Comparison of Injection Sclerotherapy Between 5% Phenol in Almond Oil and Aluminum Potassium Sulfate and Tannic Acid for Grade 3 Hemorrhoids

Yano, Takaaki; Yano, Kenji

doi:10.3393/ac.2015.31.3.103

Cited by 29 publications

(18 citation statements)

References 5 publications

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“…The satisfactory results obtained in phlebology [7,8] have recently led to the use of several sclerosing agents [9][10][11] for the treatment of HD.…”

Section: Introductionmentioning

confidence: 99%

Short-Term Results of Sclerotherapy with 3% Polidocanol Foam for Symptomatic Second- and Third-Degree Hemorrhoidal Disease

Lobascio

Laforgia

Novelli³

et al. 2020

Journal of Investigative Surgery

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Background: Hemorrhoidal disease (HD) is defined as the symptomatic enlargement and/or distal displacement of anal cushions and is one of the most common proctological diseases. Sclerotherapy (ST) with 3% polidocanol foam induces an inflammatory reaction with sclerosis of the submucosal tissue and consequent suspension of the hemorrhoidal tissue. The aim of this study was to evaluate the short-term effectiveness and safety of ST with 3% polidocanol foam for the treatment of symptomatic second-and third-degree HD. Methods: A total of 66 patients with symptomatic second-and third-degree HD underwent a single ST session between March 2017 and July 2018. A visual analog scale score was used to assess post-operative pain and patient satisfaction. The symptoms severity and anal continence were investigated through the Hemorrhoid Severity Score (HSS) and Vaizey score, respectively, at baseline, at 4 weeks and after 1 year. Results: Fifty-seven out of 66 patients were male (86.3%), and the mean age was 52 (29-75; SD ± 12) years. The mean operative time was 4.5 (2-6; SD ± 1.23) minutes. No intraoperative complications and no drug-related side effects occurred. The overall success rate was 78.8% (52/66 patients) after a single ST session and 86% after two ST sessions (57/66 patients). The mean treatment effect, obtained comparing preoperative and 12 months symptom scores in each patient, showed a median change of 8 (p < 0.001). All patients resumed their normal daily activities the day after the procedures. Conclusions: ST with 3% polidocanol foam is a safe, cost-effective and repeatable conservative treatment.

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“…The satisfactory results obtained in phlebology [7,8] have recently led to the use of several sclerosing agents [9][10][11] for the treatment of HD.…”

Section: Introductionmentioning

confidence: 99%

Short-Term Results of Sclerotherapy with 3% Polidocanol Foam for Symptomatic Second- and Third-Degree Hemorrhoidal Disease

Lobascio

Laforgia

Novelli³

et al. 2020

Journal of Investigative Surgery

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show abstract

“…Injection sclerotherapy for haemorrhoids involves 5% phenol dissolved in almond oil (PAO). Potassium aluminium sulphate and tannic acid (ALTA) are used as additives (Yano and Yano 2015;Acheson and Scholefield 2008). A classical usage of phenolics is to treat warts and verrucas (Dalimunthe et al 2018).…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Finding possible pharmacological effects of identified organic compounds in medicinal waters (BTEX and phenolic compounds)

Szabó

Varga

2019

Int J Biometeorol

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Medicinal thermal waters consist of a mixture of different organic and inorganic compounds. Traditionally, these waters are only characterized and classified by their inorganic composition; however, the bioavailability of the majority of these inorganic compounds is limited. Many authors investigate the organic fractions of thermal waters. These authors propose that these compounds have a potential effect on health. To elucidate the underlying mechanisms, it is crucial to know the composition of the organic fractions. The absorption of these compounds on intact skin or mucosa is notable. Some of them have local anaesthetic effect or affect receptors in the central nervous system. In the knowledge of the chemical composition, we are able to estimate the possible pharmacological effect or might be able to assess possible toxicity risks. In the present article, we aim to review possible health effects of two of the identified organic fractions: benzene and alkylbenzenes and phenolic compounds that might correlate with the therapeutic effect on rheumatological or other diseases.

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“…The mousse was obtained following the Moser technique [10], and the amount of foam injected for each single pile was 2 mL of 3% polidocanol. Before each injection, the foam already obtained was reemulsified for 20 seconds.…”

Section: Techniquementioning

confidence: 99%

Short-term Results Of Sclerotherapy With 3% Polidocanol Foam For Symptomatic Second- And Third-degree Haemorrhoidal Disease

Lobascio

Laforgia

Novelli³

et al. 2019

Preprint

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Background.Haemorrhoidal disease (HD) is defined as the symptomatic enlargement and/or distal displacement of anal cushions and is one of the most common proctological diseases. Sclerotherapy (ST) with 3% polidocanol foam induces an inflammatory reaction with sclerosis of the submucosal tissue and consequent suspension of the haemorrhoidal tissue. The aim of this study was to evaluate the short-term effectiveness and safety of ST with 3% polidocanol foam for the treatment of symptomatic second-and third-degree HD.Methods.A total of 66 patients with symptomatic second-and third-degree HD underwent a single ST session between March 2017 and July 2018. A visual analogue scale score was used to assess postoperative pain and patient satisfaction. The symptoms severity and anal continence were investigated through a self-reported questionnaire and Vaizey score, respectively, at baseline, at 4 weeks and after 1 year.Results. Fifty-seven out of 66 patients were male (86.3%), and the mean age was 52 (29-75; SD ± 12) years. The mean operative time was 4.5 (2-6; SD ± 1.23) minutes. No intraoperative complications and no drug-related side effects occurred. The overall success rate was 78.8% (52/66 patients) after a single ST session and 86% after two ST sessions (57/66 patients). The mean treatment effect, obtained comparing preoperative and T5 symptom scores in each patient, showed a mean change of 7.88 (p<0.001). All patients resumed their normal daily activities the day after the procedures.Conclusions.ST with 3% polidocanol foam is a safe, cost-effective and repeatable conservative treatment.

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Comparison of Injection Sclerotherapy Between 5% Phenol in Almond Oil and Aluminum Potassium Sulfate and Tannic Acid for Grade 3 Hemorrhoids

Cited by 29 publications

References 5 publications

Short-Term Results of Sclerotherapy with 3% Polidocanol Foam for Symptomatic Second- and Third-Degree Hemorrhoidal Disease

Short-Term Results of Sclerotherapy with 3% Polidocanol Foam for Symptomatic Second- and Third-Degree Hemorrhoidal Disease

Finding possible pharmacological effects of identified organic compounds in medicinal waters (BTEX and phenolic compounds)

Short-term Results Of Sclerotherapy With 3% Polidocanol Foam For Symptomatic Second- And Third-degree Haemorrhoidal Disease

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