Comparison of glycogen store in two strains of rat and guinea-pig under fed and fasted conditions

Fréminet, A.; Dallevet, G.; Guillet-Deniau, Isabelle; Minaire, Y

doi:10.1016/0300-9629(84)90707-2

Cited by 2 publications

(1 citation statement)

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“…Determination of the concentration of glycogen in the rat liver after 48 h of fasting showed that it was at a very low level: 2.94 ± 0.04 mg/g (14.7 μM/g) of the wet weight of the liver ( Figure 1 a). Similar data for the concentration of glycogen in the liver after 48 h of fasting (4–23 µM/g of wet weight of the liver) were obtained in other works [ 23 , 26 , 27 , 28 , 29 ].…”

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confidence: 87%

Dynamics of the Glycogen β-Particle Number in Rat Hepatocytes during Glucose Refeeding

Bezborodkina

Степанов

Vorobev

et al. 2022

IJMS

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Glycogen is an easily accessible source of energy for various processes. In hepatocytes, it can be found in the form of individual molecules (β-particles) and their agglomerates (α-particles). The glycogen content in hepatocytes depends on the physiological state and can vary due to the size and number of the particles. Using biochemical, cytofluorometric, interferometric and morphometric methods, the number of β-particles in rat hepatocytes was determined after 48 h of fasting at different time intervals after glucose refeeding. It has been shown that after starvation, hepatocytes contain ~1.6 × 108 β-particles. During refeeding, their number of hepatocytes gradually increases and reaches a maximum (~5.9 × 108) at 45 min after glucose administration, but then quickly decreases. The data obtained suggest that in cells there is a continuous synthesis and degradation of particles, and at different stages of life, one or another process predominates. It has been suggested that in the course of glycogenesis, pre-existing β-particles are replaced by those formed de novo. The main contribution to the deposition of glycogen is made by an increase in the glucose residue number in its molecules. The average diameter of β-particles of glycogen during glycogenesis increases from ~11 nm to 21 nm.

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