Comparison of Ganglion Cell Layer and Ganglion Cell/Inner Plexiform Layer Measures for Detection of Early Glaucoma

Nezhad, Golnoush Sadat Mahmoudi; Mohammadzadeh, Vahid; Martinyan, Jack; Edalati, Kiumars; Zhou, Bingnan; Yaldazadeh, Dariush; Mirzaei, Maryam; Amini, Navid; Nouri‐Mahdavi, Kouros

doi:10.1016/j.ogla.2022.06.008

Cited by 9 publications

(5 citation statements)

References 41 publications

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“…Using the Spectralis software, the GCL thickness could be directly exported without processing. It has been previously shown that GCL thickness was equivalent to ganglion cell complex thickness in glaucoma diagnostic accuracy, 48 and a study using machine learning also showed that GCL thickness measurement was the most important predictor for early glaucoma detection. 49 Third, early and advanced VF damage was defined based on C 24-2 VF results, whereas the present study was mainly based on 10-2 test results.…”

Section: Discussionmentioning

confidence: 93%

Relationships of Macular Functional Impairment With Structural and Vascular Changes According to Glaucoma Severity

Hwang,

Lee,

Kim

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Purpose To determine the pointwise relationships of central visual field (VF) defects with macular ganglion cell loss and macular vessel density (VD) loss during various stages of glaucoma. Methods Eyes with primary open-angle glaucoma (POAG) were subjected to optical coherence tomography (OCT) and OCT angiography (OCTA) to evaluate macular ganglion cell layer (GCL) thickness and macular VD in the superficial and deep vascular complexes (SVC and DVC). OCT, OCTA, and VF locations were matched after correcting for retinal ganglion cell (RGC) displacement. Pointwise correlations of GCL thickness and VDs of the SVC and DVC with central VF sensitivity (VFS) were evaluated by Pearson's correlation analysis and compared in eyes with early and advanced POAG by Meng's test. Results Of the 100 eyes, 52 and 48 were classified as early and advanced POAG. Macular VD showed overall better correlation with central VFS than GCL thickness in both the early and advanced groups. SVC density showed the strongest correlation with central VFS in all groups ( R = 0.327 in early group, R = 0.325 in advanced group, all P < 0.001). Although DVC density showed better correlation with VFS ( R = 0.311) than GCL thickness ( R = 0.212) in the early group ( P < 0.001), the correlation was comparable in the advanced group ( R = 0.199 and 0.176, respectively, P = 0.254). Conclusions After adjustment for RGC displacement, macular SVC density was better correlated with central VFS than macular GCL thickness in both early and advanced POAG. Macular DVC density showed better correlation with VFS than GCL thickness in early but not in advanced POAG, indicating that DVC loss may be involved in early central VF loss.

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Section: Discussionmentioning

confidence: 93%

Relationships of Macular Functional Impairment With Structural and Vascular Changes According to Glaucoma Severity

Hwang,

Lee,

Kim

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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“…In summary, our studies showed that vis-OCT enables the assessment of individual retinal layer structure with high axial resolution and improved contrast. Studies in human patients and animal models have demonstrated the utility of measuring the RNFL, GCL, and IPL thickness in vivo for glaucoma detection ( Fujihara et al, 2020 ; Ghassabi et al, 2022 ; Mahmoudinezhad et al, 2023 ), and this is especially important because changes in the dendritic and axonal structure of RGCs may precede cell death ( Puyang et al, 2015 ; Della Santina and Ou, 2017 ; Feng et al, 2017 ; Grannonico et al, 2023 ). The mechanisms underlying the RGC damage at the soma, dendritic, and axon levels remain controversial.…”

Section: Discussionmentioning

confidence: 99%

Comparative In Vivo Imaging of Retinal Structures in Tree Shrews, Humans, and Mice

Grannonico,

Miller,

Liu

et al. 2024

eNeuro

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Rodent models, such as mice and rats, are commonly used to examine retinal ganglion cell damage in eye diseases. However, as nocturnal animals, rodent retinal structures differ from primates, imposing significant limitations in studying retinal pathology. Tree shrews (Tupaia belangeri) are small, diurnal paraprimates that exhibit superior visual acuity and color vision compared with mice. Like humans, tree shrews have a dense retinal nerve fiber layer (RNFL) and a thick ganglion cell layer (GCL), making them a valuable model for investigating optic neuropathies. In this study, we applied high-resolution visible-light optical coherence tomography to characterize the tree shrew retinal structure in vivo and compare it with that of humans and mice. We quantitatively characterize the tree shrew's retinal layer structure in vivo, specifically examining the sublayer structures within the inner plexiform layer (IPL) for the first time. Next, we conducted a comparative analysis of retinal layer structures among tree shrews, mice, and humans. We then validated our in vivo findings in the tree shrew inner retina using ex vivo confocal microscopy. The in vivo and ex vivo analyses of the shrew retina build the foundation for future work to accurately track and quantify the retinal structural changes in the IPL, GCL, and RNFL during the development and progression of human optic diseases.

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“…The authors investigated the relation between optic disc size determined by CSLT and axial length on RNFL and ganglion cell–inner plexiform layer (GCIPL) in healthy individuals. While GCIPL and GCL are not entirely equivalent, both encompass similar retinal structures and can be considered equivalent with regard to their significance in clinical diagnostics [ 23 ]. While Seo et al did not observe a significant correlation between GCIPL thickness and optic disc size, they report a positive correlation between optic disc size and RNFL thickness [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Retinal Nerve Fiber Layer and Macular Ganglion Cell Layer Thickness in Relation to Optic Disc Size

Storp¹,

Storp²,

Danzer³

et al. 2023

JCM

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To investigate whether optic nerve ganglion cell amount is dependent on optic disc size, this trial analyzes the correlation between Bruch’s membrane opening area (BMOA) and retinal nerve fiber layer (RNFL) thickness as well as macular ganglion cell layer thickness (mGCLT). Additionally, differences in RNFL and mGCLT regarding various optic disc cohorts are evaluated. This retrospective, monocentric study included 501 healthy eyes of 287 patients from the University Hospital Münster, Germany, who received macular and optic disc optical coherence tomography (OCT) scans. Rank correlation coefficients for clustered data were calculated to investigate the relationship between BMOA and thickness values of respective retinal layers. Furthermore, these values were compared between different optic disc groups based on BMOA. Statistical analysis did not reveal a significant correlation between BMOA and RNFL thickness, nor between BMOA and mGCLT. However, groupwise analysis showed global RNFL to be significantly decreased in small and large discs in comparison to medium discs. This was not observed for global mGCLT. This study extends existing normative data for mGCLT taking optic disc size into account. While the ganglion cell amount represented by the RNFL and mGCLT seemed independent of BMOA, mGCLT was superior to global RNFL in displaying optic nerve integrity in very small and very large optic discs.

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Comparison of Ganglion Cell Layer and Ganglion Cell/Inner Plexiform Layer Measures for Detection of Early Glaucoma

Cited by 9 publications

References 41 publications

Relationships of Macular Functional Impairment With Structural and Vascular Changes According to Glaucoma Severity

Relationships of Macular Functional Impairment With Structural and Vascular Changes According to Glaucoma Severity

Comparative In Vivo Imaging of Retinal Structures in Tree Shrews, Humans, and Mice

Evaluation of Retinal Nerve Fiber Layer and Macular Ganglion Cell Layer Thickness in Relation to Optic Disc Size

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