Comparison of in vitro antioxidant, antimicrobial and anticancer activity of Murraya koenigii leaf and stem extracts in ovarian cancer cells

Abstract

Ovarian cancer (OC) is the most lethal gynecological cancer, due to its diagnosis at later stages III and IV. Drug resistance developed at later stages further decreases survival rates to 30% in ovarian cancer patients. Natural compounds isolated from plant extract can have promising potential in cancer treatment due to their minimal side effects. Murraya koenigii (MK) leaves commonly used in Indian cuisines, are known to have antimicrobial, antifungal, and antioxidant activity. However, very few studies show the effect of MK extracts on ovarian cancer. This study shows the comparison of phytochemical content, antioxidant, antimicrobial and cytotoxic activities of methanol, aqueous and toluene extracts of MK leaves and stems. These extracts showed anticancer activity on the ovarian teratocarcinoma cell line - PA1 via apoptosis and antiangiogenic effect on healthy chick embryos.