Comparison of gated N-13 ammonia PET and gated Tc-99m sestamibi SPECT for quantitative analysis of global and regional left ventricular function

Abstract

Gated N-13 NH(3) PET combined with QGS provides information on both global and regional left ventricular function comparable to that obtained by gated Tc-99m perfusion myocardial SPECT in CAD patients.

The impacts of severe perfusion defects, akinetic/dyskinetic segments, and viable myocardium on the accuracy of volumes and LVEF measured by gated 99mTc-MIBI SPECT and gated 18F-FDG PET in patients with left ventricular aneurysm: cardiac magnetic resonance imaging as the reference

“…However, no previous study systemically compared the accuracy of LV volumes and LVEF measured by GSPECT and GPET, and little information has become available on the differences of LV volumes and LVEF between GSPECT and GPET. 22,23 In our current study, we found that the correlations of LV volumes measurements between GSPECT and GPET were excellent and correlation of LVEF was fair, but the Bland-Altman limits were wider. Therefore, on individual patient's level, GSPECT and GPET-derived functional parameters (especially LV volumes) should not be interchangeable.…”

“…These findings were different from that in previous studies. 22,23 Kanayama et al 23 found that LVEF did not differ between gated 13 N-NH 3 PET and 99m Tc-MIBI SPECT in CAD patients, and the extent of perfusion defects had no influence on the underestimation of LV volumes determined by GPET, compared with that measured by GSPECT.…”

“…However, no previous study thoroughly compared the accuracy of LV volumes and LVEF measured by GSPECT and GPET, and little information has become available whether GSPECT and GPET-derived functional parameters are interchangeable. 22,23 Therefore, we aimed to compare the accuracy of LV end-diastolic and end-systolic volumes (EDV, ESV) and LVEF from 99m Tc-MIBI GSPECT and 18 F-FDG GPET in LVA patients, using CMR as a gold standard. Additionally, we analyzed the impacts of SPD, the residual viable myocardium, and the number of akinetic/ dyskinetic segments on the accuracy of LV volumes and LVEF measured by both GSPECT and GPET.…”

Cardiac PET Perfusion: Prognosis, Risk Stratification, and Clinical Management

“…Left ventricular ejection fraction measured routinely and accurately with N-13 ammonia 9 and Rubidium-82 PET, 10–12 is a well-established risk-marker in many clinical settings. Indeed, with short-acting radiotracers such as Rubidium-82, rest, peak hyperemic LVEF and LVEF reserve (stress LVEF minus rest LVEF) can be measured, as opposed to SPECT MPI wherein LVEF is measured on the post-stress images (~15–60 minutes post stress).…”

Single photon emission computed tomography: An alternative imaging modality in left ventricular evaluation

“…Border detection becomes more complicated in apical defects, it has been forced the wall to be a smooth connection between noninfarcted portions of the wall (Faber et al 1999). Finally, positron emission tomography from nuclear studies has been used accurately for global and regional detection of LV function (Kanayama et al 2007). It has given an acceptable result for LV volumes and EF in comparison with MRI and angiography (Schae-fer et al 2003).…”