2008
DOI: 10.1016/j.jvir.2008.06.017
|View full text |Cite
|
Sign up to set email alerts
|

Comparison of Hypoxia-inducible Factor-1α Expression before and after Transcatheter Arterial Embolization in Rabbit VX2 Liver Tumors

Abstract: Purpose Hypoxia-inducible factor-1 alpha (HIF-1 α) expression has been linked with increased mortality and treatment failure in various cancers. The purpose of this study was to test the hypothesis that transcatheter arterial embolization (TAE) induces expression of HIF-1 α within the same rabbit VX2 liver tumor. Materials and Methods Seven VX2 tumors were grown in the livers of 5 New Zealand white rabbits. Ultrasound guided biopsies were taken before and 10 min after TAE from all tumors. Pre- and post- TAE … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
61
2

Year Published

2009
2009
2023
2023

Publication Types

Select...
7
3

Relationship

2
8

Authors

Journals

citations
Cited by 86 publications
(64 citation statements)
references
References 20 publications
0
61
2
Order By: Relevance
“…This increase in hypoxia directly up-regulates hypoxia-inducible factor1a (HIF-1a), which, in turn, increases expression of various proangiogenic proteins and receptors (including vascular endothelial growth factor and platelet-derived growth factor receptor) (7,8). Such events are advantageous to tumors, thereby limiting the potential for long-term disease control with TACE.…”
Section: Methodsmentioning
confidence: 99%
“…This increase in hypoxia directly up-regulates hypoxia-inducible factor1a (HIF-1a), which, in turn, increases expression of various proangiogenic proteins and receptors (including vascular endothelial growth factor and platelet-derived growth factor receptor) (7,8). Such events are advantageous to tumors, thereby limiting the potential for long-term disease control with TACE.…”
Section: Methodsmentioning
confidence: 99%
“…In a rabbit study, expression of hypoxia-inducible factor-1 alpha in nuclei of residual viable HCC cells after TAE was demonstrated (75), which regulates the release of multiple angiogenic factors such as VEGF, basic fibroblast growth factor (bFGF) and insulin-like growth factor (76). Plasma VEGF levels were shown to increase immediately after TACE with a peak value of 1 day after TACE (74,77).…”
Section: Combination Of Tace and Molecular Targeted Agentsmentioning
confidence: 99%
“…Survival curves characteristic of Yttrium microspheres treatment as an exclusive one are quite the same of chemoembolization 18 .…”
Section: Yttrium Microspheres Embolizationmentioning
confidence: 76%