Comparison of in vitro antibacterial activity of streptomycin-diclofenac loaded composite biomaterial dressings with commercial silver based antimicrobial wound dressings

Pawar, Harshavardhan; Debrah, Philip; Boateng, Joshua

doi:10.1016/j.ijbiomac.2018.10.023

Cited by 18 publications

(5 citation statements)

References 38 publications

(58 reference statements)

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“…When placed on growth media, films absorb water, undergo swelling, and release loaded antibiotics, similar to when films are placed on infected wounds. Therefore, the higher antibacterial activity of AX-GL films indicates the ability of these films to maintain the effective concentration of GM in the wound environment for a longer period of time [41]. These results suggest that the antibacterial performance of the GM-loaded AX-GL…”

Section: Antibacterial Activities Of Ax-gl Filmsmentioning

confidence: 84%

Antibiotic-Loaded Psyllium Husk Hemicellulose and Gelatin-Based Polymeric Films for Wound Dressing Application

Ahmad

Alruwaili

et al. 2021

Pharmaceutics

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Wound infections are one of the major reasons for the delay in the healing of chronic wounds and can be overcome by developing effective wound dressings capable of absorbing exudate, providing local antibiotic release, and improving patient comfort. Arabinoxylan (AX) is a major hemicellulose present in psyllium seed husk (PSH) and exhibits promising characteristics for developing film dressings. Herein, AX-gelatin (GL) films were prepared by blending AX, gelatin (GL), glycerol, and gentamicin (antibiotic). Initially, the optimal quantities of AX, GL, and glycerol for preparing transparent, bubble-free, smooth, and foldable AX-GL films were found. Physiochemical, thermal, morphological, drug release, and antibacterial characteristics of the AX-GL films were evaluated to investigate their suitability as wound dressings. The findings suggested that the mechanical, water vapor transmission, morphological, and expansion characteristics of the optimized AX-GL films were within the required range for wound dressing. The results of Fourier-transform infrared (FTIR) analyses suggested chemical compatibility among the ingredients of the films. In in vitro drug release and antibacterial activity experiments, gentamicin (GM)-loaded AX-GL films released approximately 89% of the GM in 24 h and exhibited better antibacterial activity than standard GM solution. These results suggest that AX-GL films could serve as a promising dressing to protect against wound infections.

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Section: Antibacterial Activities Of Ax-gl Filmsmentioning

confidence: 84%

Antibiotic-Loaded Psyllium Husk Hemicellulose and Gelatin-Based Polymeric Films for Wound Dressing Application

Ahmad

Alruwaili

et al. 2021

Pharmaceutics

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“…In the present study, the replacement of the Eagle's minimum essential medium every two days and the supplementation with penicillin and streptomycin also increased the survival time of N. buttnerae for up to 42 days when maintained at 24 °C. The antibiotics penicillin and streptomycin are frequently used in the control of bacterial growth (Pawar et al, 2019;Ulkhaq et al, 2020). The combination of penicillin and streptomycin is promising, since penicillin has shown greater efficacy against gram-positive bacteria and streptomycin is more active against aerobic gramnegative bacteria (Madigan et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

In vitro culture and morphology of Neoechinorhynchus buttnerae (Eoacanthocephala: Neoechinorhynchidae) collected from the intestine of tambaqui (Colossoma macropomum) farmed in the Brazilian Amazon

Oliveira,

Majolo,

Sebastião

et al. 2023

Braz. J. Biol.

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The tambaqui (Colossoma macropomum) is a species of great economic importance for fish farming in the Brazilian Amazon, and acanthocephaliasis caused by Neoechinorhynchus buttnerae (Golvan 1956) represents an obstacle to its production due to it causing severe morphological damage to the intestinal mucosa, thus impairing the absorption of nutrients and causing weight loss in the fish. Therefore, the establishment of in vitro protocols for evaluation of anthelmintic drugs is the first step to development of effective measures for in vivo control of this endoparasite. The present study evaluated the in vitro survival of N. buttnerae maintained in Eagle’s minimum essential medium under different culture conditions. Three assays were carried out to evaluate whether temperature, supplementation with the antibiotics penicillin and streptomycin, and culture medium replacement or no replacement would influence the motility and morphology of the acanthocephalans. The results of the Kaplan-Meier analysis indicated that the use of culture in minimum essential medium together with penicillin and streptomycin prolonged the parasite’s survival when kept at temperatures of 24 °C or 28 °C. We describe herein for first time an alternative protocol that is ideal for the in vitro culture of N. buttnerae. As such, this protocol ensures greater reliability in further in vitro studies with N. buttnerae.

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“…Alginate dressings are obtained from soft, nonwoven alginic acid fibers, a cellulose-like polysaccharide derived from seaweed, coated in calcium and sodium salts [63]. They have the capacity to form gels at the time of contact with wound exudates, which permits easier dressing removal [145]. Alginate dressings are indicated for moderate to heavily exuding wounds.…”

Section: Alginate Dressingsmentioning

confidence: 99%

Nanomaterials for Wound Dressings: An Up-to-Date Overview

2020

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As wound healing continues to be a challenge for the medical field, wound management has become an essential factor for healthcare systems. Nanotechnology is a domain that could provide different new approaches concerning regenerative medicine. It is worth mentioning the importance of nanoparticles, which, when embedded in biomaterials, can induce specific properties that make them of interest in applications as materials for wound dressings. In the last years, nano research has taken steps to develop molecular engineering strategies for different self-assembling biocompatible nanoparticles. It is well-known that nanomaterials can improve burn treatment and also the delayed wound healing process. In this review, the first-line of bioactive nanomaterials-based dressing categories frequently applied in clinical practice, including semi-permeable films, semipermeable foam dressings, hydrogel dressings, hydrocolloid dressings, alginate dressings, non-adherent contact layer dressings, and multilayer dressings will be discussed. Additionally, this review will highlight the lack of high-quality evidence and the necessity for future advanced trials because current wound healing therapies generally fail to provide an excellent clinical outcome, either structurally or functionally. The use of nanomaterials in wound management represents a unique tool that can be specifically designed to closely reflect the underlying physiological processes in tissue repair.

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Comparison of in vitro antibacterial activity of streptomycin-diclofenac loaded composite biomaterial dressings with commercial silver based antimicrobial wound dressings

Cited by 18 publications

References 38 publications

Antibiotic-Loaded Psyllium Husk Hemicellulose and Gelatin-Based Polymeric Films for Wound Dressing Application

Antibiotic-Loaded Psyllium Husk Hemicellulose and Gelatin-Based Polymeric Films for Wound Dressing Application

In vitro culture and morphology of Neoechinorhynchus buttnerae (Eoacanthocephala: Neoechinorhynchidae) collected from the intestine of tambaqui (Colossoma macropomum) farmed in the Brazilian Amazon

Nanomaterials for Wound Dressings: An Up-to-Date Overview

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