Comparison of implosion core metrics: A 10 ps dilation X-ray imager vs a 100 ps gated microchannel plate

Nagel, S. R.; Benedetti, L. R.; Bradley, D. K.; Hilsabeck, T.; Izumi, N.; Khan, S. F.; Kyrala, G. A.; Ma, T.; Pak, A.

doi:10.1063/1.4959917

Cited by 35 publications

(5 citation statements)

References 16 publications

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“…There are two forms which are generated by mRNA processing: one is α CGRP which is predominant in central peripheral system as well as in several endocrine tissues, and the other is β CGRP which differs in single amino acid sequence from α CGRP and is located in brain, sensory ganglia, and thyroid gland. The α CGRP efficiently plays a role in response to painful provocations, cardiovascular homeostasis, digestive behavior, and mineral metabolism, while β CGRP roles as neuroactive regulators and hormones and the importance of these peptides in normal brain development . Other members like adrenomedullin, amylin, calcitonin, intermedin, and calcitonin receptor‐stimulating peptide have same homology with the CGRP …”

Section: Biology Of Calcitonin Gene‐related Peptide (Cgrp)mentioning

confidence: 99%

Calcitonin gene‐related peptide (CGRP): A novel target for Alzheimer's disease

et al. 2017

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Alzheimer's disease (AD) is leading cause of death among older characterized by neurofibrillary tangles, oxidative stress, progressive neuronal deficits, and increased levels of amyloid-β (Aβ) peptides. Cholinergic treatment could be the best suitable physiological therapy for AD. Calcitonin gene-related peptide (CGRP) is a thirty-seven-amino acid regulatory neuropeptide resulting from different merging of the CGRP gene, which also includes adrenomedullin, amylin, calcitonin, intermedin, and calcitonin receptor-stimulating peptide. It is a proof for a CGRP receptor within nucleus accumbens of brain that is different from either the CGRP or CGRP receptor in which it demonstrates similar high-affinity binding for salmon calcitonin, CGRP, and amylin, a possession which is not shared by any extra CGRP receptors. Binding of CGRP to its receptor increases activated cAMP-dependent pkA and PI3 kinase, resulting in N-terminal fragments that are shown to exert complex inhibitory as well facilitator actions on nAChRs. Fragments such as CGRP1-4, CGRP1-5, and CGRP1-6 rapidly as well as reversibly improve agonist sensitivity of nAChRs without straight stimulating those receptors and produce the Ca -induced intracellular Ca mobilization. Renin-angiotensin-aldosterone system (RAAS)-activated angiotensin-type (AT4) receptor is also beneficial in AD. It has been suggested that exogenous administration of CGRP inhibits infiltration of macrophages and expression of various inflammatory mediators such as NFkB, IL-1b, TNF-α, iNOS, matrix metalloproteinase (MMP)-9, and cell adhesion molecules like intercellular adhesion molecule (ICAM)-1 which attenuates consequence of inflammation in AD. Donepezil, a ChEI, inhibits acetylcholinesterase and produces angiogenesis and neurogenesis, in the dentate gyrus of the hippocampus of WT mice after donepezil administration. However, none of the results discovered in CGRP-knockout mice and WT mice exposed to practical denervation. Therefore, selective agonists of CGRP receptors may become the potential candidates for treatment of AD.

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Section: Biology Of Calcitonin Gene‐related Peptide (Cgrp)mentioning

confidence: 99%

Calcitonin gene‐related peptide (CGRP): A novel target for Alzheimer's disease

et al. 2017

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“…Since only time-integrated measurement or time-resolved measurement with a resolution of over 70 ps is practical in our experiments at present, the effect of temporal resolution is not discussed here, but will probably further affect the shape according to the reported results [25] and will be of interest in In the single-mode case of cryogenic implosion by a 100 kJ class laser drive, the capsule is made of DT gas, DT ice, and a plastic ablator from inside to outside. At the bangtime shown in figure 2(c), the DT hot spot with a temperature of over 2 keV is surrounded by a much denser DT fuel with density up to 100 g cm −3 and the remaining plastic ablator, clear interface perturbation can be inferred.…”

Section: Forward-calculation Methods and Shape-metrics Analysismentioning

confidence: 99%

Study of the asymmetry of hot-spot self-emission imaging of inertial confinement fusion implosion driven by high-power laser facilities

Dong¹,

Kang²,

Jiang³

et al. 2020

Plasma Sci. Technol.

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Implosion asymmetry is a crucial problem quenching ignition in the field of inertial confinement fusion. A forward-calculation method based on 1D and 2D hydrodynamic simulations has been developed to generate and study the x-ray images of hot-spot self-emission, indicating asymmetry integrated over the entire drive pulse. It is shown that the x-ray imaging photon energy should be higher to avoid the influence of the remaining shell. The contour level (percentage of the maximum emission intensity) and spatial resolution should be as low as possible, optimally less than 20% and 3 mm, for characterization of higher-mode signatures such as P 8 -P 12 by x-ray self-emission images. On the contrary, signatures of lower-mode such as P 2 remain clear at all contour levels and spatial resolutions. These key results can help determine the optimal diagnostics, laser, and target parameters for implosion experiments. Recent typical hot-spot asymmetry measurements and applications on the Shenguang 100 kJ class laser facility are also reported.

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“…A grid of 10 × 10 points was placed on the nanoparticle surface, and a force indentation curve was recorded at each point at a force trigger of 5 nN. At each indentation position, the Young's modulus was determined by fitting a Hertz model (cone indenter) to the approach curve using AtomicJ [46]. One hundred different points on each of eight individual PBSe-GSK3787 particles and seven PBSe-NDL particles were used for measurements.…”

Section: Atomic Force Microscopymentioning

confidence: 99%

GSK3787-Loaded Poly(Ester Amide) Particles for Intra-Articular Drug Delivery

et al. 2020

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Osteoarthritis (OA) is a debilitating joint disorder affecting more than 240 million people. There is no disease modifying therapeutic, and drugs that are used to alleviate OA symptoms result in side effects. Recent research indicates that inhibition of peroxisome proliferator-activated receptor δ (PPARδ) in cartilage may attenuate the development or progression of OA. PPARδ antagonists such as GSK3787 exist, but would benefit from delivery to joints to avoid side effects. Described here is the loading of GSK3787 into poly(ester amide) (PEA) particles. The particles contained 8 wt.% drug and had mean diameters of about 600 nm. Differential scanning calorimetry indicated the drug was in crystalline domains in the particles. Atomic force microscopy was used to measure the Young’s moduli of individual particles as 2.8 MPa. In vitro drug release studies showed 11% GSK3787 was released over 30 days. Studies in immature murine articular cartilage (IMAC) cells indicated low toxicity from the drug, empty particles, and drug-loaded particles and that the particles were not taken up by the cells. Ex vivo studies on murine joints showed that the particles could be injected into the joint space and resided there for at least 7 days. Overall, these results indicate that GSK3787-loaded PEA particles warrant further investigation as a delivery system for potential OA therapy.

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Comparison of implosion core metrics: A 10 ps dilation X-ray imager vs a 100 ps gated microchannel plate

Cited by 35 publications

References 16 publications

Calcitonin gene‐related peptide (CGRP): A novel target for Alzheimer's disease

Calcitonin gene‐related peptide (CGRP): A novel target for Alzheimer's disease

Study of the asymmetry of hot-spot self-emission imaging of inertial confinement fusion implosion driven by high-power laser facilities

GSK3787-Loaded Poly(Ester Amide) Particles for Intra-Articular Drug Delivery

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