Comparison of in vivo cardiac function with ex vivo cardiac performance of the rat heart after thoracic irradiation.

Franken, Nicolaas A.P.; Camps, Julià; Ravels, F.J.M. Van; Laarse, A. van der; Pauwels, E. K. J.; Wondergem, J.

doi:10.1259/bjr.70.838.9404203

Cited by 20 publications

(19 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A variety of acute and early biochemical changes associated with morphological damage and impairment of cardiac function mediated by irradiation have been demonstrated (Prignitz et al 1976;Lauk 1987;SchultzHector et al 1992;Franken et al 1992Franken et al , 1993Franken et al , 1997Persons et al 1996). Myocardial Na + , K + -ATPase activity was reduced within 30 min after irradiation of guinea pigs (Prignitz et al 1976).…”

Section: Discussionmentioning

confidence: 98%

“…Clinical studies have demonstrated that patients who received mediastinal irradiation for the treatment of neoplasms frequently develop cardiovascular complications long after radiotherapy (Gomez et al 1983;Morgan et al 1985;Young et al 1990). When a large portion of the heart is located in the radiation ®eld, as in the treatment of Hodgkin's disease, a dose of up to 40 Gy in 20 fractions over a 4-week period is well tolerated, but at doses above that a rapid increase in cardiac abnormalities have been reported (Stewart et al 1995).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Myocardial enzyme activities in plasma after whole-heart irradiation in rats

Franken

Strootman

Hollaar

et al. 2000

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

Plasma levels of myocardial enzymes present after local heart irradiation were studied in a rat model. The purpose was to investigate whether, within days after irradiation, these enzyme levels change to such an extent that they may be helpful in assessing the severity of cardiac damage after radiotherapy. Therefore, activities of creatine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alpha-hydroxybutyrate dehydrogenase (alpha-HBDH) were determined in the plasma and left ventricular myocardium of rats following local heart irradiation with a single dose of 20 Gy. A dose of 20 Gy is known to cause irreversible cardiac damage and to reduce survival times of the animals. Cardiac enzyme assays were performed directly after and twice daily for up to 2 weeks after radiation. Plasma CK, LDH, AST and alpha-HBDH levels were increased between 2 h and 24 h after irradiation. Plasma ALT levels remained unchanged. Myocardial enzyme levels, measured between 24 h and 16 days after radiation, did not differ between irradiated and control animals, although acute (first 12 h) reductions were observed in the irradiated group. The elevated enzyme levels in plasma appeared to correlate with the acutely reduced myocardial enzyme levels. Although irradiation with a dose of 20 Gy induced acute rises of cardiac enzyme levels in plasma, it is doubtful that fractionated radiation, as applied clinically for treatment of solid tumors, will induce plasma enzyme elevations that are large enough to indicate the extent of cardiac damage occurring acutely or chronically.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Myocardial enzyme activities in plasma after whole-heart irradiation in rats

Franken

Strootman

Hollaar

et al. 2000

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

show abstract

“…Redistribution of perfusion to, or a compensatory expansion of, previously underused alveoli may maintain an adequate gas exchange after destruction of irradiated regions (41). Also in the case of failing cardiac function, compensatory abilities have been shown either on the level of the heart itself or on the level of regulatory mechanisms of the entire cardiovascular system (42,43). Thus, it is plausible that limited damage to each of the two organs separately would remain subclinical, but its combination will exceed compensatory abilities and translate into clinically manifest symptoms.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Radiation Injury: Identification of Risk Factors Associated with Regional Hypersensitivity

Novakova-Jiresova

Luijk

Goor³

et al. 2005

Cancer Research

View full text Add to dashboard Cite

Effective radiation treatment of thoracic tumors is often limited by radiosensitivity of surrounding tissues. Several experimental studies have suggested variations in radiosensitivity of different pulmonary regions. Mice and rat studies in part contradict each other and urge for a more detailed analysis. This study was designed to obtain a more comprehensive insight in radiation injury development, expression, and its regional heterogeneity in lung. The latter is obviously highly critical for optimization of radiotherapy treatment plans and may shed light on the mechanisms of lung dysfunction after irradiation. Six different but volume-equal regions in rat lung were irradiated. Whereas the severity of damage, as seen in histologic analysis, was comparable in all regions, the degree of lung dysfunction, measured as breathing rates, largely varied. During the pneumonitic phase (early : 6-12 weeks), the most sensitive regions contained a substantial part of alveolar lung parenchyma. Also, a trend for hypersensitivity was observed when the heart lay in the irradiation field. In the fibrotic phase (late: 34-38 weeks), lung parenchyma and heartencompassing regions were the most sensitive. No impact of the heart was observed during the intermediate phase (16-28 weeks). The severity of respiratory dysfunction after partial thoracic irradiation is likely governed by an interaction between pulmonary and cardiac functional deficits. As a repercussion, more severe acute and delayed toxicity should be expected after combined lung and heart irradiation. This should be considered in the process of radiotherapy treatment planning of thoracic malignancies. (Cancer Res 2005; 65(9): 3568-76)

show abstract

“…After a single dose of 20 Gy, myocardial degeneration becomes apparent in rats at around 6 months post-irradiation and is preceded by a marked reduction in capillary density (11). Parallel to the development of morphological damage, hemodynamic studies reveal a marked impairment of cardiac function (12,13).…”

Section: Original Articlementioning

confidence: 99%