Comparison of inflammatory cytokine profiles in plasma of patients undergoing otorhinological surgery with propofol or isoflurane anesthesia

Mazoti, Marina Ázer; Braz, Mariana Gobbo; Golim, Márjorie de Assis; Braz, Leandro Gobbo; Dias, Norimar Hernandes; Salvadori, Daisy Maria Fávero; Bráz, José Reinaldo Cerqueira; Fecchio, Denise

doi:10.1007/s00011-013-0643-y

Cited by 22 publications

(16 citation statements)

References 33 publications

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“…We have previously shown that an inflammatory response occurred earlier in patients anesthetized with isoflurane than in those anesthetized with intravenous propofol [6]. Similar to our study, occupational exposure to TCE has been reported to decrease the concentrations of the anti-inflammatory IL-10, providing evidence that TCE can be immunotoxic in humans [4].…”

Section: Discussionsupporting

confidence: 79%

Does occupational exposure to anesthetic gases lead to increase of pro-inflammatory cytokines?

et al. 2015

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Section: Discussionsupporting

confidence: 79%

Does occupational exposure to anesthetic gases lead to increase of pro-inflammatory cytokines?

et al. 2015

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“… Low range of quality score. [22] Brazil Otorhinological surgery. Minor 34 TIVA with propofol compared with inhaled anaesthesia with isoflurane.…”

Section: Resultsmentioning

confidence: 99%

“…Six studies [12] , [20] , [21] , [22] , [23] , [24] with 272 patients compared the use of TIVA to inhalational anesthesia and measured IL-6 at 12 to 24 hours after surgery ( Fig 2 , A ). On meta-analysis using a random effects model, TIVA was associated with a non-significant difference in IL-6 concentration (mean difference = − 1.35, 95% CI–7.02, 9.72, P = .75).…”

Section: Resultsmentioning

confidence: 99%

The effect of anesthesia on the postoperative systemic inflammatory response in patients undergoing surgery: A systematic review and meta-analysis

Alhayyan

McSorley

Roxburgh

et al. 2020

Surgery Open Science

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Background Surgical injury stimulates the systemic inflammatory response. The magnitude of the postoperative systemic inflammatory response has been shown to be significantly associated with short and long-term outcomes following surgery of varying severity. Different anesthetic techniques for surgery may have an impact on the postoperative systemic inflammatory response and on the rate of the postoperative infective complications. The aim of the present systematic review was to examine the relationship between perioperative anesthesia, the postoperative systemic inflammatory response and postoperative infective complications in patients undergoing surgery. Methods This was carried out using PubMed and other established databases from 1987 up to March 2018. In particular, randomized controlled studies and systemic inflammation markers, interleukin 6 and C-reactive protein were examined. Results Overall, 60 controlled, randomized clinical trials were included in the review. The mean or median values of both interleukin 6 and C-reactive protein were taken for each study and the mean value was calculated for each anesthetic group at sampling points of 12–24 and 24–72 hours for interleukin 6 and C-reactive protein respectively. When taking the magnitude of surgery into account, TIVA using propofol was significantly associated with a reduction in particular C-reactive protein ( P = .04). However, there were no other specific anesthetic methods including general, regional and combined anesthetics that were associated with a reduction in either interleukin 6 or C-reactive protein. Conclusion There is some evidence that anesthetic regimens may reduce the magnitude of the postoperative systemic inflammatory response. However, the studies were heterogeneous and generally of low quality. Future, well conducted, adequately powered studies are required to clarify the effect of anesthesia on the postoperative systemic inflammatory response and infective complications.

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“…Interestingly, an inflammatory response occurred earlier in patients who received isoflurane compared with propofol anesthesia. 30 Moreover, like propofol, γ-tocopherol reduces inflammation through inhibition of cyclooxygenase type 2 activity. 31 …”

Section: Discussionmentioning

confidence: 99%

Isoflurane and Propofol Contribute to Increasing the Antioxidant Status of Patients During Minor Elective Surgery

Braz

Freire

et al. 2015

Medicine

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Isoflurane is a volatile halogenated anesthetic used especially for anesthesia maintenance whereas propofol is a venous anesthetic utilized for anesthesia induction and maintenance, and reportedly an antioxidant. However, there are still controversies related to isoflurane-induced oxidative stress and it remains unanswered whether the antioxidant effects occur in patients under propofol anesthesia.Taking into account the importance of better understanding the role of anesthetics on oxidative stress in anesthetized patients, the present study was designed to evaluate general anesthesia maintained with isoflurane or propofol on antioxidant status in patients who underwent minimally invasive surgeries.We conducted a prospective randomized trial in 30 adult patients without comorbidities who underwent elective minor surgery (septoplasty) lasting at least 2 h admitted to a Brazilian tertiary hospital.The patients were randomly allocated into 2 groups, according to anesthesia maintenance (isoflurane, n = 15 or propofol, n = 15). Peripheral blood samples were drawn before anesthesia (baseline) and 2-h after anesthesia induction.The primary outcomes were to investigate the effect of either isoflurane or propofol anesthesia on aqueous plasma oxidizability and total antioxidant performance (TAP) by fluorometry as well as several individual antioxidants by high-performance liquid chromatography. As secondary outcome, oxidized genetic damage (7,8-dihydro-8-oxoguanine, known as 8-oxo-Gua) was investigated by the comet assay.Both anesthesia techniques (isoflurane or propofol) for a 2-h period resulted in a significant decrease of plasma α-tocopherol, but not other antioxidants including uric acid, carotenoids, and retinol (P > 0.05). Propofol, in contrast to isoflurane anesthesia, significantly increased (P < 0.001) anti-inflammatory/antioxidant plasma γ-tocopherol concentration in patients. Both anesthesia types significantly enhanced hydrophilic antioxidant capacity and TAP, with no significant difference between them, and 8-oxo-Gua remained unchanged during anesthesia in both groups. In addition, both anesthetics showed antioxidant capacity in vitro.This study shows that anesthesia maintained with either propofol or isoflurane increase both hydrophilic and total antioxidant capacity in plasma, but only propofol anesthesia increases plasma γ-tocopherol concentration. Additionally, both types of anesthetics do not lead to oxidative DNA damage in patients without comorbidities undergoing minimally invasive surgery.

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Comparison of inflammatory cytokine profiles in plasma of patients undergoing otorhinological surgery with propofol or isoflurane anesthesia

Cited by 22 publications

References 33 publications

Does occupational exposure to anesthetic gases lead to increase of pro-inflammatory cytokines?

Does occupational exposure to anesthetic gases lead to increase of pro-inflammatory cytokines?

The effect of anesthesia on the postoperative systemic inflammatory response in patients undergoing surgery: A systematic review and meta-analysis

Isoflurane and Propofol Contribute to Increasing the Antioxidant Status of Patients During Minor Elective Surgery

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