Comparison of injectable trace minerals vs. adjuvant on measures of innate and humoral immune responses of beef heifers

Caramalac, L. S.; Moriel, Philipe; Ranches, Juliana; Silva, G.M.; Arthington, J. D.

doi:10.1016/j.livsci.2021.104665

Cited by 3 publications

(4 citation statements)

References 28 publications

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“…However, no treatment effects (P = 0.52) were observed for Hp concentration. Our results are consistent with Caramalac et al ( 2021), who observed no differences in Hp concentration between ITM and saline treated feedlot heifers challenging with porcine red blood cells concurrent with ITM administration [30]. CRP is a moderate acute phase protein in cattle [38] that is also elevated in cattle experiencing BRD [39].…”

Section: Induction Of Acute Phase Response Proteins Following M Haemo...supporting

confidence: 92%

“…In our previous work, ITM injection improved liver Cu and Se concentrations in feedlot steers for at least 29 days compared to saline-treated controls [28]. Similarly, [27] observed improved liver Cu and Se in ITM-injected animals for at least 15 days, while [30] observed increased Se concentrations in liver for 15 days but no effects on liver Cu. Palomares et al observed that administration of ITM increased liver Se (on days 21 and 56), Cu (on day 56), and Mn (on day 56) compared to saline injections [6].…”

Section: Plasma and Liver Trace Mineral Concentrations In Steers Rece...mentioning

confidence: 64%

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Impact of an Injectable Trace Mineral Supplement on the Immune Response and Outcome of Mannheimia haemolytica Infection in Feedlot Cattle

Hong,

Rients,

Franco

et al. 2024

Biol Trace Elem Res

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The study aimed to assess the impact of injectable trace mineral (“ITM”; Multimin90; Fort Collins, CO) supplementation on bacterial infection in cattle. Angus-crossbred steers (n = 32) were organized into two blocks by initial body weight. Steers were maintained on a ryelage and dry-rolled corn-based growing diet without supplementation of Zn, Cu, Mn, and Se for the duration of the study. The steers were transported 6 h, then randomized into three treatment groups: control received sterile saline (“CON”), ITM administered 1 day after transport (6 days before infection, “ITMPRE”), and ITM administered 2 days post infection (dpi) concurrent with antibiotic treatment (“ITMPOST”). Steers were infected with Mannheimia haemolytica on day 0, and all were treated with tulathromycin at 2 dpi. Plasma levels of Zn, Cu, and Se did not differ among treatments (P ≥ 0.74). Liver Se was higher in ITMPRE at 2 dpi (P < 0.05), and both ITM groups had higher liver Se at 5 dpi (P < 0.05) compared to CON. A time × treatment interaction was detected for liver Cu (P = 0.02). Clinical scores were lower (P < 0.05) in ITMPRE on 1 and 8 dpi and ITMPOST on 8 dpi compared to CON. Thoracic ultrasonography scores were lower in ITMPRE at 2 dpi compared to CON (P < 0.05) and ITMPOST (P < 0.1). No treatment effects (P > 0.10) were observed for bacterial detection from bronchoalveolar lavage (BAL) or nasopharyngeal swabs. At 5 dpi, both ITMPRE and ITMPOST showed higher frequencies of γδ T cells and NK cells in BAL compared to CON (P < 0.05). Before infection, leukocytes from ITMPRE steers produced more IL-6 (P < 0.01) in response to stimulation with the TLR agonist, Pam3CSK4. Use of ITM may be an effective strategy for improving disease resistance in feedlot cattle facing health challenges.

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Section: Induction Of Acute Phase Response Proteins Following M Haemo...supporting

confidence: 92%

Section: Plasma and Liver Trace Mineral Concentrations In Steers Rece...mentioning

confidence: 64%

Impact of an Injectable Trace Mineral Supplement on the Immune Response and Outcome of Mannheimia haemolytica Infection in Feedlot Cattle

Hong,

Rients,

Franco

et al. 2024

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…As mentioned previously, calves were under minor management and environmental stressors therefore may not requiring to develop a strong response to these stressors. Others have reported similar response where ceruloplasmin and haptoglobin concentrations were unaffected by ITM administration ( Genther and Hansen, 2014 ; Caramalac et al, 2021 ), while Arthington et al (2014) reported increased concentration of ceruloplasmin and haptoglobin concentrations for heifers administered ITM prior to weaning and transport, however the authors associated this increase in the acute-phase proteins, especially ceruloplasmin, to the greater trace mineral status of those calves, which was not observed in the current study.…”

Section: Discussioncontrasting

confidence: 47%

“…Similarly, calves born to these dams received an ITM injection at birth and at breeding (calves: 1.0 mL/45 kg BW); 2) Control: primiparous cows assigned to the control treatment followed the same procedure as the cattle assigned to the ITM treatment, however, these primiparous cows and calves were injected with saline solution at calving/birth and at breeding. Saline injections were administered to cows assigned to control treatment to ensure that all animals were treated similarly, and to avoid in any possible site reaction differences between treatments ( Caramalac et al, 2021 ). The ITM utilized contained 60, 10, and 15 mg/mL of Zn, Mn, and Cu, as disodium EDTA chelates, and 5 mg/mL of Se, as sodium selenite.…”

Section: Methodsmentioning

confidence: 99%

Effects of Trace Mineral Injections on Measures of Growth and Trace Mineral Status of Primiparous Cows and their Calves

Hernandez,

Ferreira,

Santos

et al. 2024

Translational Animal Science

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The objective of this study was to evaluate the effects of injectable trace minerals (ITM) administrations at strategic moments in the beef cattle production cycle. At calving, 50 primiparous cows (Angus × Hereford) and their calves were randomly assigned to 1 of 2 treatments: 1) Injectable trace minerals (ITM): cattle assigned to the ITM treatment received an ITM injection at calving and a subsequent administration at breeding (cattle over 2 years: 1.0 ml/90 kg BW; calves: 1.0 ml/45 kg BW); or 2) Control: cattle assigned to the Control treatment, were administrated with saline following the same procedure as the cattle assigned to the ITM treatment. Body weight, blood, and liver samples were collected from dams and calves at multiple time points to evaluate the growth and mineral status of cow-calf pairs. All variables were analyzed using the MIXED procedure of SAS. A treatment effect (P = 0.02) was observed for Cu liver concentration of primiparous cows at breeding. Cows assigned to ITM treatment had greater Cu status than cohorts assigned to Control treatment. No treatment effects were observed for the mineral status or growth of calves. The administration of ITM to primiparous cows enhanced Cu status when grazing Cu forages scarce of Cu.

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Impact of a trace mineral injection at weaning on growth, behavior, and inflammatory, antioxidant, and immune responses of beef calves

Vedovatto,

Ferreira,

Edwards

et al. 2024

Translational Animal Science

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Two experiments evaluated the effects of an injectable trace mineral (ITM) solution at weaning on trace mineral (TM) status, inflammatory and antioxidant responses, grazing behavior, response to vaccination, and growth of beef calves. Exp. 1 used 86 Nellore calves [40 females and 46 males; body weight (BW) = 198 ± 30.8 kg; 8 ± 1 mo of age] weaned (d 0) and assigned into 1 of 2 treatments: Saline (0.9% NaCl) or ITM (60 mg of Zn/mL, 15 mg of Cu/mL, 5 mg of Se/mL and 10 mg of Mn/mL). Saline and ITM were administered subcutaneously at a dose of 1 mL/45 kg of BW. On d 0, calves were vaccinated against infectious bovine rhinotracheitis (IBR), parainfluenza-3 (PI3), bovine viral diarrhea virus type 1 and 2 (BVDV-1 and 2) and bovine respiratory syncytial virus (BRSV). Blood samples and BW were collected on d 0, 3, 8, 15, 51, and 100, and grazing behavior was evaluated on d 1, 2, 4, 5, 6, 7, and 9. The ITM did not affect (P ≥ 0.56) serum mineral concentrations of Zn and Cu, but decreased (P ≤ 0.02) plasma concentrations of cortisol on d 3 and 8 and haptoglobin on d 3. The ITM increased (P < 0.01) plasma concentration of superoxide dismutase on d 8, 15, and 51 and tended to decrease (P = 0.08) plasma concentration of glutathione peroxidase on d 3. Furthermore, there were no effects of treatment (P ≥ 0.14) on most of the behavior variables evaluated, ITM reduced (P = 0.01) the seeking time on d 0 and 4. Furthermore, ITM tended to increase (P = 0.10) the serum titer concentration against IBR on d 15 and 51 but did not affect (P ≥ 0.12) titer concentration against PI3, BVDV-1, and 2, and growth. Exp. 2 used 50 Brangus male calves (BW = 264 ± 34.1 kg; 8 ± 1 mo of age] weaned on d 0, vaccinated against respiratory diseases, stratified by BW, and randomly assigned to Saline or ITM as described in Exp. 1. Liver samples were collected on d 0, 14 and 197, blood samples on d 0, 14 and BW on d 0, 14, 44, 78, 122, 162 and 197. The ITM increased (P ≤ 0.03) the liver concentration of Cu and Se on d 14 but did not affect (P ≥ 0.17) the liver concentration of Zn and Mn. In addition, ITM increased (P = 0.05) the serum titer concentration against BVDV-2 but did not affect (P ≥ 0.20) the titer concentrations against IBR, PI3, BVDV-1, and BRSV, and did not affect (P ≥ 0.29) the growth. In conclusion, ITM application at weaning improved Cu and Se status, enhanced antioxidant and immune responses, and reduced stress and inflammation in calves, though it did not affect growth.

show abstract

Comparison of injectable trace minerals vs. adjuvant on measures of innate and humoral immune responses of beef heifers

Cited by 3 publications

References 28 publications

Impact of an Injectable Trace Mineral Supplement on the Immune Response and Outcome of Mannheimia haemolytica Infection in Feedlot Cattle

Impact of an Injectable Trace Mineral Supplement on the Immune Response and Outcome of Mannheimia haemolytica Infection in Feedlot Cattle

Effects of Trace Mineral Injections on Measures of Growth and Trace Mineral Status of Primiparous Cows and their Calves

Impact of a trace mineral injection at weaning on growth, behavior, and inflammatory, antioxidant, and immune responses of beef calves

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