Comparison of ibuprofen and piroxicam gel in the treatment of trauma pain: A randomized double-blind trial of geriatric population

Doğruyol, Sinem; Koçak, Abdullah Osman; Akbaş, İlker; Menekşe, Tuğba Sanalp; Gur, Sultan Tuna Akogal; Doğruyol, Talha; Çakır, Zeynep

doi:10.1016/j.ajem.2020.08.041

Cited by 6 publications

(4 citation statements)

References 17 publications

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“…A Cochrane systematic review on topical NSAIDs for acute musculoskeletal pain published in 2015 was included [ 15 ]. This review was updated with an additional 18 studies: 11 compared to placebo [ 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ], one compared to oral NSAIDs [ 60 ], three compared to topical NSAIDs [ 61 , 62 , 63 ], and three compared to other topical drugs [ 64 , 65 , 66 ].…”

Section: Resultsmentioning

confidence: 99%

Multidisciplinary Guidelines for the Rational Use of Topical Non-Steroidal Anti-Inflammatory Drugs for Musculoskeletal Pain (2022)

Shi

Shao

et al. 2023

JCM

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(1) Background: Topical non-steroidal anti-inflammatory drugs (NSAIDs) are one of the primary drugs for treating musculoskeletal pain. However, there are currently no evidence-based recommendations about drug selection, drug administration, drug interactions, and use in special populations or other pharmacology-related content of such medications. To this end, the Chinese Pharmaceutical Association Hospital Pharmacy Professional Committee developed multidisciplinary guidelines on using topical NSAIDs to treat musculoskeletal pain. (2) Methods: The guidelines development process followed the World Health Organization guideline development handbook, the GRADE methodology, and the statement of Reporting Items for Practice Guidelines in Healthcare. The guideline panel used the Delphi method to identify six clinical questions to be addressed in the guidelines. An independent systematic review team conducted a systematic search and integration of evidence. (3) Results: Based on the balance between the benefits and harms of an intervention, the quality of the evidence, patient preferences and values, and resource utilization, the guideline panel developed 11 recommendations and nine expert consensuses on using topical NSAIDs to treat acute and chronic musculoskeletal pain. (4) Conclusions: Based on the effectiveness and overall safety of topical NSAIDs, we recommend patients with musculoskeletal pain use topical NSAIDs and suggest high-risk patients use topical NSAIDs, such as those with other diseases or receiving other concurrent treatments. The evidenced-based guidelines on topical NSAIDs for musculoskeletal pain incorporated a pharmacist perspective. The guidelines have the potential to facilitate the rational use of topical NSAIDs. The guideline panel will monitor the relevant evidence and update the recommendations accordingly.

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Section: Resultsmentioning

confidence: 99%

Multidisciplinary Guidelines for the Rational Use of Topical Non-Steroidal Anti-Inflammatory Drugs for Musculoskeletal Pain (2022)

Shi

Shao

et al. 2023

JCM

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“…[ 1 , 7 , 11 ] To provide topical analgesia in acute musculoskeletal injuries, there are studies that report that the gel with both capsaicin and ibuprofen active ingredient is superior to piroxicam versus piroxicam with capsaicin and ibuprofen gel. [ 12 , 13 ] In a review, it was stated that topical agents such as diclofenac, ibuprofen, and ketoprofen showed similar effects to oral NSAIDs and were significantly effective in relieving pain. [ 14 ] In addition, there are no studies on the pain control of rib fractures with topically applied analgesic spray with the active ingredient etofenamate.…”

Section: Discussionmentioning

confidence: 99%

Placebo-controlled randomized double-blind comparison of the analgesic efficacy of lidocaine spray and etofenamate spray in pain control of rib fractures

Dönmez

2023

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: As far as we could detect, we could not find any study in literature on the analgesic efficacy of spray forms of lidocaine and etofenamate in rib fractures. In this study, our aim is to empirically compare the analgesic efficacy of etofenamate spray, lidocaine 10% spray and placebo spray in the management of pain secondary to trauma secondary to isolated rib fractures. METHODS: The study was designed according to a single-center, prospective, randomized, placebo-controlled double-blind study model. About 30 sealed envelopes were prepared for each of the 3 groups and 30 patients were included in each group. A total of 84 cases were included in the study (three groups: 27, 28, 29). RESULTS: Numeric rating scale (NRS) grades at admission and at 15-30-60-120 min were similar between the three groups (P>0.05). Analysis findings of NRS perception differences between the initial NRS level and the 15-30-60-120 th min NRS difference at the 0–120 th min showed more lidocaine spray organs, and it was not clearly perceived that these four parameters went between the 3 groups for the outline. CONCLUSION: The analgesic efficacy of lidocaine 10% spray, etofenamate spray, and placebo spray used together with standard dexketoprofen 50 mg intravenous treatment in the pain management of rib fractures were similar to each other and although there was a difference at the 120 th min, this difference was not statistically significant.

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“…The more repeated use of diclofenac and piroxicam may be due to their efficacy [ 59 , 60 ]. However, Dogruyol et al [ 61 ] showed greater efficacy of ibuprofen gel versus piroxicam gel in elderly subjects. All active ingredients were used in different proportions mixed with a conductive substance in gel form for administration.…”

Section: Discussionmentioning

confidence: 99%

Phonophoresis through Nonsteroidal Anti-Inflammatory Drugs for Knee Osteoarthritis Treatment: Systematic Review and Meta-Analysis

Martin-Vega,

Lucena-Anton,

Galán-Mercant

et al. 2022

Biomedicines

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Knee osteoarthritis (OA) is the most common joint disease. The administration of nonsteroidal anti-inflammatory drugs (NSAIDs) by phonophoresis is a therapeutic alternative to relieve pain in inflammatory pathologies. The main aim was to analyze the efficacy of the application of NSAIDs by phonophoresis in knee OA. A systematic review and meta-analysis of controlled clinical trials were performed between January and March 2021 in the following databases: Web of Science, Scopus, PubMed, Cinahl, SciELO, and PEDro. The PEDro scale was used to evaluate the level of evidence of the selected studies. The RevMan 5.4 statistical software was used to obtain the meta-analysis. Eight studies were included, of which five were included in the meta-analysis, involving 195 participants. The NSAIDs used through phonophoresis were ibuprofen, piroxicam, diclofenac sodium, diclofenac diethylammonium, ketoprofen, and methyl salicylate. The overall result for pain showed not-conclusive results, but a trend toward significance was found in favor of the phonophoresis group compared to the control group (standardized mean difference (SMD) = −0.92; 95% confidence interval: −1.87–0.02). Favorable results were obtained for physical function (SMD = −1.34; 95% CI: −2.00–0.68). Based on the selected studies, the application of NSAIDs by phonophoresis is effective in relieving the symptoms of knee OA. Future long-term studies are recommended.

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Comparison of ibuprofen and piroxicam gel in the treatment of trauma pain: A randomized double-blind trial of geriatric population

Cited by 6 publications

References 17 publications

Multidisciplinary Guidelines for the Rational Use of Topical Non-Steroidal Anti-Inflammatory Drugs for Musculoskeletal Pain (2022)

Multidisciplinary Guidelines for the Rational Use of Topical Non-Steroidal Anti-Inflammatory Drugs for Musculoskeletal Pain (2022)

Placebo-controlled randomized double-blind comparison of the analgesic efficacy of lidocaine spray and etofenamate spray in pain control of rib fractures

Phonophoresis through Nonsteroidal Anti-Inflammatory Drugs for Knee Osteoarthritis Treatment: Systematic Review and Meta-Analysis

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