimeria was registered in the NC control groups, which caused the loss of 7 chickens. No losses were registered in the PC group or the two experimental groups. In two other experimental groups, losses of coccidiosis amounted to 10% and 15%, respectively. All specimens of the grass meal demonstrated a significant effect on the average body weight gain compared to NC. Taken together, these observations support the hypothesis that the grass meal may substitute toltrazuril for protecting the chickens from parasitic invasion and increase average daily weight gain (ADG) as effectively as the antibiotic enrostin.

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Section: Discussionmentioning

confidence: 99%

“…Significantly, probiotics, like antibiotics (e.g., enramycin and tylosin), confer resistance against Eimeria on the chicken, although they do not exhibit antagonism towards Apikomplexa sporozoits in vitro [27]. Moreover, the concept of the necessity of long-term persistence of the probiotics in GIT was revised.…”

Section: Introductionmentioning

confidence: 99%

Grass Meal Acts as a Probiotic in Chicken

Bogdanova,

Danilova,

Smirnova

et al. 2023

Microbiology Research

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Plants, plant‐derived compounds, probiotics, and postbiotics as green agents to fight against poultry coccidiosis: A review

Chen,

Liu,

Yue

et al. 2024

Animal Research and One Health

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The intestinal tract is the main place for animals to digest food and absorb nutrients, which also serves as the first line of defense against pathogens that invade the internal environment. Therefore, normal intestinal structure and function are essential for animal health. Poultry coccidiosis is an intestinal disease primarily caused by the parasitization of intestinal epithelial cells by protozoa of the genus Eimeria. The occurrence of coccidiosis not only compromises the intestinal integrity of poultry but also increases their disease susceptibility, thus posing a serious threat to the overall health and productivity of poultry. Nowadays, the primary methods for controlling and preventing coccidiosis in poultry are anticoccidial drugs or live oocyst vaccines. However, the use of the former may be associated with problems of resistance and drug residues, while the use of the latter may cause intestinal damage and significantly increase farming costs. For these reasons, it is critical to investigate green, safe, and cost‐effective natural alternative strategies such as phytochemicals and probiotics for controlling coccidiosis as well as mitigating the deleterious effects of coccidial infections in production. In this review, we aim to summarize the role, mechanisms, and therapeutic potential of natural products in the treatment of coccidiosis to lay a theoretical foundation for effective coccidiosis control.

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