Comparison of immunotoxic effects induced by the extracts from methanol and gasoline engine exhausts in vitro

Che, Wangjun; Liu, Guiming; Qiu, Hong; Zhang, Hao; Ran, Yun; Xianggui, Zeng; Wen, Weihua; Shu, Yongqian

doi:10.1016/j.tiv.2010.03.008

Cited by 9 publications

(3 citation statements)

References 33 publications

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“…Engine exhausts are known to cause adverse health effects [ 1 , 2 ]. Toxicities associated with the exposure of engine exhausts include carcinogenicity, mutagenicity and immunotoxicity [ 3 – 5 ]. Toxicity assessments of engine exhausts is essential for developing safe alternative fuels with lower toxicity [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of informative features for predicting proinflammatory potentials of engine exhausts

Lin

Jhang

et al. 2017

BioMed Eng OnLine

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BackgroundThe immunotoxicity of engine exhausts is of high concern to human health due to the increasing prevalence of immune-related diseases. However, the evaluation of immunotoxicity of engine exhausts is currently based on expensive and time-consuming experiments. It is desirable to develop efficient methods for immunotoxicity assessment.MethodsTo accelerate the development of safe alternative fuels, this study proposed a computational method for identifying informative features for predicting proinflammatory potentials of engine exhausts. A principal component regression (PCR) algorithm was applied to develop prediction models. The informative features were identified by a sequential backward feature elimination (SBFE) algorithm.ResultsA total of 19 informative chemical and biological features were successfully identified by SBFE algorithm. The informative features were utilized to develop a computational method named FS-CBM for predicting proinflammatory potentials of engine exhausts. FS-CBM model achieved a high performance with correlation coefficient values of 0.997 and 0.943 obtained from training and independent test sets, respectively.ConclusionsThe FS-CBM model was developed for predicting proinflammatory potentials of engine exhausts with a large improvement on prediction performance compared with our previous CBM model. The proposed method could be further applied to construct models for bioactivities of mixtures.

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Section: Introductionmentioning

confidence: 99%

Identification of informative features for predicting proinflammatory potentials of engine exhausts

Lin

Jhang

et al. 2017

BioMed Eng OnLine

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“…Vehicle emissions have been shown to significantly inhibit endocrine [ 1 , 2 , 3 ], reproductive [ 4 , 5 , 6 , 7 ], and immune system [ 8 , 9 ] function through a variety of different mechanisms. Diesel exhaust particles confer toxicity in human neutrophil granulocytes, rat alveolar macrophages, and murine RAW 264.7 macrophages [ 10 , 11 ], and suppress cytokine release [ 12 ], significantly diminishing immune function [ 13 , 14 ], while gasoline exhaust particles have also been shown to inhibit T-cell proliferation [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Walnut Polyphenol Extract Attenuates Immunotoxicity Induced by 4-Pentylphenol and 3-methyl-4-nitrophenol in Murine Splenic Lymphocyte

Yang

Han

et al. 2016

Nutrients

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4-pentylphenol (PP) and 3-methyl-4-nitrophenol (PNMC), two important components of vehicle emissions, have been shown to confer toxicity in splenocytes. Certain natural products, such as those derived from walnuts, exhibit a range of antioxidative, antitumor, and anti-inflammatory properties. Here, we investigated the effects of walnut polyphenol extract (WPE) on immunotoxicity induced by PP and PNMC in murine splenic lymphocytes. Treatment with WPE was shown to significantly enhance proliferation of splenocytes exposed to PP or PNMC, characterized by increases in the percentages of splenic T lymphocytes (CD3+ T cells) and T cell subsets (CD4+ and CD8+ T cells), as well as the production of T cell-related cytokines and granzymes (interleukin-2, interleukin-4, and granzyme-B) in cells exposed to PP or PNMC. These effects were associated with a decrease in oxidative stress, as evidenced by changes in OH, SOD, GSH-Px, and MDA levels. The total phenolic content of WPE was 34,800 ± 200 mg gallic acid equivalents/100 g, consisting of at least 16 unique phenols, including ellagitannins, quercetin, valoneic acid dilactone, and gallic acid. Taken together, these results suggest that walnut polyphenols significantly attenuated PP and PNMC-mediated immunotoxicity and improved immune function by inhibiting oxidative stress.

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“…However, for the immunotoxicity of engine exhausts that have drawn increasing attentions [15], there is currently no well-established method for the evaluation of immunotoxicity potentials. Instead of conducting experiments for immunotoxicity assessment that are both labor-intensive and expensive, it is desirable to develop a computational method for predicting immunotoxicity of engine exhausts.…”

Section: Introductionmentioning

confidence: 99%

Prediction of Proinflammatory Potentials of Engine Exhausts by Integrating Chemical and Biological Features

Lin

Jhang

et al. 2016

Bioinformatics and Biomedical Engineering

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Abstract. The increasing prevalence of immune-related diseases has raised concerns about immunotoxicity of engine exhausts. The evaluation of immunotoxicity associated with engine exhausts has relied on expensive and timeconsuming experiments. In this study, a computational method named CBM was developed for predicting proinflammatory potentials of engine exhausts using chemical and biological data which are routinely analyzed for toxicity evaluation. The CBM model, based on a principal component regression algorithm, performs well with high correlation coefficient values of 0.972 and 0.849 obtained from training and independent test sets, respectively. In contrast, chemical or biological features alone showed poor correlation with the toxicity. The model indicates the importance of the utilization of both chemical and biological features for developing an effective model. The proposed method could be further developed and applied to predict bioactivities of mixtures.

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Comparison of immunotoxic effects induced by the extracts from methanol and gasoline engine exhausts in vitro

Cited by 9 publications

References 33 publications

Identification of informative features for predicting proinflammatory potentials of engine exhausts

Identification of informative features for predicting proinflammatory potentials of engine exhausts

Walnut Polyphenol Extract Attenuates Immunotoxicity Induced by 4-Pentylphenol and 3-methyl-4-nitrophenol in Murine Splenic Lymphocyte

Prediction of Proinflammatory Potentials of Engine Exhausts by Integrating Chemical and Biological Features

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