Comparison of functional residual capacity between updated infant SF<sub>6</sub> multiple‐breath washout setups

Oestreich, Marc‐Alexander; Hänni, Robin; Wyler, Florian; Kentgens, Anne‐Christianne; Yammine, Sophie; Obrist, Dominik; Latzin, Philipp; Ramsey, Kathryn A.

doi:10.1002/ppul.26770

Pediatric Pulmonology

2023

DOI: 10.1002/ppul.26770

|View full text |Cite

Comparison of functional residual capacity between updated infant SF₆ multiple‐breath washout setups

Marc‐Alexander Oestreich,

Robin Hänni,

Florian Wyler

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Optimized algorithm for speed‐of‐sound‐based infant sulfur hexafluoride multiple‐breath washout measurements

Wyler,

Manogaran,

Monney

et al. 2024

Pediatric Pulmonology

View full text Add to dashboard Cite

IntroductionMajor methodological issues with the existing algorithm (WBreath) used for the analysis of speed‐of‐sound‐based infant sulfur hexafluoride (SF6) multiple‐breath washout (MBW) measurements lead to implausible results and complicate the comparison between different age groups and centers.MethodsWe developed OASIS—a novel algorithm to analyze speed‐of‐sound‐based infant SF6 MBW measurements. This algorithm uses known context of the measurements to replace the dependence of WBreath on model input parameters. We validated the functional residual capacity (FRC) measurement accuracy of this new algorithm in vitro, and investigated its use in existing infant MBW data sets from different infant cohorts from Switzerland and South Africa.ResultsIn vitro, OASIS managed to outperform WBreath at FRC measurement accuracy, lowering mean (SD) absolute error from 5.1 (3.2) % to 2.1 (1.6) % across volumes relevant for the infant age range, in variable temperature, respiratory rate, tidal volume and ventilation inhomogeneity conditions. We showed that changes in the input parameters to WBreath had a major impact on MBW results, a methodological drawback which does not exist in the new algorithm. OASIS produced more plausible results than WBreath in longitudinal tracking of lung clearance index (LCI), provided improved measurement stability in LCI over time, and improved comparability between centers.DiscussionThis new algorithm represents a meaningful advance in obtaining results from a legacy system of lung function measurement by allowing a single method to analyze measurements from different age groups and centers.

show abstract

Optimized algorithm for speed‐of‐sound‐based infant sulfur hexafluoride multiple‐breath washout measurements

Wyler,

Manogaran,

Monney

et al. 2024

Pediatric Pulmonology

View full text Add to dashboard Cite

show abstract

Sulfur hexafluoride multiple breath washin and washout outcomes in infants are not interchangeable

Kentgens,

Wyler,

Oestreich

et al. 2024

Physiol. Meas.

View full text Add to dashboard Cite

Objective. Sulfur hexafluoride (SF6) multiple-breath washout (MBW) assesses ventilation inhomogeneity, as an early marker of obstructive respiratory diseases. Primary outcomes are customarily washout-derived, and it is unclear whether the preceding SF6-washin can provide similar estimates. We aimed to assess comparability of primary SF6-MBW outcomes between washin and washout phases of infant SF6-MBW data measured with the WBreath (ndd Medizintechnik AG, Zurich, Switzerland) and Spiroware (Eco Medics AG, Duernten, Switzerland) MBW-setups, respectively. Approach. We assessed mean relative differences in lung clearance index (LCI) and functional residual capacity (FRC) between the washin and washout of existing SF6-MBW data from healthy infants and infants with cystic fibrosis (CF). We assessed whether these differences exceeded the mean relative within-test between-trial differences of washout-derived outcomes, which can be attributed to natural variability. We also explored non-physiological factors using a pediatric lung simulator. Main results. LCI and FRC from washin and washout were not comparable, for both setups. The mean difference (SD) in LCI between washin and washout was 2.3(10.8)% for WBreath and -9.7(8.0)% for Spiroware, while in FRC it was -4.7(7.8)% for WBreath and -2.3(9.7)% for Spiroware. These differences exceeded the within-test between-trial differences in washout-derived outcomes. Outcomes from washin and washout were also not comparable in a pediatric lung simulator.Significance. Outcomes of the washin and washout were not comparable due to an interplay of physiological and non-physiological factors, and cannot be used interchangeably.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Comparison of functional residual capacity between updated infant SF₆ multiple‐breath washout setups

Cited by 2 publications

References 6 publications

Optimized algorithm for speed‐of‐sound‐based infant sulfur hexafluoride multiple‐breath washout measurements

Optimized algorithm for speed‐of‐sound‐based infant sulfur hexafluoride multiple‐breath washout measurements

Sulfur hexafluoride multiple breath washin and washout outcomes in infants are not interchangeable

Contact Info

Product

Resources

About

Comparison of functional residual capacity between updated infant SF6 multiple‐breath washout setups

Cited by 2 publications

References 6 publications

Optimized algorithm for speed‐of‐sound‐based infant sulfur hexafluoride multiple‐breath washout measurements

Optimized algorithm for speed‐of‐sound‐based infant sulfur hexafluoride multiple‐breath washout measurements

Sulfur hexafluoride multiple breath washin and washout outcomes in infants are not interchangeable

Contact Info

Product

Resources

About

Comparison of functional residual capacity between updated infant SF₆ multiple‐breath washout setups