Comparison of Imaging Biomarkers in the Alzheimer Disease Neuroimaging Initiative and the Mayo Clinic Study of Aging

Whitwell, Jennifer L.; Wiste, Heather J.; Weigand, Stephen D.; Rocca, Walter A.; Knopman, David S.; Roberts, Rosebud O.; Boeve, Bradley F.; Petersen, Ronald C.; Jack, Clifford R.

doi:10.1001/archneurol.2011.3029

Cited by 64 publications

(68 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…First, the ADNI cohort may not accurately reflect the population in terms of HAR in normal controls (Whitwell et al, 2012). ADNI exclusion criteria limit the range of values available for some variables we studied here.…”

Section: Discussionmentioning

confidence: 99%

Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment

Nosheny

Insel

Truran

et al. 2015

Neurobiology of Aging

View full text Add to dashboard Cite

The goal of this study was to identify factors contributing to hippocampal atrophy rate (HAR) in clinically-normal older adults (NC) and participants with mild cognitive impairment (MCI). Longitudinal HAR was measured on T1-weighted MRI, and the contribution of age, gender, ApoE ε4 status, intracranial volume, white matter lesions, and β-amyloid (Aβ) levels to HAR was determined using linear regression. Age-related effects of HAR were compared in Aβ positive (Aβ+) and Aβ negative (Aβ−) participants. Age and Aβ levels had independent effects on HAR in NC, while gender, ApoE ε4 status, and Aβ levels were associated with HAR in MCI. In multivariable models, Aβ levels were associated with HAR in NC; ApoE ε4 and Aβ levels were associated with HAR in MCI. In MCI, age was a stronger predictor of HAR in Aβ− versus Aβ+ participants. HAR was higher in Aβ+ participants, but the majority of HAR was due to factors other than Aβ status. Age-related effects on HAR did not differ between NC versus MCI participants with the same Aβ status. Therefore we conclude that even when accounting for other covariates, Aβ status, and not age, is a significant predictor of HAR; and that the majority of HAR is not accounted for by Aβ status in either NC or MCI.

show abstract

Section: Discussionmentioning

confidence: 99%

Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment

Nosheny

Insel

Truran

et al. 2015

Neurobiology of Aging

View full text Add to dashboard Cite

show abstract

“…Nonetheless, other measurements such as the Brain Atrophy and Lesion index have achieved AUC values of 70% or less [4]. Finally, the proposed cut-offs should be tested in population-based cohorts, since particularly the ADNI is a highly selected cohort and might not be completely representative of the general population [61,62]. …”

Section: Discussionmentioning

confidence: 99%

Measuring Global Brain Atrophy with the Brain Volume/Cerebrospinal Fluid Index: Normative Values, Cut-Offs and Clinical Associations

et al. 2015

View full text Add to dashboard Cite

Background: Global brain atrophy is present in normal aging and different neurodegenerative disorders such as Alzheimer's disease (AD) and is becoming widely used to monitor disease progression. Summary: The brain volume/cerebrospinal fluid index (BV/CSF index) is validated in this study as a measurement of global brain atrophy. We tested the ability of the BV/CSF index to detect global brain atrophy, investigated the influence of confounders, provided normative values and cut-offs for mild, moderate and severe brain atrophy, and studied associations with different outcome variables. A total of 1,009 individuals were included [324 healthy controls, 408 patients with mild cognitive impairment (MCI) and 277 patients with AD]. Magnetic resonance images were segmented using FreeSurfer, and the BV/CSF index was calculated and studied both cross-sectionally and longitudinally (1-year follow-up). Both AD patients and MCI patients who progressed to AD showed greater global brain atrophy compared to stable MCI patients and controls. Atrophy was associated with older age, larger intracranial volume, less education and presence of the ApoE ε4 allele. Significant correlations were found with clinical variables, CSF biomarkers and several cognitive tests. Key Messages: The BV/CSF index may be useful for staging individuals according to the degree of global brain atrophy, and for monitoring disease progression. It also shows potential for predicting clinical changes and for being used in the clinical routine.

show abstract

“…We used data from ADNI-GO and ADNI-2 cohorts, which represents a selected convenience sample including subjects with amnestic MCI, but also higher education and cognitive reserve. Compared to the ADNI cohort, the population-based sample in the Mayo Clinic Study of Aging (MCSA) [31] was older and less educated, and had lower MMSE scores and less frequent family history of AD. The rate of hippocampal volume decline was larger in ADNI subjects compared with MCSA, suggesting more advanced brain pathology in ADNI subjects [31].…”

Section: Discussionmentioning

confidence: 99%

“…Compared to the ADNI cohort, the population-based sample in the Mayo Clinic Study of Aging (MCSA) [31] was older and less educated, and had lower MMSE scores and less frequent family history of AD. The rate of hippocampal volume decline was larger in ADNI subjects compared with MCSA, suggesting more advanced brain pathology in ADNI subjects [31]. Additionally, analyzing early and late MCI subjects as 1 group might have affected our findings.…”

Section: Discussionmentioning

confidence: 99%

Florbetapir positron emission tomography and cerebrospinal fluid biomarkers

Hake

Trzepacz

Wang

et al. 2015

Alzheimer's & Dementia

View full text Add to dashboard Cite

Background We evaluated the relationship between florbetapir-F18 positron emission tomography (FBP PET) and cerebrospinal fluid (CSF) biomarkers. Methods Alzheimer’s Disease Neuroimaging Initiative (ADNI)-GO/2 healthy control (HC), mild cognitive impairment (MCI), and Alzheimer’s disease (AD) dementia subjects with clinical measures and CSF collected ±90 days of FBP PET data were analyzed using correlation and logistic regression. Results In HC and MCI subjects, FBP PET anterior and posterior cingulate and composite standard uptake value ratios correlated with CSF amyloid beta (Aβ1-42) and tau/Aβ1-42 ratios. Using logistic regression, Aβ1-42, total tau (t-tau), phosphorylated tau181P (p-tau), and FBP PET composite each differentiated HC versus AD. Aβ1-42 and t-tau distinguished MCI versus AD, without additional contribution by FBP PET. Total tau and p-tau added discriminative power to FBP PET when classifying HC versus AD. Conclusion Based on cross-sectional diagnostic groups, both amyloid and tau measures distinguish healthy from demented subjects. Longitudinal analyses are needed.

show abstract

Comparison of Imaging Biomarkers in the Alzheimer Disease Neuroimaging Initiative and the Mayo Clinic Study of Aging

Cited by 64 publications

References 45 publications

Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment

Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment

Measuring Global Brain Atrophy with the Brain Volume/Cerebrospinal Fluid Index: Normative Values, Cut-Offs and Clinical Associations

Florbetapir positron emission tomography and cerebrospinal fluid biomarkers

Contact Info

Product

Resources

About