Comparison of high efficiency CZT SPECT MPI to coronary angiography

Duvall, W. Lane; Sweeny, Joseph; Croft, Lori B.; Barghash, Maya; Kulkarni, Nitin; Guma, Krista A.; Henzlova, Milena J.

doi:10.1007/s12350-011-9382-z

Cited by 63 publications

(42 citation statements)

References 20 publications

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Section: Discussionsupporting

confidence: 91%

“…Angiographic correlation in a subset of our cohort found an excellent sensitivity (96%), and high degree of accuracy (86%) for detecting coronary disease, which is consistent with previous publications [4] . The specificity of 50% is also consistent with previous publications on SPECT MPI [4] . This specificity may not be entirely representative of the true specificity associated with SPECT MPI, as patients with normal studies rarely proceed on to angiography, thus limiting a more robust and accurate evaluation of true negative and false negative studies [4] .…”

Section: Discussionsupporting

confidence: 91%

“…The specificity of 50% is also consistent with previous publications on SPECT MPI [4] . This specificity may not be entirely representative of the true specificity associated with SPECT MPI, as patients with normal studies rarely proceed on to angiography, thus limiting a more robust and accurate evaluation of true negative and false negative studies [4] .…”

Section: Discussionsupporting

confidence: 91%

“…Similar to previous publications, about two-thirds of our SPECT MPI studies were normal (65%), with the remaining one-third being abnormal (30%), and a small percentage (5%) being equivocal [4,6] . Angiographic correlation in a subset of our cohort found an excellent sensitivity (96%), and high degree of accuracy (86%) for detecting coronary disease, which is consistent with previous publications [4] .…”

Section: Discussionsupporting

confidence: 91%

“…New cadmium zinc telluride (CZT) imaging technology measures higher photon flux compared to standard sodium-iodide scintillation technology. It has been shown to provide excellent diagnostic quality images, while allowing for reduce isotope dosage and shorter imaging acquisition times [4][5][6] . Given the concern over radiation dose in medical imaging, our goal was to reduce radiation dose for patients requiring nuclear stress testing, while still maintaining rapid, high quality diagnostic and prognostic imaging.…”

mentioning

confidence: 99%

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Ultra low-dose single photon emission computed tomography myocardial perfusion imaging

Nelson

House

Turnquist

et al. 2014

IJDI

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Background: Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) provides excellent diagnostic and prognostic information. A primary limitation of SPECT is radiation exposure. New cadmium zinc telluride (CZT) technology has allowed for reduced radiation exposure.Methods: A cohort of 414 consecutive patients undergoing very low-dose SPECT MPI utilizing CZT technology was analyzed. Patients received rest/stress dosing strategies of 111/333, 148/444, 222/666, 296/888, 370/1110 Megabecquerels (MBq) (3/9, 4/12, 6/18, 8/24, 10/30 millicuries) depending on their weight and body mass index. Image quality was visually assessed by the reading cardiologist (scale: 1 = poor; 2 = fair; 3 = good; 4 = excellent).Results: 58% of patients received 111/333MBq, 22% received 148/444MBq, 13% received 222/666MBq, 6% received 296/888MBq, and 1% received 370/1110MBq. The estimated radiation dose was 3.6, 4.8, 7.2, 9.6, and 12 millisieverts respectively. The average image quality for the cohort was 3.3 ± 0.7. The rest/stress counts (10 3 ) for 111/333 and 148/444 groups were 532 ± 212/1718 ± 525 and 545 ± 177/1748 ± 399, while the rest/stress counts (10 3 ) for the 222/666 and 296/888 groups were 673 ± 178/2235 ± 923 and 764 ± 249/2588 ± 788 respectively. The 111/333 and 148/444 groups had significantly lower counts than the 222/666 and 296/888 groups, but only the 296/888 group had a significant difference in image quality when compared to the 111/333 group, with the 111/333 group having better image quality. Conclusion:CZT technology permits rapid, very low-dose MPI studies to be performed, thus, reducing the radiation exposure for patients, while still providing high quality, diagnostic perfusion results. The majority of our patients were imaged at less than 4mSv.

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Section: Discussionsupporting

confidence: 91%