Comparison of gravimetric and a double-indicator dilution technique for assessment of extra-vascular lung water in endotoxaemia

Rossi, P.; Oldner, Anders; Wanecek, Michael; Leksell, L; Rudehill, A.; Konrad, David; Weitzberg, Eddie

doi:10.1007/s00134-002-1604-z

Cited by 10 publications

(3 citation statements)

References 33 publications

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“…The transpulmonary thermodilution method using the single-indicator transpulmonary thermodilution technique (PiCCO; Pulsion Medical Systems, Munich, Germany) was originally developed in swine and has been previously validated by comparison with the postmortem gravimetric technique, and with the double dilution (thermo-dye) technique in swine, sheep and humans in a variety of disease states [ 15 - 18 ]. The technique can slightly overestimate EVLWI in normal controls and underestimate it in severe lung injury.…”

Section: Methodsmentioning

confidence: 99%

Resuscitation of haemorrhagic shock with normal saline vs. lactated Ringer's: effects on oxygenation, extravascular lung water and haemodynamics

et al. 2009

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Introduction Pulmonary oedema and impairment of oxygenation are reported as common consequences of haemorrhagic shock and resuscitation (HSR). Surprisingly, there is little information in the literature examining differences in crystalloid type during the early phase of HSR regarding the development of pulmonary oedema, the impact on oxygenation and the haemodynamic response. These experiments were designed to determine if differences exist because of crystalloid fluid type in the development of oedema, the impact on oxygenation and the haemodynamic response to fluid administration in early HSR.

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Section: Methodsmentioning

confidence: 99%

Resuscitation of haemorrhagic shock with normal saline vs. lactated Ringer's: effects on oxygenation, extravascular lung water and haemodynamics

et al. 2009

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“…After termination of the ET‐1‐challenge, plasma HBP tended to decrease. When the lungs were extracted, 90 min after termination of the infusion, EVLWI Grav seemed to be increased (8.2 ± 1.1 ml/kg, Table ) when compared to values from non‐endotoxemic sham animals (6.4 ± 0.3 ml/kg) presented previously from our group . ET‐1‐infusions also induced an increase in MPAP, reduced C rs I, CI and a‐pH but had no effects on P/F ratio and other parameters shown in Table .…”

Section: Resultsmentioning

confidence: 44%

Heparin-binding protein (HBP/CAP37) - a link to endothelin-1 in endotoxemia-induced pulmonary oedema?

Persson

Halldorsdottir

Lindbom

et al. 2014

Acta Anaesthesiol Scand

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“…We tried to eliminate this factor by visually inspecting each dilution curve for artefacts or other signs of inadequate measurement. The TPDD is considered the clinical gold standard to measure EVLWI based on different studies showing strong correlation between EVLWI tpdd and EVLWI grav [12–18, 34–36]. However, as a strong correlation does not necessary imply good agreement between two methods [28], we reviewed some previous reports and (re)calculated bias and precision if the necessary data were available (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Estimation of extravascular lung water using the transpulmonary ultrasound dilution (TPUD) method: a validation study in neonatal lambs

Vrancken

Nusmeier

Hopman

et al. 2015

J Clin Monit Comput

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Increased extravascular lung water (EVLW) may contribute to respiratory failure in neonates. Accurate measurement of EVLW in these patients is limited due to the lack of bedside methods. The aim of this pilot study was to investigate the reliability of the transpulmonary ultrasound dilution (TPUD) technique as a possible method for estimating EVLW in a neonatal animal model. Pulmonary edema was induced in 11 lambs by repeated surfactant lavages. In between the lavages, EVLW indexed by bodyweight was estimated by TPUD (EVLWItpud) and transpulmonary dye dilution (EVLWItpdd) (n = 22). Final EVLWItpud measurements were also compared with EVLWI estimations by gold standard post mortem gravimetry (EVLWIgrav) (n = 6). EVLWI was also measured in two additional lambs without pulmonary edema. Bland–Altman plots showed a mean bias between EVLWItpud and EVLWItpdd of −3.4 mL/kg (LOA ± 25.8 mL/kg) and between EVLWItpud and EVLWIgrav of 1.7 mL/kg (LOA ± 8.3 mL/kg). The percentage errors were 109 and 43 % respectively. The correlation between changes in EVLW measured by TPUD and TPDD was r2 = 0.22. Agreement between EVLWI measurements by TPUD and TPDD was low. Trending ability to detect changes between these two methods in EVLWI was questionable. The accuracy of EVLWItpud was good compared to the gold standard gravimetric method but the TPUD lacked precision in its current prototype. Based on these limited data, we believe that TPUD has potential for future use to estimate EVLW after adaptation of the algorithm. Larger studies are needed to support our findings.

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Comparison of gravimetric and a double-indicator dilution technique for assessment of extra-vascular lung water in endotoxaemia

Cited by 10 publications

References 33 publications

Resuscitation of haemorrhagic shock with normal saline vs. lactated Ringer's: effects on oxygenation, extravascular lung water and haemodynamics

Resuscitation of haemorrhagic shock with normal saline vs. lactated Ringer's: effects on oxygenation, extravascular lung water and haemodynamics

Heparin-binding protein (HBP/CAP37) - a link to endothelin-1 in endotoxemia-induced pulmonary oedema?

Estimation of extravascular lung water using the transpulmonary ultrasound dilution (TPUD) method: a validation study in neonatal lambs

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