Comparison of Glycated Albumin (GA) and Glycosylated Hemoglobin (A1C) in monitoring glycemic excursions during pregnancy

Seshiah, V.; Balaji, Vijayam; Srinivasan, Ashalatha; Balaji, Madhuri S.; Arthi, T.

doi:10.4236/ojog.2013.31011

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…7 Seshiah and colleagues found that the mean age was 27.10±4.05 years and 23.80±3.61 years in case and control group respectively, which is also comparable with the present study. 9 On the other hand, Sugawara and colleagues conducted a study which found the mean age was 35.1±4.6 years in patients with gestational diabetes mellitus and 34.9±3.5 years in control group, which is higher than the present study. 10 The higher mean age obtained by the above authors maybe due to striking variations in ethnicity, geographical variations, racial, and genetic causes may have significant influence on gestational diabetes mellitus in their study subjects.…”

Section: Discussioncontrasting

confidence: 78%

Association of Glycosylated Albumin Level with Gestational Diabetes Mellitus

Islam,

Kazal,

Haque

et al. 2021

J Chittagong Med Coll Teachers Ass

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Background: Gestational Diabetes Mellitus (GDM) is a common medical disorder detected during pregnancy with adverse consequences on the health of the mother and the fetus. Glycosylated hemoglobin (HbA1c) is an important parameter of glycemic control in patients with diabetes mellitus. However, it only reflects the long-term glycemic status, but can’t reflect short term glycemic control. It has also been demonstrated that HbA1c does not reflect glycemic control accurately during pregnancy because of iron deficiency. But Glycosylated Albumin (GA) reflects average blood glucose within 2-3 weeks and is not influenced by iron deficiency. Therefore, glycosylated albumin may be used to measure recent changes in blood glucose level in GDM patients. The aim of the study is to evaluate the association of glycosylated albumin and glycemic status in GDM. Materials and methods: This case control study was carried out in the Department of Obstetrics & Gynecology, Bangabandhu Sheikh Mujib Medical University, BSMMU, Dhaka between August 2017 and December 2018. Atotal of 140 pregnant women between 18-35 years of age attending outdoor antenatal clinic in their second and third trimester of pregnancy were enrolled in this study. Among them 70 diagnosed case of GDM were considered as group I and rest 70 non-diabetic pregnant women were considered as control and group II. Plasma glycosylated albumin was measured in all of these patients. Statistical analysis of the results was obtained by using Windows based computer software devised with Statistical Packages for Social Sciences (SPSS-22). Results: The mean glycosylated albumin was 17.12±2.00 (%) in group I and 12.90±1.03 (%) in group II. The difference was statistically significant (p<0.05) between two groups. There was a positive significant moderate correlation (r=0.643, p=0.001) between glycosylated albumin (%) and 2 hours after 75 gm glucose in GDM patients. There was also a positive significant weak correlation (r=0.258, p=0.031) between GA and FBS in GDM patients. Conclusion: A significant positive association was found between glycemic status in GDM and maternal glycosylated albumin levels. Therefore,glycosylated albumin may be applied to reflect the average blood glucose status in pregnant women with GDM. JCMCTA 2021 ; 32 (2) : 64-69

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Section: Discussioncontrasting

confidence: 78%

Association of Glycosylated Albumin Level with Gestational Diabetes Mellitus

Islam,

Kazal,

Haque

et al. 2021

J Chittagong Med Coll Teachers Ass

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A Comparison of Biomarkers in the Assessment of Glycemic Control in Diabetes: Reviewing the Evidence

Sameer

Banday

Nissar

et al. 2019

CDR

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Background: Diabetes Mellitus (DM) is a chronic life-long progressive multisystem heterogeneous metabolic disorder with complex pathogenesis. Introduction: Hyperglycemia is not only one of the classical signs of DM, but it also serves as the pivotal prerequisite for the diagnosis of the disease. However, with the advancement in the field of analytical biochemistry, a number of alternative and specific biomarkers have been discovered which can be used for better diagnosis of the DM. In this review, we have discussed various aspects of DM and different biomarkers used in assessing glycemia. Methodology: A thorough literature survey was conducted to identify various studies that reported the use of conventional and non-conventional markers for the assessment of glycemia in DM patients. Conclusion: The accurate detection and hence diagnosis of DM has become easy and more specific with the use of various biomarkers.

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Glycated Albumin – More Than the Missing Link in the Evaluation of Diabetes Control

Dinu

Moţa

2014

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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Diabetes mellitus represents a major public health problem in the world and glycemic control is very important in subjects with diabetes. Glycation of many proteins is increased in subjects with diabetes compared with persons without diabetes. Glycated albumin (GA) has emerged as a possible glycation index for intermediate-term diabetescontrol. There is evidence that GA can be considered a better parameter than glycated haemoglobin in many conditions including pregnancy, chronic kidney disease, liver diseases and anemia. Several reports indicate that GA plays a role in the pathogeny of diabetes complications, mainly in diabetic nephropathy and retinopathy. There are several limitations for using GA including the lack of standardization in the laboratories. Several studies are needed in order to understand the place of GA in the pathogeny of diabetes complications and the role in assessing the metabolic control.

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Comparison of Glycated Albumin (GA) and Glycosylated Hemoglobin (A1C) in monitoring glycemic excursions during pregnancy

Abstract: ABSTRACT

Cited by 3 publications

References 20 publications

Association of Glycosylated Albumin Level with Gestational Diabetes Mellitus

Association of Glycosylated Albumin Level with Gestational Diabetes Mellitus

A Comparison of Biomarkers in the Assessment of Glycemic Control in Diabetes: Reviewing the Evidence

Glycated Albumin – More Than the Missing Link in the Evaluation of Diabetes Control

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