Comparison of Global and Regional Abnormalities in 99mTc-sestamibi and Cardiac Magnetic Resonance Imaging in Dilated Cardiomyopathy

Shiraki, Katsunori; Satoh, Hiroshi; Saitoh, Takeji; Saotome, Masao; Urushida, Tsuyoshi; Katoh, Hideki; Takehara, Yasuo; Sakahara, Harumi; Hayashi, Hideharu

doi:10.1016/j.cardfail.2010.03.004

Cited by 13 publications

(5 citation statements)

References 31 publications

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“…However, one publication has revealed subclinical LV dysfunction to be more frequent in psoriatic arthritis (PsA) . A number of imaging techniques, including echocardiography, magnetic resonance imaging, and scintigraphy, have been used in the assessment of LV systolic function . Ejection fraction (EF), tissue Doppler imaging (TDI), Doppler strain and, recently, speckle tracking echocardiography (STE) have been commonly used in the assessment of LV function .…”

Section: Introductionmentioning

confidence: 99%

Assessment of subclinical left ventricular dysfunction in patients with psoriasis by speckle tracking echocardiography: A Speckle Tracking Study

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Assessment of subclinical left ventricular dysfunction in patients with psoriasis by speckle tracking echocardiography: A Speckle Tracking Study

et al. 2015

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“…It is accepted that isolated MS does not impair left ventricular (LV) systolic function [3], but in some publications it has been shown that MS impairs LV systolic function [4,5,6]. In the assessment of LV systolic function, a number of imaging techniques – such as echocardiography, MRI, scintigraphy and CT – have been used [7,8,9]. In the echocardiographical assessment of LV function, the ejection fraction (EF), tissue Doppler imaging (TDI), Doppler strain, and 2D strain have been widely used [10,11,12].…”

Section: Introductionmentioning

confidence: 99%

Severity of Mitral Stenosis and Left Ventricular Mechanics: A Speckle Tracking Study

et al. 2011

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Background: It has been shown that mitral stenosis (MS) impairs left ventricular (LV) systolic function; however, this issue has not been studied comprehensively. We aimed to evaluate the role of 2D strain in the assessment of subclinical LV systolic dysfunction in patients with MS. Methods: Seventy-two patients with isolated MS (mild, moderate and severe) and 31 healthy control subjects constituted the study population. 2D echocardiography images were obtained from LV apical 4-chamber (4C), long axis (LAX), and 2-chamber (2C) views. Peak longitudinal strain and strain rate (Sr) were obtained from 4C, LAX, and 2C views. Global strain and Sr were calculated by averaging the three apical views. Results: There were no significant differences in LV ejection fraction and LV systolic or diastolic dimensions between the groups. Patients with MS had significantly lower LV longitudinal strain and Sr measurements than the control group. In addition, there were no significant differences in MS subgroups with respect to LV strain and Sr measurements. Conclusion: We demonstrated that patients with MS had lower LV functions using 2D strain imaging, and this is independent of the hemodynamic severity of MS. In the detection of subclinical LV dysfunction in patients with MS, 2D strain imaging appears to be useful.

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“…The various heterogeneous distributions in myocardial perfusion images (MPI) of 99m Tc-methoxyisobutylisonitrile (MIBI) are observed in patients with cardiac diseases. For relatively prominent and localized myocardial perfusion abnormalities, it is possible to express the extent of myocardial damage using the summed rest score (SRS) of quantitative perfusion single-photon emission computed tomography (QPS) [ 1 , 2 ]. However, even in cases with an SRS of 0–4, judged as normal or very-mild perfusion abnormality, heterogeneous perfusion might be visually observed, and no index to evaluate such subtle heterogeneous abnormality has been established.…”

Section: Introductionmentioning

confidence: 99%

Novel indices representing heterogeneous distributions of myocardial perfusion imaging

Chimura,

Ohtani,

Sera

et al. 2024

Ann Nucl Med

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Introduction Heterogeneous distribution in myocardial perfusion images (MPI) obtained by scintigraphy is often observed in cardiac diseases with normal myocardial perfusion. However, quantitative assessments of such heterogeneity have not been established. We hypothesized that the heterogeneity in MPI can be quantitatively evaluated through histogram analysis, calculating the standard deviation (SD), the 95% bandwidth (BW95%), and entropy. Methods We examined resting 99mTc-MIBI images in 20 healthy subjects and 29 patients with cardiac disease who had none or very-mild reduced myocardial perfusion evaluated as a low summed rest score (0 to 4, the range of the studied healthy subjects). Two nuclear medicine specialists blindly divided them into two groups: non-heterogeneity or heterogeneity group, based solely on their visual assessments of heterogeneity on splash and polar maps generated from single-photon emission computed tomography (SPECT) images. The %uptake was determined by dividing the tracer count of each pixel by the tracer count of the pixel with the highest value in the LV myocardium. SD, BW95%, and entropy from histogram patterns were analyzed from the polar map data array of each %uptake. We investigated whether heterogeneity could be assessed using SD, BW95, and entropy in two groups classified by visual assessments. Additionally, we evaluated the area under the curve (AUC) to identify heterogeneity in the receiver operating characteristic curve analysis. Results Based solely on visual assessments, 11 (22%) and 38 (78%) cases were classified into the non-heterogeneity and heterogeneity groups, respectively. The non-heterogeneity group consisted of only healthy subjects, and all patients with cardiac disease were classified into the heterogeneity group. The cases in the heterogeneity group had significantly higher values of heterogeneity indices (SD, BW95%, and entropy) in %uptake than those in the non-heterogeneity group (p < 0.05 for all). The AUCs of the heterogeneity indices were sufficiently high (AUCs > 0.90 for all) in distinguishing cases with visually heterogeneous distribution or patients with cardiac disease. Conclusions Heterogeneity in MPI can be evaluated using SD, BW95%, and entropy through histogram analysis. These novel indices may help identify patients with subtle myocardial changes, even in images that show preserved perfusion (345/350).

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Comparison of Global and Regional Abnormalities in 99mTc-sestamibi and Cardiac Magnetic Resonance Imaging in Dilated Cardiomyopathy

Cited by 13 publications

References 31 publications

Assessment of subclinical left ventricular dysfunction in patients with psoriasis by speckle tracking echocardiography: A Speckle Tracking Study

Assessment of subclinical left ventricular dysfunction in patients with psoriasis by speckle tracking echocardiography: A Speckle Tracking Study

Severity of Mitral Stenosis and Left Ventricular Mechanics: A Speckle Tracking Study

Novel indices representing heterogeneous distributions of myocardial perfusion imaging

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