Comparison of Hla Mismatch Scoring and the Pre-Transplant Serum Donor Specific Antibody (Dsa) Levels With Histomorphology to Predict the Antibody-Mediated Rejection as Well as the Severity of Rejection

Abstract

BACKGROUNDImmunologic studies such as Human Leukocyte Antigen (HLA) typing and measurement of the Donor Specific Antibody (DSA) titre are more helpful to assess the long-term success of renal transplantation and in a superior graft survival. Amount of HLA mismatching and the immune response against the graft determine the success of renal transplantation and graft versus host disease. Rejection can be a humoral or T-cell mediated, but the humoral rejection is more important, as it has a very few diagnostic morphological features in the biopsy and these cases are resistant to anti-rejection therapy with a worse prognosis.