Comparison of Heidelberg Retina Tomograph with disc‐macula distance to disc diameter ratio in diagnosing optic nerve hypoplasia

Pang, Yi; Frantz, Kelly A.

doi:10.1111/opo.12274

Cited by 7 publications

(3 citation statements)

References 40 publications

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“…Yet this DM:DD ratio varies with age, race, and gender. 6 Most clinicians believe that neither this DM:DD ratio, nor other clinical signs (e.g., double-ring sign, vascular signs) are pathognomonic for ONH. 2 Thus, diagnosing and rating severity of ONH is difficult.…”

Section: Introductionmentioning

confidence: 99%

<p>Optic Nerve Hypoplasia: A Retrospective Analysis of Clinical Presentation and Disease Severity</p>

Netzel¹,

High²,

Suh³

2019

OPTH

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Purpose: Through the establishment of relationships between optic nerve hypoplasia (ONH), optical coherence tomography (OCT) spectralis retinal nerve fiber layer (RNFL) thickness results and clinical sequelae, this study aims to identify long-term outcomes for individuals with ONH. Methods: A retrospective review of pediatric ophthalmology patients at Children's Hospital of Omaha from January 2000 to October 2018 was performed. All patients with ONH evaluated with Heidelberg Engineering's OCT Spectralis were identified. Patient records were investigated for visual acuity, presence of nystagmus, strabismus, and endocrinopathies. Statistical analysis with linear regression models, random intercepts models, and odds ratios were used to define relationships between RNFL thickness at the optic nerve head, nystagmus, strabismus, and endocrine dysfunction. Results: There exists a strong trend of worsening visual acuity as RNFL thickness at the optic nerve head decreases in all scanned regions. This is strongest at the temporal-superior (p=0.009) and nasal-inferior (p=0.006) regions in patients with bilateral ONH. There is insufficient evidence of a difference in prevalence of nystagmus or strabismus between subjects with unilateral or bilateral ONH. Endocrinopathy is present in 21.6% of the subjects, with no statistical difference in the type of endocrinopathy or laterality of ONH. Conclusion: Trends established indicate that best-corrected visual acuity is related to RNFL thickness at the optic nerve head. Odds ratios for the prevalence of nystagmus also point to RNFL thickness as a contributing factor. These trends may have the potential to characterize ONH severity by objective measurement of clinical outcomes and RNFL thickness at the optic nerve head.

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Section: Introductionmentioning

confidence: 99%

<p>Optic Nerve Hypoplasia: A Retrospective Analysis of Clinical Presentation and Disease Severity</p>

Netzel¹,

High²,

Suh³

2019

OPTH

View full text Add to dashboard Cite

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“…The special issue also emphasised fundamental research questions that can be addressed with imaging. These included diurnal changes in ocular tissues, 5 the use of imaging to understand and diagnose retinal disease 3,6,7 and the extent to which the brain changes its structure and function in individuals with macular degeneration or glaucoma. 8,9 In addition, contemporary themes in vision science imaging research were identified by two invited review papers featured within the special issue.…”

mentioning

confidence: 99%

Subtle changes in diabetic retinas localised in 3D using OCT

Arthur

Papay

Haggerty

et al. 2018

Ophthalmic Physiologic Optic

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“…The authors also provide case images to guide clinicians in the use of infrared reflectance imaging for the diagnosis of AMD. Pang and Franz demonstrate that the Heidelberg Retinal Tomograph (HRT) has higher sensitivity and specificity for detecting congenital optic nerve hypoplasia than the standard measurement of disc‐to‐macula/disc diameter ratio . An optimal HRT disc area cut‐off value for distinguishing between optic nerve hypoplasia and a healthy optic nerve head is also provided.…”

mentioning

confidence: 99%