Comparison of high and low doses of suxamethonium

Abstract

SummaryIn a double-blind study, 67 young adult patients undergoing anaesthesia for dental extractions were allocated at random to receive either 0.5 mglkg or 1.5 rnglkg suxamethonium. A greater increase in arterial pressure was seen following induction in the 1.5 mgikg group, aIthough overall intubating conditions were similar in the two groups. Suxamethonium-associated muscle pains were signijfcantly more common in the group which received the larger dose (p<0.05).

Intubating conditions following rapid sequence induction with three doses of succinylcholine

“…[410–12] Stewart et al . [11] reported that 26 (96%) of 27 patients receiving 1.5 mg/ kg succinylcholine and 30 (94%) of 32 patients receiving 0.5 mg/kg had acceptable intubating conditions. However, in patients with a full stomach or in those with raised intracranial pressure, excellent intubating conditions are warranted.…”

“…In contrast, Stewart et al . [11] reported that, after induction of anaesthesia with 5 mg/kg thiopental, 23 (85%) of 27 patients receiving 1.5 mg/kg succinylcholine, and 18 (56%) of 32 patients receiving 0.5 mg/kg succinylcholine had excellent intubating conditions at 60 s. Naguib et al . [12] also found the incidence of excellent intubating conditions following induction with 2 μ g/kg fentanyl and 2 mg/kg propofol to be 0.0%, 43.3%, 60.0%, 63.3%, 80.0% and 86.7% of patients after 0.0, 0.3, 0.5, 1.0, 1.5, and 2.0 mg/kg succinylcholine, respectively.…”

“…[5] noted diaphragmatic activity 5.2 (±1.5-2.0) min after succinylcholine and Stewart et al . [11] reported a 3.8 min apnoea time after 0.5 mg/kg.…”

The optimal succinylcholine dose for intubating emergency patients: retrospective comparative study

“…It minimizes the incidence of idiopathic malignant hyperthermia, myalgia, masseter spasm, rhabdomyolysis, and hemodynamic changes (10). It reduces the aggravated hyperkalemia in end-stage renal failure, burn, and potassium sparing diuretics patients (26).…”

“…It reduces the aggravated hyperkalemia in end-stage renal failure, burn, and potassium sparing diuretics patients (26). It avoids the excessive increase in intracranial pressure in head injuries and minimizes the increase in both intra-abdominal and intra-gastric pressures, decreasing the incidences of vomiting and consequent aspiration (10). …”