Comparison of in vitro fertilization cycles in couples with human immunodeficiency virus type 1 infection versus noninfected couples through a retrospective matched case-control study

Vianna, Caroline Aimone; Dupont, Charlotte; Selleret, Lise; Canestri, Ana; Lévy, Rachel; Hamid, Rahaf Haj

doi:10.1016/j.xfre.2021.04.008

Cited by 2 publications

(1 citation statement)

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“…Washing of semen is beneficial in intrauterine insemination (IUI), IVF, and intracytoplasmic sperm injection (ICSI) procedures. A total of 85 HIV-discordant couples underwent reproductive screening, out of which 29 uninfected female partners did not contract HIV in the first study in 1989 that offered washing of semen to HIV-serodifferent partners using intrauterine insemination (IUI) [6].…”

Section: Introductionmentioning

confidence: 99%

A Successful Pregnancy Outcome in a Human Immunodeficiency Virus Serodiscordant Couple in a Single Cycle of In Vitro Fertilization/Intracytoplasmic Sperm Injection: A Case Report

Wadkar¹,

More²

2022

Cureus

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Human immunodeficiency virus (HIV) is a virus that affects the immune system and attacks immune cells called CD4 while also raising the risk and severity of other infections and diseases. Despite the fact that HIV can infect persons of any age, the majority of infected people are those of reproductive age between 15 and 44 years. Many women and men with HIV desire children. Plenty of HIV-positive adults worldwide wish to have a child. As a result, reproductive desires have emerged as clinically significant in patients with HIV/acquired immunodeficiency syndrome (AIDS). We present a case of a 35-year-old male who is HIV-1 seropositive and his 32-year-old healthy wife who is seronegative who visited an in vitro fertilization (IVF) clinic. The couple was married for four years, facing primary infertility, and had a history of failure of three successive intrauterine insemination (IUI) cycles. The couple abstained from physical contact when the husband was discovered HIV positive. The couple wanted to have their own biological, completely healthy child. The male was undertaking highly active antiretroviral therapy (HAART). On the performance of the semen analysis test, the male was discovered to have oligospermia. The blood test of the female revealed that her anti-Mullerian hormone (AMH) level was raised, and ultrasound indicated polycystic ovarian syndrome (PCOS). The couple was suggested IVF/intracytoplasmic sperm injection (ICSI) treatment due to failure of IUI cycles in the past. Medications were given to the wife for her PCOS. Self-oocytes were retrieved from the wife, and the husband's semen sample was washed with the semen washing method (density gradient (DG) and swim up). By confirming in the sample that HIV is not present, ICSI was done. Three blastocyst stage embryos were transferred on day 6 of progesterone. After 14 days, the test report of the βhuman chorionic gonadotropin (hCG) hormone came positive. Around 39 weeks later, she successfully delivered a baby boy who was later tested for HIV, and the report was negative.

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Section: Introductionmentioning

confidence: 99%

A Successful Pregnancy Outcome in a Human Immunodeficiency Virus Serodiscordant Couple in a Single Cycle of In Vitro Fertilization/Intracytoplasmic Sperm Injection: A Case Report

Wadkar¹,

More²

2022

Cureus

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Outcomes of assisted reproductive technologies in discordant couples with HIV infection in a woman

Mituyrina,

Perminova,

Sannikova

2023

Gynecology

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Aim. To evaluate the effectiveness of assisted reproductive technologies (art) in discordant couples with hiv-infected women. Materials and methods. The prospective clinical study included 432 women who received an in vitro fertilization (ivf) program. The main group included 214 subjects with hiv infection, and the control group included 218 subjects without hiv infection. In the main group, 182 "fresh" ivf/icsi (intracytoplasmic sperm injection) cycles and 162 cryocycles were performed; in the control group, 271 and 195 cycles, respectively. Results. The median length of HIV infection was 9.8 (5.7; 12.4) years, subclinical stage 3 of the disease prevailed (59.8%), and the duration of antiretroviral therapy was 4.5 (2.4; 8) years. The CD4+lymphocyte count [630 (496; 791) cells/μL] indicated a relatively "good" state of the immune system due to the antiretroviral therapy. In the main group, a significantly lower number of oocyte-cumulus complexes [6.5 (3; 12) and 9 (6; 15); p0.001], zygotes [4 (2; 8) and 6 (4; 10); p0.001] and blastocysts [2 (0; 2) and 4 (1; 6); p0.001] were obtained in comparison with the control group. The number of abnormally fertilized oocytes (3 or more PNs) was significantly higher in the group of HIV-infected women compared to HIV-negative ones — 0.21 (0.7) and 0.09 (0.2) (p=0.018), respectively. Evaluation of the effectiveness of "fresh" IVF/ICSI cycles showed that HIV-infected women had a significantly lower incidence of clinical pregnancy (16.5 and 32.8%; p=0.001), as well as live births (12.2 and 31.5%; p0.001). Analysis of cryocycle outcomes showed that using their own oocytes in women with HIV infection, the frequency of clinical pregnancy (27.6 and 41%; p=0.014) and childbirth (16.7 and 27.7%; p=0.021) is significantly lower than in patients without HIV infection, and in cases of using donor oocytes, these indicators are comparable between the groups (40%; p=0.910 and 25.7%; p=0.809, respectively). Conclusion. ART in HIV-infected women is associated with low pregnancy rates in both "fresh" and cryocycles using their own oocytes. The decrease in the oocytes/embryos obtained and the high proportion of abnormal fertilization in HIV-infected patients suggest the presence of oocyte factor as the main cause of the low effectiveness of ART programs in this group of patients.

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Comparison of in vitro fertilization cycles in couples with human immunodeficiency virus type 1 infection versus noninfected couples through a retrospective matched case-control study

Abstract: Objective: To compare in vitro fertilization (IVF) outcomes in couples in which at least one partner is human immunodeficiency virus (HIV) positive with that of couples in which neither partner is HIV-positive. Design: Retrospective matched case-control study.

Cited by 2 publications

References 35 publications

A Successful Pregnancy Outcome in a Human Immunodeficiency Virus Serodiscordant Couple in a Single Cycle of In Vitro Fertilization/Intracytoplasmic Sperm Injection: A Case Report

A Successful Pregnancy Outcome in a Human Immunodeficiency Virus Serodiscordant Couple in a Single Cycle of In Vitro Fertilization/Intracytoplasmic Sperm Injection: A Case Report

Outcomes of assisted reproductive technologies in discordant couples with HIV infection in a woman

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