Comparison of Gamma Radiation Crosslinking and Chemical Crosslinking on Properties of Methylcellulose Hydrogel

Abstract

Abstract. In this research, characteristics of methylcellulose (MC) films modified with two crosslinking methods are investigated. The first method is the use of a glutaraldehyde (GA) crosslinker to promote hemi-acetal linkages between MC chains. The second one is gamma irradiation to form insoluble MC gel by intermolecular crosslinking. The effects of the MC concentration on the degree of crosslinking, water absorption, gel content, degree of swelling, and thermomechanical properties were determined. The results indicate that the chemically crosslinked MC films show lower polarity than the radiation crosslinked films. The nature of the crosslinkings was also revealed with FTIR spectra. The waterswelled films of chemically crosslinked MC were found to provide homogeneous gel structure whereas the radiation crosslinked MC films were observed to render less uniform crosslinked films.

Effects of Methylcellulose on the Properties and Morphology of Polysulfone Membranes Prepared by Phase Inversion

“…These results were consistent with those reported in the literature. 39,40 All peaks infrared absorption characteristics of PSf are present in FTIR spectra of PSf/MC membranes (Figure 7a,7c). In addition to the PSf absorption peaks, new peaks were observed in the region of 3200-3500 cm -1 characteristic to the hydroxyl groups (O-H) due probably to the presence of MC in the membranes matrix (Figure 7b).…”

Synthesis and Characterization of Biodegradable Hydrogels for Oral Delivery of 5‐Fluorouracil Targeted to Colon: Screening with Preliminary In Vivo Studies

“…Chemically, cross-linked matrices show high and uniform swelling than radiationinduced cross-linking. 30 EGDMA showed excellent cross-linking between pectin and MAA. Based on physical characterization and drug-release kinetics, the newly developed hydrogel system appeared effective for targeted oral delivery of 5-FU.…”

Dielectric behaviour of UV-crosslinked sulfonated poly (ether ether ketone) with methyl cellulose (SPEEK-MC) as proton exchange membrane

“…To improve our result from the previous study [3], Cellulose Acetate (CA) is replaced with Methyl Cellulose (MC) as CA could not withstand temperature above 50 C. Methyl Cellulose is a biodegradable, non-expensive and nontoxic polymer. It is a modified type of cellulose with a tendency to form crosslinked three-dimensional network hydrogels that tend to swell in water or biological fluids [10]. This paper investigates the influence of the MC compositions on the PEM electrical.…”