Comparison of gadolinium nanoparticles and molecular contrast agents for radiation therapy‐enhancement

Delorme, Rachel; Taupin, Florence; Flaender, Mélanie; Ravanat, Jean‐Luc; Champion, C.; Agelou, M.; Elleaume, Hélène

doi:10.1002/mp.12570

Cited by 38 publications

(31 citation statements)

References 40 publications

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“…Regarding the study of GBNPs, most of them have been used as MRI contrast agents [32–34]. Recently, there have been efforts to study the radiosensitizing properties of GBNPs, opening the door for GBNPs to be used as potential theranostic agents [35, 36], while the biological radiosensitizing mechanisms of GONs under carbon ion irradiation still need further study.…”

Section: Discussionmentioning

confidence: 99%

Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation

Jin

et al. 2019

Nanoscale Res Lett

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Gadolinium-based nanomaterials can not only serve as contrast agents but also contribute to sensitization in the radiotherapy of cancers. Among radiotherapies, carbon ion irradiation is considered one of the superior approaches with unique physical and biological advantages. However, only a few metallic nanoparticles have been used to improve carbon ion irradiation. In this study, gadolinium oxide nanocrystals (GONs) were synthesized using a polyol method to decipher the radiosensitizing mechanisms in non-small cell lung cancer (NSCLC) cell lines irradiated by carbon ions. The sensitizer enhancement ratio at the 10% survival level was correlated with the concentration of Gd in NSCLC cells. GONs elicited an increase in hydroxyl radical production in a concentration-dependent manner, and the yield of reactive oxygen species increased obviously in irradiated cells, which led to DNA damage and cell cycle arrest. Apoptosis and cytostatic autophagy were also significantly induced by GONs under carbon ion irradiation. The GONs may serve as an effective theranostic material in carbon ion radiotherapy for NSCLC.Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation

Jin

et al. 2019

Nanoscale Res Lett

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“…As demonstrated by Monte Carlo simulations, nanoparticles efficiently absorb X-rays and locally enhance the dose delivered in their close surroundings. [29,44,45] A seminal study by Hainfeld et al reported the prolonged control of subcutaneous tumors by intravenously injecting mice with gold nanoparticles, followed by 250 kVp radiation therapy. [46] Many subsequent studies demonstrated physical, chemical, or biological effects of high-Z nanoparticles upon X-ray irradiations.…”

Section: Introductionmentioning

confidence: 99%

Radiation Dose‐Enhancement Is a Potent Radiotherapeutic Effect of Rare‐Earth Composite Nanoscintillators in Preclinical Models of Glioblastoma

et al. 2020

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To improve the prognosis of glioblastoma, innovative radiotherapy regimens are required to augment the effect of tolerable radiation doses while sparing surrounding tissues. In this context, nanoscintillators are emerging radiotherapeutics that down-convert X-rays into photons with energies ranging from UV to near-infrared. During radiotherapy, these scintillating properties amplify radiation-induced damage by UV-C emission or photodynamic effects. Additionally, nanoscintillators that contain high-Z elements are likely to induce another, currently unexplored effect: radiation dose-enhancement. This phenomenon stems from a higher photoelectric absorption of orthovoltage X-rays by high-Z elements compared to tissues, resulting in increased production of tissue-damaging photo-and Auger electrons. In this study, Geant4 simulations reveal that rare-earth composite LaF 3 :Ce nanoscintillators effectively generate photo-and Auger-electrons upon orthovoltage X-rays. 3D spatially resolved X-ray fluorescence microtomography shows that LaF 3 :Ce highly concentrates in microtumors and enhances radiotherapy in an X-ray energy-dependent manner. In an aggressive syngeneic model of orthotopic glioblastoma, intracerebral injection of LaF 3 :Ce is well tolerated and achieves complete tumor remission in 15% of the subjects receiving monochromatic synchrotron radiotherapy. This study provides unequivocal evidence for radiation dose-enhancement by nanoscintillators, eliciting a prominent radiotherapeutic effect. Altogether, nanoscintillators have invaluable properties for enhancing the focal damage of radiotherapy in glioblastoma and other radioresistant cancers.

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“…Gd is a lanthanide element with powerful high energy ionization radiation absorption ability and the Gd‐based nanomaterials are widely developed as radiosensitizers in recent years . As a paradigm, Le Duc et al used ultrasmall Gd‐based nanoparticles (GBNs) to carry microbeam RT.…”

Section: General Strategies Of Nanomaterial‐mediated Tumor Radiosensimentioning

confidence: 99%

Emerging Strategies of Nanomaterial‐Mediated Tumor Radiosensitization

et al. 2018

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Nano-radiosensitization has been a hot concept for the past ten years, and the nanomaterial-mediated tumor radiosensitization method is mainly focused on increasing intracellular radiation deposition by high atomic number (high Z) nanomaterials, particularly gold (Au)-mediated radiation enhancement. Recently, various new nanomaterial-mediated radiosensitive approaches have been successively reported, such as catalyzing reactive oxygen species (ROS) generation, consuming intracellular reduced glutathione (GSH), overcoming tumor hypoxia, and various synergistic radiotherapy ways. These strategies may open a new avenue for enhancing the radiotherapeutic effect and avoiding its side effects. Nevertheless, reviews systematically summarizing these newly emerging methods and their radiosensitive mechanisms are still rare. Therefore, the general strategies of nanomaterial-mediated tumor radiosensitization are comprehensively summarized, particularly aiming at introducing the emerging radiosensitive methods. The strategies are divided into three general parts. First, methods on account of the intrinsic radiosensitive properties of nanoradiosensitizers for radiosensitization are highlighted. Then, newly developed synergistic strategies based on multifunctional nanomaterials for enhancing radiotherapy efficacy are emphasized. Third, nanomaterial-mediated radioprotection approaches for increasing the radiotherapeutic ratio are discussed. Importantly, the clinical translation of nanomaterial-mediated tumor radiosensitization is also covered. Finally, further challenges and outlooks in this field are discussed.

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Comparison of gadolinium nanoparticles and molecular contrast agents for radiation therapy‐enhancement

Cited by 38 publications

References 40 publications

Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation

Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation

Radiation Dose‐Enhancement Is a Potent Radiotherapeutic Effect of Rare‐Earth Composite Nanoscintillators in Preclinical Models of Glioblastoma

Emerging Strategies of Nanomaterial‐Mediated Tumor Radiosensitization

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