Comparison of immunoglobulin free light chain (FLC), heavy chain/light chain (HLC) assays and immunofixation (IFE) in assessment of remission in multiple myeloma

Immunoglobulin Heavy Chain/Light Chain Pairs (Hlc, Hevylitetm) Assays for Diagnosing and Monitoring Monoclonal Gammopathies

“…PFS in this group of patients was 24 months vs. 12 months (p < 0.07) in patients with CR, VGPR and PR [18].…”

“…In all IgA MM patients concordance of 3 tests (IFE negative, HLC ratio normal, FLC ratio normal) was found. Discrepancy between IFE and HLC and FLC results (IFE positive, HLC ratio normal, FLC ratio normal) was found in patients with IgG MM [18].…”

Calorimetric features of IgM gammopathies. Implication for patient’s diagnosis and monitoring

“…Clinically applied assay ("IgM Hevylite immunoassay") for monoclonality identification, prognosis prediction and monitoring response to treatment in multiple myeloma has recently been developed [10] and justified as a reliable progression marker in the monitoring of monoclonal gammopathies but not suited for diagnostics [14][15][16][17][18][19][20][21]. It relies on antibody binding to the epitopes spanning the junctional regions between either k or l light chain and their respective heavy chain partners.…”