Comparison of In-Hospital Mortality and Clinical Outcomes Between Patients Aged More Than and Less Than 80 Years Undergoing Transcatheter Aortic Valve Replacement

Murthi, Mukunthan; Velagapudi, Sujitha; Sharma, Bharosa; Ezegwu, Olisa; Akuna, Emmanuel; Park, Dae Yong; Atluri, Ramtej; Vardar, Ufuk

doi:10.7759/cureus.24534

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Vendrik and co-workers demonstrated comparable mortality in individuals up to five years old, regardless of age [34]. On the other hand, patients who were >90 years old and >80 years old, respectively, saw an increase in in-hospital mortality, according to other papers [35,36]. In their multicenter prospective Spanish TAVI registry, Cepas-Guillén and colleagues reported their results comparing nonagenarian patients with severe aortic stenosis with patients aged 75 to 89 years old who had the same treatment [33].…”

Section: Discussionmentioning

confidence: 92%

Risk of Bleeding in Elderly Patients Undergoing Transcatheter Aortic Valve Implantation or Surgical Aortic Valve Replacement

Jiritano,

Serraino,

Sorrentino

et al. 2024

Prosthesis

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Background: Bleeding complications are strong predictors of mortality and major morbidity in elderly patients undergoing surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVI). Despite the high prevalence of frailty in this population, little is known about its effects on bleeding risk. Methods: We conducted a retrospective observational study of 502 patients undergoing isolated SAVR or TAVI between January 2015 and February 2022. The occurrence of blood products transfusions and MACEs were the primary endpoints. In-hospital mortality was the secondary endpoint. Results: The Elderly group (age < 80 years old) included 475 subjects, whereas the Very Elderly group (age ≥ 80 years old) included 127 patients. The need for blood product transfusion was similar among the two groups, regardless of the type of procedure. MACEs occurred similarly between groups [SAVR: Elderly group: 7.9% vs. Very Elderly group: 8.6%, p = 0.864; TAVI: Elderly group: 5.5% vs. Very Elderly group: 8.7%, p = 0.378]. The was no difference in in-hospital mortality rate in patients submitted to TAVI, whereas very elderly patients had higher mortality rate compared to the elderly patients submitted to SAVR [SAVR: Elderly group: 0% vs. Very Elderly group: 2.8%, p = 0.024; TAVI: Elderly group: 4,8% vs. Very Elderly group: 8%, p = 0.389]. Conclusions: Age alone should not be considered as a predictive factor for post-operative adverse events or in-hospital mortality in elderly patients with severe symptomatic AS.

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Section: Discussionmentioning

confidence: 92%

Risk of Bleeding in Elderly Patients Undergoing Transcatheter Aortic Valve Implantation or Surgical Aortic Valve Replacement

Jiritano,

Serraino,

Sorrentino

et al. 2024

Prosthesis

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Age is no factor in TAVI

Adrichem

Mieghem

2022

Neth Heart J

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Racial Disparities in Patients With COVID-19 Infection: A National Inpatient Sample Analysis

Vardar¹,

Ilelaboye²,

Murthi³

et al. 2023

Cureus

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IntroductionEvidence suggests the COVID-19 (coronavirus disease 2019) pandemic highlighted well-known healthcare disparities. This study investigated racial disparities in patients with COVID-19-related hospitalizations utilizing the US (United States) National Inpatient Sample (NIS). MethodologyThis was a retrospective study conducted utilizing the NIS 2020 database. The NIS was searched for hospitalization of adult patients with COVID-19 infection as a principal diagnosis using ICD-10 (International Classification of Diseases, Tenth Revision) codes. We divided the NIS into four major racial/ethnic groups: White, Black, Hispanic, and others. The primary outcome was inpatient mortality, and the secondary outcomes were the mean length of stay, mean total hospital charges, development of sepsis, septic shock, use of vasopressors, acute respiratory failure, acute respiratory distress syndrome, acute kidney failure, acute myocardial infarction, cardiac arrest, deep vein thrombosis, pulmonary embolism, cerebrovascular accident, and need for mechanical ventilation. ResultsCompared to White patients, Hispanic patients had higher adjusted inpatient mortality odds (aOR [adjusted odds ratio]: 1.25, 95% CI 1.19-1.33, p<0.001); however, Black patients had similar adjusted mortality odds (aOR: 0.96, 95% CI 0.91-1.01, p=0.212). Black patients and Hispanic patients had a higher mean length of

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Comparison of In-Hospital Mortality and Clinical Outcomes Between Patients Aged More Than and Less Than 80 Years Undergoing Transcatheter Aortic Valve Replacement

Cited by 3 publications

References 28 publications

Risk of Bleeding in Elderly Patients Undergoing Transcatheter Aortic Valve Implantation or Surgical Aortic Valve Replacement

Risk of Bleeding in Elderly Patients Undergoing Transcatheter Aortic Valve Implantation or Surgical Aortic Valve Replacement

Age is no factor in TAVI

Racial Disparities in Patients With COVID-19 Infection: A National Inpatient Sample Analysis

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