Comparison of hydrophobic and hydrophilic intraocular lens in preventing posterior capsule opacification after cataract surgery

Zhao, Yang; Ke, Yang; Li, Jiaxin; Huang, Yang; Zhu, Siquan

doi:10.1097/md.0000000000008301

Cited by 67 publications

(65 citation statements)

References 25 publications

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“…As reported, capsule space was positively related to axial length, the longer eyes had a larger capsule [6] and the implanted IOL was thinner, which tended to have less convexity of the IOL back surface. In addition, IOL apposition to capsule was negatively correlated with axial length [15]. These factors resulted in a larger IOL-PC space and higher PCO occurrence rate which could be supported by our results as well.…”

Section: Discussionsupporting

confidence: 88%

“…As it was reported that the rapid proliferation speed of LECs for patients younger than 40 years was only 5.8 ± 0.6 days, for those who were older than 60 years was 7.2 ± 0.7 days. Hence, theoretically, LECs could migrate to and proliferate on the posterior capsule before capsular bend formation (1 month after surgery [11]) and IOL apposition to a capsule (within 2 weeks for normal eyes [13,14] and en-longed for high myopia eyes [15]). In addition, Elgohary et al [19] reported closer apposition between IOL optic and mid-peripheral posterior capsules when comparing hydrophobic acrylic IOLs and PH silicone IOLs.…”

Section: Discussionmentioning

confidence: 99%

“…With reference to medical records, patients were classi ed into different groups based on the IOL material, haptic design, haptic angulation and IOL diameter. The implanted IOLs included Bausch & Lomb ADAPT AO (33), ZEISS Bigbag (15), CT ASPHINA 603P ZO (15), Sensar AR40e (14), HQ-201hep (10).…”

Section: Participantsmentioning

confidence: 99%

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AS-OCT application in quantifying Posterior capsule opacification severity with varied IOL designs

Yu¹,

Lu²,

Guo³

et al. 2020

Preprint

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Background To evaluate application of AS-OCT in PCO severity assessment and analyse relationship between PCO severity and IOL characters. Methods PCO patients were prospectively recruited. Cross-sectional images of the anterior segment at horizontal and vertical medians were acquired with AS-OCT. The area of the IOL-PC (posterior capsular) space and PCO severity (area, thickness and density at 3 mm and 5 mm IOL optic regions) were measured. The relationship between visual acuity and PCO severity, comparisons of PCO severity and IOL-PC space using varied IOL designs were analysed. Results One hundred PCO eyes were enrolled. IOL-PC space and PCO thickness and area was positively correlated with axial length. The cut-off level of visual acuity: was 0.52 Log MAR. Visual acuity were positively correlated with PCO area and thickness when visual acuity was ≤ 0.52 Log MAR. 3-piece C haptic IOL showed a smaller PCO area and thickness than the 1-piece 3 haptic IOL and 1-piece 4 haptic IOL. PCO area and thickness values for an IOL with a diameter ≤ 11.0 mm were greater than for an IOL with a diameter of 12.5 mm. The differences were statistically significant. PCO area and thickness increased when IOL haptic angulation increased (from 0 to 12 degrees). Conclusions In PCO eyes, cut-off level of visual acuity was 0.52 Log MAR. With more severe PCO, visual acuity maybe not enough to describe the visual function impairment. PCO severity and IOL-PC space was significantly correlated with axial length and IOL design and material.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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AS-OCT application in quantifying Posterior capsule opacification severity with varied IOL designs

Yu¹,

Lu²,

Guo³

et al. 2020

Preprint

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“…The mechanisms by which the opacification was resolved are unknown. However, this fact should be considered when implanting hydrophobic lenses along with another advantage, which is the lower incidence of posterior capsule opacification compared to hydrophilic lenses …”

Section: Discussionmentioning

confidence: 99%

Systematic review of potential causes of intraocular lens opacification

Fernández

Sánchez‐García

Rodríguez‐Vallejo³

et al. 2019

Clinical Exper Ophthalmology

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Intraocular lens (IOL) opacification is an infrequent complication of cataract sur-gery. Surface analysis has demonstrated that the opacification of IOLs is related to calcium or phosphate precipitation on or within the lenses, but the associated mechanisms are unknown, and the scientific literature is heterogeneous and limited to case series and retrospective studies. The purpose of this systematic review was to analyse the most frequent conditions associated with opacification of IOLs reported by studies. A search was carried out using the PubMed MEDLINE, Web of Science and Scopus databases. The quality of the studies selected was evaluated using the Pierson tool. The search provided a total of 811 articles, of which 39 were selected following the inclusion and exclusion criteria. The most common opacified lenses were hydrophilic IOLs according to our analysis. The mean time of appearance of lens opacification was 14.93 ± 17.82 months. The most frequent conditions associated with opacification of the IOLs were Descemet Stripping with Automated Endothelial Keratoplasty (DSAEK/DSEK) and diabetes mellitus (DM), followed by pars plana vitrectomy (PPV), blood hypertension (HT), and glaucoma.Concerning the quality analysis, the mean score was 7.00 ± 1.43 (scoring range from 0 to 10), indicating an acceptable quality of the case reports and retrospective studies. In conclusion, DSAEK/DSEK, DM, PPV, glaucoma and hypertension are conditions with potential risk of IOL opacification after cataract surgery, especially when implanting hydrophilic acrylic IOLs. K E Y W O R D Sacrylic IOL, cataract surgery, intraocular lens, IOL explantation, IOL opacification

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“…Phacoemulsification is a satisfactory method for the treatment of cataract, but there are also many postoperative complications [5] [6] [7]. Posterior capsular opacification (PCO) is the most common complication after a few years of surgery [8]. Therefore, the prevention and treatment of cataract has become particularly important.…”

Section: Introductionmentioning

confidence: 99%

The Emerging Roles of Non-Coding RNAs in Cataract

Li¹,

Lei²,

Wang³

et al. 2020

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Non-coding RNAs (ncRNAs) are a large class of transcripts lacking evident protein coding potential, and play versatile roles in a diverse range of physiological and pathological processes. Mounting evidences have indicated that ncRNAs are aberrantly expressed in a wealth of diseases such as cataract. Cataract is a cloudy lens caused by radiation, age, drugs and other factors. NcRNAs, including microRNAs, long non-coding RNAs, circular RNAs, have been identified to regulate the occurrence and development of cataract. Current studies indicate that ncRNAs exert the multifaceted functions in the lens of cataract patients and have been proved as potential diagnostic biomarkers or therapeutic targets for cataracts. This review summarizes the study of relationship between the lens and ncRNAs, which can provide a novel insight into the pathogenesis of cataract.

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Comparison of hydrophobic and hydrophilic intraocular lens in preventing posterior capsule opacification after cataract surgery

Abstract: Supplemental Digital Content is available in the text

Cited by 67 publications

References 25 publications

AS-OCT application in quantifying Posterior capsule opacification severity with varied IOL designs

AS-OCT application in quantifying Posterior capsule opacification severity with varied IOL designs

Systematic review of potential causes of intraocular lens opacification

The Emerging Roles of Non-Coding RNAs in Cataract

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