Comparison of induction characteristics of 1 percent propofol versus 2 percent propofol during induction in elective plastic surgery procedures

Abstract

Propofol is the most widely used and available agent. Due to its complex formulations many preparations of propofol existed in the market. Aim: Compare the induction characteristics of 1% propofol with 2% propofol in adults undergoing elective plastic surgery procedures. Settings and Design: Randomized double blind prospective study conducted after institutional ethics committee in our institute. Materials and Methods: We have recruited sixty adult patients of either sex and age between eighteen to sixty year for the study who were randomly allocated in to two groups. Group one (1% propofol) and group two (2% propofol) of thirty patients each. Induction characteristics like time to loss of consciousness, entropy less than forty, incidence of hypotension, bradycardia, involuntary movement as well as the total dose required was calculated in both groups. Results and Conclusion: Time to loss of verbal response and entropy less than 40 was less in the two percent propofol group. Overall incidence of hypotension was 15% but the incidence was much higher in group one 26.6% (p value < 0.05). The incidence of bradycardia was around 16%, the incidence was much more in group 1 as compared to group 2 (p <0.05).