BACKGROUND Diabetic foot ulcers are inevitable in 15% of diabetic patients even if they follow the diet or control blood sugar level meticulously. The mainstay of treatment for diabetes related foot ulceration is a multidisciplinary team (MDT) approach that includes metabolic control, debridement, offloading/pressure redistribution, vascular control, infection control and seamless integrated wound care. And the ulcer usually is of a chronic type. With regard to topical agents, the effectiveness of topical Insulin is considered valid and effective on wound healing process. The present study is to compare the efficacy of Topical Insulin vs. Normal Saline dressing. MATERIALS AND METHODS This is a non-randomised control study. A total of sixty patients with Diabetic foot ulcer were enrolled and the study was done in