Comparison of Hypoglycemic Activity of Fermented Mushroom of Inonotus obliquus Rich in Vanadium and Wild-Growing I. obliquus

Zhang, Yibing; Zhao, Yong; Cui, Haifeng; Cao, Chunyu; Guo, Jian-You; Liu, Sha

doi:10.1007/s12011-011-9043-8

Cited by 13 publications

(8 citation statements)

References 23 publications

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“…At a dose of 100 mg/kg, a 35.9% increment in tumor metastasis was observed, whereas at a dose of 10 mg/kg, there was 33.4% inhibition of tumor metastasis (Song et al, ). Additionally, a promising antidiabetic therapeutic effect has also been found with vanadium‐enriched I. obliquus (Zhang et al, ), which opens the door to the potential use of this mushroom in combination with metals and other bioactive compounds. It was further reported that the I. obliquus cultured in Tween 80 (nonionic surfactant)‐containing medium improved the production of exopolysaccharides and endopolysaccharides and increased the scavenging activity against DPPH radicals (Xu, Quan, & Shen, ).…”

Section: Limitations and Future Recommendationmentioning

confidence: 99%

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Duru

Kovaleva

Данилова

et al. 2019

Phytotherapy Research

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The use of mushrooms as functional foods and in the treatment of diseases has a long history. Inonotus obliquus is a mushroom belonging to the Hymenochaetaceae family and has possible anticancer, antiviral, and hypoglycemic properties. Chemical analysis of this mushroom has allowed the identification of various constituents such as melanins, phenolic compounds, and lanostane-type triterpenoids. A plethora of findings have highlighted the potential molecular mechanisms of actions of this mushroom such as its ability to scavenge reactive oxygen species, inhibit the growth of tumors, decrease inflammation and insulin resistance in type 2 diabetes, and stimulate the immune system. This review summarizes the relevant findings with reference to the therapeutic potential of this mushroom in countering the progression of cancers, diabetes mellitus, and antiviral activities, while highlighting its possible molecular mechanisms of action. The possible role of this mushroom as a therapeutic agent in addressing the pathogenesis of diabetes and cancer has also been suggested.

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Section: Limitations and Future Recommendationmentioning

confidence: 99%

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Duru

Kovaleva

Данилова

et al. 2019

Phytotherapy Research

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“…Among all the active components in Inonotus obliquus , Inonotus obliquus polysaccharides have the broadest biological activity, such as anticancer, hypoglycemic, anti-inflammatory, and anti-oxidation effects [ 8 , 22 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. Through the number of Scopus-indexed publication numbers (archived until 15 March 2021) for polysaccharide bioactivity, Inonotus obliquus , Inonotus obliquus polysaccharide related articles, a certain degree of upward trend can be seen ( Figure 1 ), which means that the medicinal value and health value of Inonotus obliquus have been widely recognized and affirmed [ 5 , 6 , 62 , 63 , 64 ], making it worthwhile to review Inonotus obliquus polysaccharides.…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application

Jia

Xue

et al. 2021

Polymers

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Inonotus obliquus (Chaga mushroom) is a kind of medicine and health food widely used by folk in China, Russia, Korea, and some occidental countries. Among the extracts from Inonotus obliquus, Inonotus obliquus polysaccharide (IOPS) is supposed to be one of the major bioactive components in Inonotus obliquus, which possesses antitumor, antioxidant, anti-virus, hypoglycemic, and hypolipidemic activities. In this review, the current advancements on extraction, purification, structural characteristics, and biological activities of IOPS were summarized. This review can provide significant insight into the IOPS bioactivities as their in vitro and in vivo data were summarized, and some possible mechanisms were listed. Furthermore, applications of IOPS were reviewed and discussed; IOPS might be a potential candidate for the treatment of cancers and type 2 diabetes. Besides, new perspectives for the future work of IOPS were also proposed.

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“…Because of the limitations and unmet goals associated with anti-diabetic drugs, an increased number of diabetic patients globally currently resort to complementary and alternative medicine [ 5 ]. Therefore, natural and non-toxic anti-diabetic drugs are inevitable for diabetic therapeutics such as exopolysaccharides (EPSs) [ 6 ]. Metabolic abnormalities and oxidizing stress arise at early stages of diabetes and are significant risk factors for complications of the nervous, cardiovascular, excretory, and reproductive systems [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of polysaccharide from Bacillus subtilis sp. on cardiovascular diseases and atherogenic indices in diabetic rats

Ghoneim

Hassan

Mahmoud

et al. 2016

BMC Complement Altern Med

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BackgroundDiabetes mellitus induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy, and polyneuropathy. The main aim of the study was to isolate and identify both of bacterial strain and exopolysaccharide to assess the possible efficiency of exopolysaccharide (BSEPS) from Bacillus subtilus sp .suppress on cardiovascular diseases, atherogenic and coronary risk indices in diabetic rats.MethodsThe bacterial strain used was isolated from mangrove tree sediment by serial dilution and the spread-plate technique and identified by morphological, physiological, and biochemical characteristics, and by 16S rRNA analysis. The BSEPS was extracted from the bacterial supernatant by four volumes child ethanol then the functional groups, MW and chemical analysis were detected by Fourier-transform infrared (FTIR), gel permeation chromatograph (GPC) and High-performance liquid chromatography (HPLC). Also an antioxidant activity was measured by using 2,2-diphenyl-1-picrylhydrazyl (DPPH). Thirty-two male Sprague–Dawley rats were equally randomized into four groups: control group supplemented with normal saline (Group I); the second group supplemented with BSEPS (Group II); diabetic group supplemented with normal saline (Group III) and the diabetic group supplemented with BSEPS (Group IV). Diabetes was induced by Streptozotocin (STZ) (65 mg/kg BW) intraperitoneally. BSEPS (100 mg/kg BW) was administered orally for four weeks, following STZ induction.ResultsThe isolated strain was identified based on 16S rRNA sequence as Bacillus subtilis sp. suppress. A preliminary chemical analysis of BSEPS indicated that the monosaccharides were mannuronic acid, glucuronic acid, glucose, galactose, and mannose in a molar ratio of 1.6:1.5:1.0:2.3:1.4, respectively, with a molecular weight of 1.66 × 104 g mol−1 and a molecular number of 7.64 × 103 g mol−1. BSEPS inhibited 2,2-diphenyl-1-picrylhydrazyl radical activity, and BSEPS supplement reduced glucose (p < 0.05) and troponin levels while insulin levels increased (p < 0.05). BSEPS also reduced total serum cholesterol, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), and triglycerides, and elevated high-density lipoprotein-cholesterol (HDL). In parallel, intercellular adhesion molecule (ICAM), and vascular cell adhesion molecule (VCAM) levels in STZ-induced diabetic rats were reduced. Moreover, polysaccharides reduced atherogenic and coronary risk indices, which were confirmed by histopathological examination of the heart and aorta.ConclusionsOur study suggests that BSEPS improves hyperglycemia, dyslipidemia, and cardiovascular disease risk in STZ-induced diabetic rats.

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Comparison of Hypoglycemic Activity of Fermented Mushroom of Inonotus obliquus Rich in Vanadium and Wild-Growing I. obliquus

Cited by 13 publications

References 23 publications

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application

Effect of polysaccharide from Bacillus subtilis sp. on cardiovascular diseases and atherogenic indices in diabetic rats

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