Comparison of hearing outcomes in stapedotomy with fat and Hyaluronic acid gel as a sealing material: a prospective double-blind randomized clinical trial

Faramarzi, Mohammad; Roosta, Sareh; Faramarzi, Ali; Asadi, Mohammad

doi:10.1007/s00405-020-06554-y

Cited by 6 publications

(11 citation statements)

References 40 publications

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“…He is interested in the field of stapes surgery. 4 , 5 , 12 The research was approved by the Ethics Committee of the Shiraz University of Medical Sciences (ethics code: IR.SUMS.MED.REC.1399.263). All the patients with otosclerosis who underwent primary stapedotomy using fluoroplastic Causse loop piston or Matrix prostheses were included in the study.…”

Section: Methodsmentioning

confidence: 99%

Evaluating hearing results in stapedotomy: Comparison of fluoroplastic Causse loop piston and Matrix prosthesis

Faramarzi

Pedramfard

Roosta

et al. 2021

Laryngoscope Investig Oto

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Objective: We carried out this research to assess and compare post-stapedotomy hearing results of Matrix titanium prosthesis with a Teflon piston prosthesis, specifically the fluoroplastic (Teflon) Causse loop piston prosthesis in patients who suffered from otosclerosis.Methodology: In this retrospective study, Causse loop piston prosthesis was used in 81 ears, and the Matrix prosthesis was applied in 44 ears. For pairwise matching with Matrix prosthesis, 44 out of 81 Causse loop piston-treated ears were selected based on preoperative audiometric data. Then, postoperative audiometric results of these two groups were compared. The main outcomes were pure tone audiometric results and airbone gap (ABG) closure before and after the surgery. Incidence of postoperative sensorineural hearing loss was also evaluated and compared between the two groups. Results:The results revealed no significant difference in improvement of speech reception threshold, mean air conduction, bone conduction gain, ABG closure, and incidence of postoperative sensorineural hearing loss at the frequencies of 0.5-4 kHz between the two groups. However, performance of Matrix prosthesis was better in ABG closure at a frequency of 250 Hz. Conclusion:Herein, similar postoperative improvement was achieved at the frequencies of 0.5-4 kHz; nevertheless, Matrix provided better ABG closure at frequency of 250 Hz in short term.

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Section: Methodsmentioning

confidence: 99%

Evaluating hearing results in stapedotomy: Comparison of fluoroplastic Causse loop piston and Matrix prosthesis

Faramarzi

Pedramfard

Roosta

et al. 2021

Laryngoscope Investig Oto

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“…The authors found that HA did not affect the spiral ganglion neurons, which had even preserved the dendrite and axon histology [10]. Other articles also noted that HA lacks any toxic effects on the inner ear [3,11]. Given the safety profile, many studies have used HA to reduce friction forces during electrode insertion and to keep a seal on the perilymph inside the cochlea following electrode insertion [11][12][13][14].…”

Section: Soft Surgerymentioning

confidence: 99%

“…Other articles also noted that HA lacks any toxic effects on the inner ear [3,11]. Given the safety profile, many studies have used HA to reduce friction forces during electrode insertion and to keep a seal on the perilymph inside the cochlea following electrode insertion [11][12][13][14]. Although HA reduces friction and seals off the perilymph, some studies revealed no significant benefit with respect to hearing preservation [15].…”

Section: Soft Surgerymentioning

confidence: 99%

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Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review

et al. 2022

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Hearing loss is the most common neurosensory disorder, and with the constant increase in etiological factors, combined with early detection protocols, numbers will continue to rise. Cochlear implantation has become the gold standard for patients with severe hearing loss, and interest has shifted from implantation principles to the preservation of residual hearing following the procedure itself. As the audiological criteria for cochlear implant eligibility have expanded to include patients with good residual hearing, more attention is focused on complementary development of otoprotective agents, electrode design, and surgical approaches. The focus of this review is current aspects of preserving residual hearing through a summary of recent trends regarding surgical and pharmacological fundamentals. Subsequently, the assessment of new pharmacological options, novel bioactive molecules (neurotrophins, growth factors, etc.), nanoparticles, stem cells, and gene therapy are discussed.

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“…Figure 1 shows the PRISMA algorithm. Six studies were included in the review [20][21][22][23][24][25]. Characteristics of the studies are summarized in Table 2.…”

Section: Selection and Studies Inclusionmentioning

confidence: 99%

Comparison of different oval window sealing materials in stapes surgery: systematic review and meta-analysis

Scarpa

Marra

Ralli

et al. 2022

Eur Arch Otorhinolaryngol

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Objective To compare the efficacy and safety characteristics of different materials used for oval window sealing during stapedotomy. Methods A systematic review was conducted according to the PRISMA guidelines. Published international English literature from January 1, 2000 to December 2021 was screened, checking for studies that compared different materials utilization in patients undergoing stapedotomy surgery for otosclerosis or congenital stapes fixation. Data related to the efficacy and safety of each material were extracted. The primary outcome measure was the air–bone gap (ABG) closure after surgical intervention. Results Six studies were included in the metanalysis. Because of the heterogeneity of the treatments adopted, we assessed the use of the fat compared to all other treatments, and the use of the gelfoam compared to all other treatments. In the former analysis (fat vs others) we did not identify differences in ABG closure between the groups (p = 0.74), with a low heterogeneity of the results (I2 = 28.36%; Hedge’s g = 0.04, 95% CI − 0.19 0.27); similarly, we did not identify differences between the use of gelfoam and other treatments (p = 0.97), with a low heterogeneity of the results (I2 = 28.91%; Hedge’s g = 0.00, 95% CI − 0.20 0.21). Conclusions Numerous options are available for oval window sealing during stapedotomy, with acceptable safety and effectiveness profiles. Based on the current data, no definitive recommendation can be made regarding the choice of one material over another, and the convenience of sealing over no sealing at all.

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Comparison of hearing outcomes in stapedotomy with fat and Hyaluronic acid gel as a sealing material: a prospective double-blind randomized clinical trial

Cited by 6 publications

References 40 publications

Evaluating hearing results in stapedotomy: Comparison of fluoroplastic Causse loop piston and Matrix prosthesis

Evaluating hearing results in stapedotomy: Comparison of fluoroplastic Causse loop piston and Matrix prosthesis

Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review

Comparison of different oval window sealing materials in stapes surgery: systematic review and meta-analysis

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