Comparison of In-Hospital Mortality from Acute Myocardial Infarction in HIV Sero-Positive Versus Sero-Negative Individuals

Pearce, Daniel; Ani, Chizobam; Espinosa-Silva, Yaminah; Clark, Ryan; Fatima, Khuteja; Rahman, Munira; Diebolt, Erik; Ovbiagele, Bruce

doi:10.1016/j.amjcard.2012.05.045

Cited by 44 publications

(39 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This approach was taken to specifically focus on patients who presented with acute myocardial ischemia and not those with AMI secondary to surgery, hypotension, or other events after admission. 20 In cases of multiple admissions of a patient for an AMI, only the first stay was included in our final analysis to avoid counting the same patient twice. MI was defined by an increase in serum troponin I (higher than the upper limit of the hospital's normal range) and clinical symptoms of ischemia or characteristic ECG signs.…”

Section: Selection Of Patientsmentioning

confidence: 99%

Outcomes After Acute Myocardial Infarction in HIV-Infected Patients

et al. 2013

View full text Add to dashboard Cite

Background— We aimed to assess in-hospital case fatality and 1-year prognosis in HIV-infected patients with acute myocardial infarction. Methods and Results— From the PMSI (Program de Medicalisation des Systèmes d’informatique) database, data from 277 303 consecutive acute myocardial infarction patients hospitalized from January 1, 2005, to December 31, 2009, were analyzed. Surviving patients were followed up for 1 year after discharge. HIV-infected patients were compared with uninfected patients. Among the cohort, HIV-infected patients (n=608) accounted for 0.22%. All-cause hospital and 1-year mortality rates were lower in the HIV-infected group than in uninfected patients (3.1% versus 8.1% [ P <0.001] and 1.4% versus 5.5% [ P <0.001], respectively). From the database, we then analyzed a cohort derived from a matching procedure, with 1 HIV patient matched with 2 patients without HIV, based on age and sex (n=1824). Ischemic cardiomyopathy was more frequent in the HIV group (7.6% versus 4.2%, P =0.003). Hospitalization and 1-year mortality rates were similar in the 2 groups (3.1% versus 2.1% [ P =0.168] and 1.4% versus 1.7% [ P =0.642], respectively). However, at 12 months, hospitalizations for episodes of heart failure were significantly more frequent in HIV-infected than in uninfected patients (3.3% versus 1.4%, respectively; P =0.020). HIV infection, diabetes mellitus, history of ischemic cardiomyopathy, and undergoing percutaneous coronary intervention were associated in univariate analysis with occurrence of heart failure. By multivariable analysis, HIV infection (odds ratio 2.82, 95% confidence interval 1.32–6.01), diabetes mellitus, and undergoing percutaneous coronary intervention remained independent predictors of heart failure. Conclusions— The present study demonstrates that after acute myocardial infarction, HIV status influences long-term risk, although the short-term risk in HIV patients is comparable to that in uninfected patients.

show abstract

Section: Selection Of Patientsmentioning

confidence: 99%

Outcomes After Acute Myocardial Infarction in HIV-Infected Patients

et al. 2013

View full text Add to dashboard Cite

show abstract

“…(106**, 107) Other data on medical management and outcomes following acute myocardial infarction show that HIV+ people received significantly fewer cardiovascular procedures and/or therapeutics (e.g., thrombolytic and anticoagulant agents, coronary arteriography, cardiac catheterization, CABG). (108**) In addition, the risk of in-hospital mortality following AMI was 38% higher among HIV+ adults. In spite of this, HIV+ people are likely to incur greater direct medical costs for non-infectious comorbidities (including CVD) compared to uninfected people.…”

Section: Environmental Mechanisms Of Cvd In Hivmentioning

confidence: 99%

Cardiovascular disease risk in an aging HIV population

So‐Armah

Freiberg

2014

Current Opinion in HIV and AIDS

View full text Add to dashboard Cite

Purpose of review The objective of this review is to 1) appraise recently published literature that describes the relationship between HIV, biologic and environmental risk factors, and CVD risk with particular emphasis on the aging HIV population and 2) to demonstrate that these biologic and environmental factors may interact to increase the risk of CVD in the HIV population. Recent findings The mechanisms linking HIV and CVD are multi-factorial and encompass biological and “environmental” modalities including multi-morbid conditions that co-occur with HIV, immunologic alterations associated with HIV, polypharmacy (which affects adherence and increases likelihood of adverse drug-drug interactions) and healthcare disparities in CVD risk reduction by HIV status. Summary Data regarding optimal treatment strategies that balance immunological restoration and CVD risk reduction are needed.

show abstract

“…While research suggests that hospitalizations among PLWH are largely manageable (Betz et al, 2005), longer duration of hospital stays are more common among this population compared to their uninfected counterparts (Akgun et al, 2013; Pearce et al, 2012). Prolonged hospital stays are also commonly associated with hospital-acquired infections among those already affected by infectious diseases (Dulworth & Pyenson, 2004; Mohammed, Furuya, & Larson, 2014).…”

Section: Introductionmentioning

confidence: 99%

The impact of HIV diagnosis on length of hospital stay in New York City, NY, USA

et al. 2018

View full text Add to dashboard Cite

While hospitalizations among people living with human immunodeficiency virus (PLWH) have been elevated in the past compared to their uninfected counterparts, the introduction of antiretroviral therapy (ART) has resulted in great strides in controlling symptomatic infection. However, research largely overlooks important differences among HIV-infected individuals, primarily PLWH who are symptomatic versus those who are asymptomatic. We conducted a retrospective study assessing the length of hospital stay among 717,237 admissions from three hospitals in the New York City area. Using zero-truncated negative binomial regression we documented trends in length of hospital stay among individuals who are HIV positive (with symptoms versus those without symptoms) compared to HIV-negative patients over nine consecutive years, from 2006 to 2014. Approximately 0.85% of the admissions were infected with asymptomatic HIV (n = 6,131), while 1.43% of admissions were infected with symptomatic HIV (n = 10,271). The length of stay (LOS) among symptomatic HIV-infected admissions was 32.0% (95% CI: 29.7%–34.2%) longer than LOS in the general admissions. The mean LOS dropped about 1.5% (95% CI: 1.5%– 1.6%) per year in the study sample. The LOS in inpatients with asymptomatic HIV had the same LOS as the general inpatient population. Our findings highlight the need for comprehensive strategies to reduce length of hospitalization among HIV-infected individuals.

show abstract

Comparison of In-Hospital Mortality from Acute Myocardial Infarction in HIV Sero-Positive Versus Sero-Negative Individuals

Cited by 44 publications

References 24 publications

Outcomes After Acute Myocardial Infarction in HIV-Infected Patients

Outcomes After Acute Myocardial Infarction in HIV-Infected Patients

Cardiovascular disease risk in an aging HIV population

The impact of HIV diagnosis on length of hospital stay in New York City, NY, USA

Contact Info

Product

Resources

About