Comparison of Injection Comfort of a New Category of Cohesive Hyaluronic Acid Filler With Preincorporated Lidocaine and a Hyaluronic Acid Filler Alone

Levy, Phillip M.; Boulle, Koenraad De; Raspaldo, Hervé

doi:10.1111/j.1524-4725.2008.01045.x

Cited by 36 publications

(35 citation statements)

References 10 publications

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“…Thus, even if the charge interaction is one of the reasons for using the polyelectrolyte HA as a delivery vehicle [25], in our case, the large difference in molecular weight masked the influence of the charge interaction, confirming the major effects of molecular weight on drug release from a hydrogel [27]. The rapid in vitro release of lidocaine from the studied hydrogels is also consistent with the clinical observations, i.e., reduced pain during and after the administration of HA fillers containing lidocaine compared to fillers without lidocaine [28,29]. Notably, differences in the macrostructures of the three tested hydrogels did not affect drug release of both drugs.…”

Section: Discussionsupporting

confidence: 77%

Influence of the Macro- and/or Microstructure of Cross-Linked Hyaluronic Acid Hydrogels on the Release of Two Model Drugs

Mondon¹,

Dadras²

2016

J Glycobiol

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Injectable hyaluronic acid (HA) hydrogels, crosslinked with 1,4-butanediol diglycidyl ether (BDDE), are widely used in aesthetic medicine. Due to their high clinical tolerance, HA hydrogels are thought to be applicable as injectable drug delivery systems. Here, HA matrix structures of BDDE-crosslinked HA hydrogels were analysed, and the effects of the structures on the release of two model drugs were assessed. Seven crosslinked HA hydrogels were observed by optical microscopy and cryo scanning electron microscopy (cryo-SEM). We observed three specific matrix macrostructures under optical microscopy: two had a "spider web"-like structure, three had a particulate structure, and two had an intermediate structure. These differences were less evident under cryo-SEM, where all hydrogels exhibited fibrous microstructures of different homogeneity levels, with pore sizes between 0.5 and 18 μm. Three cross-linked HA hydrogels with different macrostructures were loaded with bovine serum albumin (BSA) and lidocaine to assess their capacities to release drug over 4 days. No differences in drug release were observed between gels, and BSA was released for up to 4 days, which was four times longer than lidocaine. Thus, BDDEcrosslinked HA hydrogels could be applied as an injectable drug delivery system, particularly for the delivery of high-molecular-weight molecules.

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Section: Discussionsupporting

confidence: 77%

Influence of the Macro- and/or Microstructure of Cross-Linked Hyaluronic Acid Hydrogels on the Release of Two Model Drugs

Mondon¹,

Dadras²

2016

J Glycobiol

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“…Studies and the authors' experience have shown that the incorporation of lidocaine into dermal fillers significantly reduces pain and discomfort [62][63][64].…”

Section: Dermal Fillers With Lidocainementioning

confidence: 99%

Dermal Fillers: An Update

2015

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Injection of dermal fillers is the second most frequent nonsurgical cosmetic procedure performed in the USA. Dermal fillers are an option in the treatment of volume deficiency, scars, and rhytides; facial sculpting; facial contouring; and augmentation of specific anatomical sites such as the lips. The number of injectable dermal fillers available on the market increases yearly. Dermatologists and cosmetic surgeons should regularly review treatment options to provide patients with safe and effective filler options. This paper extensively reviews the properties of the available fillers, such as their rheology, longevity, and adverse effects, and how these properties affect the choice of filler agent for a particular patient or a particular site. Also, trends in dermal filler injections are discussed.

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“…Recent studies have shown that the use of pre-incorporated lidocaine in HA fillers greatly increases patient comfort during the procedure [6].…”

Section: 5 Million Reportedmentioning

confidence: 99%

Fillers and Botulinum Toxins

2010

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Comparison of Injection Comfort of a New Category of Cohesive Hyaluronic Acid Filler With Preincorporated Lidocaine and a Hyaluronic Acid Filler Alone

Abstract: The smooth, cohesive HA gel with preincorporated lidocaine increased subject comfort during treatment and improved the injection experience.

Cited by 36 publications

References 10 publications

Influence of the Macro- and/or Microstructure of Cross-Linked Hyaluronic Acid Hydrogels on the Release of Two Model Drugs

Influence of the Macro- and/or Microstructure of Cross-Linked Hyaluronic Acid Hydrogels on the Release of Two Model Drugs

Dermal Fillers: An Update

Fillers and Botulinum Toxins

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