Comparison of high-flow nasal cannula oxygen therapy and conventional reserve-bag oxygen therapy in carbon monoxide intoxication: A pilot study

Kim, Young‐Min; Shin, Hyun-Jo; Choi, Dongwon; Kim, Jimin; Lee, Suk-Woo; Jeong, Seong-Hae; Kim, Hoon

doi:10.1016/j.ajem.2019.158451

Cited by 8 publications

(12 citation statements)

References 24 publications

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“…1,2,[6][7][8] Oxygen supplementation increases the partial pressure of oxygen, which increases the dissociation rate of carbon monoxide from haemoglobin. 1,2,6 The rate of dissociation, also referred to as the rate of decay, is exponential for carboxyhaemoglobin, resulting in a more rapid decline in FCOHb following initial interventions compared with later interventions. 5 A co-oximeter is a bench-top analyser using multiple wavelength spectrophotometry to measure various types of haemoglobin (oxyhaemoglobin, deoxyhaemoglobin, carboxyhaemoglobin, and methemoglobin) in both arterial and venous blood samples.…”

Section: Discussionmentioning

confidence: 99%

“…Studies show that HFNO can significantly reduce the FCOHb level within the first hour compared with traditional oxygen therapy, and the half-life is reportedly reduced to 20-45 minutes with HFNO whereas traditional oxygen has a half-life of 70-80 minutes. [4][5][6][7][8] Additionally, patients suffering from mucosal inflammation secondary to smoke inhalation likely would benefit from the superior humidification of HFNO. 3,16 In this case report, one patient was placed on MV due to the severity of neurologic signs and overall respiratory distress.…”

Section: Discussionmentioning

confidence: 99%

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Successful treatment of carbon monoxide toxicity with high flow nasal oxygen compared to mechanical ventilation

Gazsi¹,

Goic²,

Butler

2022

Vet Record Case Reports

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Two dogs were presented to the emergency room for suspected carbon monoxide toxicity associated with a furnace malfunction. Both dogs exhibited signs of impaired ambulation, abnormal mentation, and respiratory distress. Arterial co-oximetry confirmed elevated carboxyhaemoglobin levels (27.6% and 23.6%). Initial treatment consisted of bilateral nasal oxygen administration. Due to progression of clinical signs, dog 1 was mechanically ventilated and dog 2 was administered high flow nasal oxygen (HFNO). After approximately 3 hours of treatment, both dogs had improved carboxyhaemoglobin levels of 4.9% and 5.2%, respectively, and had significant improvement of reported clinical signs. The calculated half-life of carboxyhaemoglobin in dog 1 with mechanical ventilation was 150 minutes, and in dog 2 was 167 minutes with HFNO. Both dogs survived to discharge and no long-term complications were reported. This is the first described case using HFNO as a treatment option for carbon monoxide toxicity in dogs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Successful treatment of carbon monoxide toxicity with high flow nasal oxygen compared to mechanical ventilation

Gazsi¹,

Goic²,

Butler

2022

Vet Record Case Reports

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“…While the feasibility and efficacy of HFNC use in the ED have been demonstrated in the previously discussed conditions, the benefit of HFNC over other respiratory support devices in the ED setting has not been clearly demonstrated in several diseases [ 115 ]. HFNC has been evaluated in patients with obstructive lung disease and hypercapnic respiratory failure, heart failure, and carbon monoxide toxicity [ 36 , [116] , [117] , [118] , [119] , [120] , [121] , [122] , [123] ]. In patients with hypercapnic respiratory failure associated with obstructive lung disease, studies have noted a decrease in partial pressure of carbon dioxide but no difference in intubation or mortality rates [ 116 , 117 ].…”

Section: Discussionmentioning

confidence: 99%

“…The data are also controversial for acute heart failure, with several studies finding reduction in respiratory rate and degree of dyspnea, but no difference in intubation or mortality when compared with conventional oxygen therapy [ 36 , [118] , [119] , [120] ]. For patients with carbon monoxide toxicity, studies demonstrate greater reduction in carboxyhemoglobin levels with HFNC when compared with conventional oxygen therapy [ 121 , 122 ], with one study finding two thirds of patients had a reduction by half within 40 min of HFNC therapy [ 123 ].…”

Section: Discussionmentioning

confidence: 99%

High flow nasal cannula for adult acute hypoxemic respiratory failure in the ED setting

Long

Liang

Lentz

2021

The American Journal of Emergency Medicine

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“…There are several methods to provide 100% oxygen to patients, such as a rebreathing reserve mask, high-flow nasal cannula (HFNC) oxygen and oxygen therapy with continuous positive airway pressure (CPAP) [48][49][50][51]. In Kim et al's (2019) study, HFNC did not reduce the CO half-life compared with a rebreathing reserve mask [49]. When comparing normobaric oxygen therapy with 1 h of CPAP therapy, Bal et al discovered that patients receiving CPAP therapy had a shorter CO half-life than those receiving normobaric oxygen therapy.…”

Section: % Oxygenmentioning

confidence: 99%

Factors Contributing to CO Uptake and Elimination in the Body: A Critical Review

Pan

Leonardi

Croxford

2020

IJERPH

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Background: Carbon monoxide (CO) poisoning is an important public health issue around the world. Research indicates that many factors may be related to the rate of CO uptake and elimination in the human body. However, some factors related to CO uptake and elimination are considered controversial. Relatively little attention has been devoted to review and synthesis of factors affecting CO uptake and elimination. Purpose: This paper provides a critical scoping review of the factors and divides them into four aspects, including environmental, demographic, physiological and treatment factors. Methods: We searched the scientific databases for research that has proposed a mathematical equation as a synthesis of quantities related to CO poisoning, CO elimination, CO uptake, CO half-life, CO uptake and elimination and their relationships. After excluding the studies that did not meet the study criteria, there were 39 studies included in the review and the search was completed before 16 December 2019. Results and conclusion: This review discusses most of the factors that impact the rate of CO uptake and elimination. Several factors may be related to CO uptake and elimination, such as CO concentration, the duration of exposure to CO, age, sex, exercise, minute ventilation, alveolar ventilation, total haemoglobin mass and different treatments for CO poisoning. Although some potential factors were not included in the review, the findings are useful by presenting an overview for discussing factors affecting CO uptake and elimination and provide a starting point for further study regarding strategies for CO poisoning and the environmental standard of CO.

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Comparison of high-flow nasal cannula oxygen therapy and conventional reserve-bag oxygen therapy in carbon monoxide intoxication: A pilot study

Cited by 8 publications

References 24 publications

Successful treatment of carbon monoxide toxicity with high flow nasal oxygen compared to mechanical ventilation

Successful treatment of carbon monoxide toxicity with high flow nasal oxygen compared to mechanical ventilation

High flow nasal cannula for adult acute hypoxemic respiratory failure in the ED setting

Factors Contributing to CO Uptake and Elimination in the Body: A Critical Review

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