Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus

Lee, Seungcheol; Moon, Chan Sam; Sul, Donggeun; Lee, Ji-Young; Bae, Minyoung; Hong, Young Ki; Lee, Min; Choi, Sun-Ah; Derby, Richard; Kim, Byung Jo; Kim, Juhan; Yoon, Joonsung; Wolfer, Lee R.; Kim, Jaemin; Wang, Joon Ho; Hwang, Sun Wook; Lee, Sang‐Heon

doi:10.1016/j.clinbiochem.2009.06.017

Cited by 121 publications

(101 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Disc degeneration in vivo is a process resulting from years of increased catabolism of the disc matrix involving various cytokines which upregulate proteases (Lee et al, 2009;Cuellar et al, 2010;Shamji et al, 2010;. If a bioactive agent is to reverse and/or retard the degenerative process in the disc, it should be able to exert its anabolic effect in this inflammatory milieu.…”

Section: Discussionmentioning

confidence: 99%

Best Paper NASS 2013: Link-N can stimulate proteoglycan synthesis in the degenerated human intervertebral discs

Gawri¹,

Antoniou²,

Ouellet³

et al. 2013

eCM

View full text Add to dashboard Cite

Intervertebral disc (IVD) degeneration is the most common cause of back pain. Presently there is no medical treatment, leaving surgery as the only offered option. Here we evaluate the potential of Link-N to promote extracellular matrix regeneration in human IVDs. Human disc cells cultured in alginate and intact human discs were exposed to a combination of Link-N and 35 SO 4 in the presence or absence of interleukin (IL)-1, and the effect on proteoglycan synthesis was evaluated. In addition, message levels of aggrecan, matrix metalloproteinase (MMP)-3, MMP-13, a Disintegrin And Metalloproteinase with Thrombospondin Motifs (ADAMTS)-4 and ADAMTS-5 were evaluated in alginate cultures. Human disc cells responded in a dose dependent manner with maximal proteoglycan synthesis at 1 µg/mL Link-N. Link-N treatment also induced proteoglycan synthesis in intact human discs, and a prolonged effect was found up to one week after Link-N treatment. Message levels of proteinases were decreased by Link-N in the presence of IL-1. Thus, Link-N can promote proteoglycan synthesis and deplete proteinase expression in adult human discs. Link-N could therefore be a promising candidate for biologically-induced disc repair, and could provide an alternative to surgical intervention for early stage disc degeneration.

show abstract

Section: Discussionmentioning

confidence: 99%

Best Paper NASS 2013: Link-N can stimulate proteoglycan synthesis in the degenerated human intervertebral discs

Gawri¹,

Antoniou²,

Ouellet³

et al. 2013

eCM

View full text Add to dashboard Cite

show abstract

“…In addition, IVD pathology (degeneration, bulging, protrusion, and extrusion) is a spectrum of disease and expression of VEGF could differ according to the stages of IVD pathology. The increase in VEGF expression has been shown to have more severe low back pain in the IVD degeneration compared with herniated disc (Lee et al, 2009). We can recognize asymptomatic individuals with IVD degeneration.…”

Section: Discussionmentioning

confidence: 96%

Association between VEGF and eNOS gene polymorphisms and lumbar disc degeneration in a young Korean population

Han¹,

Ropper²,

Teng³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

“…Lumbar radiculopathy, although initially believed to be a primary mechanical insult to the nerve root and dorsal root ganglion, is now thought to be at least partially due to inflammatory changes in the nerve root. Continuous irrigation for visualization by spinal endoscope may decrease chemical pain mediators [15,16] in the nerve root. PS is a neuromuscular disorder that may occur when the sciatic nerve is irritated or the piriformis muscle is made spastic when chemical pain mediators are affected by irrigation.…”

Section: Discussionmentioning

confidence: 99%

Piriformis syndrome after percutaneous endoscopic lumbar discectomy via the posterolateral approach

Kim

2011

Eur Spine J

View full text Add to dashboard Cite

Percutaneous endoscopic lumbar discectomy (PELD) can be performed under local anesthesia with intravenous analgesics. To define the incidence of piriformis syndrome (PS) after PELD via the posterolateral approach under local anesthesia compared to that of general patients presenting with low back pain with/without lower leg pain. The incidence and time of occurrence of positive FAIR test after PELD within a 3-month follow-up period were evaluated retrospectively, and compared with the prevalence of general patients who visited the pain clinic for LBP with/without lower leg pain. Factors that may increase the incidence of PS after PELD were also evaluated. There was no patient with positive FAIR test immediately after PELD in the operation room and before walking. The prevalence of PS in general patients was 317/2,320 (13.7%); however, the incidence of PS after PELD within a 3-month follow-up period was 61/151 (40.4%), peaking at 32 days. High anxiety scale scores during operation led to increased incidence of PS after PELD. PELD under local anesthesia with high level of anxiety may increase the incidence of PS after walking, peaking around the first month, compared with the results for general patients with low back pain with/without lower leg pain.

show abstract

Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus

Cited by 121 publications

References 29 publications

Best Paper NASS 2013: Link-N can stimulate proteoglycan synthesis in the degenerated human intervertebral discs

Best Paper NASS 2013: Link-N can stimulate proteoglycan synthesis in the degenerated human intervertebral discs

Association between VEGF and eNOS gene polymorphisms and lumbar disc degeneration in a young Korean population

Piriformis syndrome after percutaneous endoscopic lumbar discectomy via the posterolateral approach

Contact Info

Product

Resources

About