Comparison of Hibiscus sabdariffa L. Extract and Enalapril with Regard to Their Effect on Lung Fibrosis in a Bleomycin-induced Rat Model of Lung Fibrosis

Hemmeti, Ali Asghar; Khodayar, Mohammad Javad; Malayeri, Alireza; Nooshabadi, Mohammad Ali Rashidi; Ranjbari, Nastaran; Nooshabadi, Mohammadreza Rashidi

doi:10.17795/jjnpp-38798

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…Protective effects of M. oleifera on lung functions, hematological damage, and lipid damage induced by heavy metals have been demonstrated using experimental rats. Ameliorative effects of H. sabdariffa on pulmonary fibrosis and chronic inflammatory interstitial lung disease have also been studied using rats exposed to a toxic chemical (Hemmeti et al 2016, Ajibade et al 2021. It has been demonstrated that pre-treatment using Z. officinale extract improves lung function and normalizes lung injuries in alcoholic humans and rats exposed to polychlorinated biphenyls (Alireza et al 2017, Ahd et al 2019.…”

Section: Discussionmentioning

confidence: 99%

Selected Vegetables and Spices Improve DNA Quality and Histopathological Abnormalities in Roof Rats (Rattus rattus) Exposed to Cement Dust

Yahaya,

Salisu,

Musa

et al. 2023

FMI

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Highlights: 1. This study identified feasible and affordable alternatives to ineffective conventional cement production pollution control strategies.2.M. oleifera, H. sabdariffa, T. occidentalis, and Z. officinale are effective as personal interventions to ameliorate the effects of cement pollution. Abstract Conventional pollution control strategies in the cement industry have proven ineffective. As a result, effective and targeted complementary interventions are necessary. This study used roof rats (Rattus rattus) inhabiting the premises of a cement plant in Sagamu, Ogun State, Nigeria, to evaluate the ameliorative effects of moringa (Moringa oleifera), roselle (Hibiscus sabdariffa), fluted pumpkin (Telfairia occidentalis), and ginger (Zingiber officinale) on cement dust exposure. A total of 42 rats were divided into seven groups, with each group consisting of six rats. Group 1 served as the negative control group and was not exposed to any substances, while group 2 served as the positive control group and received standard feed throughout the experiment. Meanwhile, groups 3, 4, 5, 6, and 7 served as the experimental group. Rats in these groups were fed with 400 mg/kg of ethanolic extracts of Z. officinale, M. oleifera, T. occidentalis, H. sabdariffa, and a mixture of the four extracts with a composition of 1:1:1:1, respectively, for 90 days. The plasma DNA concentrations, DNA purity, and lungs of the rats were examined before and after the experiment. Prior to the experiment, the exposed rats had higher plasma DNA concentrations and lower DNA purity, as well as severe fibrosis and congested alveoli in their lungs, compared to the unexposed rats. At the end of the experiment, the experimental groups showed a significant increase in DNA purity (p≤0.05) and a decline in plasma DNA concentrations compared to the positive control group. In addition, the experimental groups showed fewer histopathological abnormalities than the positive control group. The mixture of the extracts yielded the most favorable results, followed by the extracts of Z. officinale, M. oleifera, T. occidentalis, and H. sabdariffa, respectively. These findings suggested that the selected vegetables and spices have the properties to ameliorate the effects of cement dust exposure. Therefore, individuals residing in close proximity to cement plants are encouraged to consume these vegetables and spices.

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