Comparison of insulin resistance-associated parameters in US adults: a cross-sectional study

Yan, Shaoyi; Wang, Di; Jia, Yongping

doi:10.1007/s42000-023-00448-4

Cited by 29 publications

(12 citation statements)

References 35 publications

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“…Obesity may also contribute to the development of cardiovascular disease and death from cardiovascular disease independently of other cardiovascular risk factors, especially the location of body fat distribution [ 41 , 42 ]. Furthermore, integrating TyG with obesity indices presents a more accurate insulin resistance evaluation than the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) or TyG index alone [ 3 , 21 , 22 , 27 ]. Our results provide significant proof for the literature on TyG, TyG-BMI, TyG-WC, and TyG-WHtR as predictors of cardiovascular disease risk.…”

Section: Discussionmentioning

confidence: 99%

“…Obesity is prevalent worldwide and is closely associated with various health risks, such as poor glucose tolerance, insulin resistance, and metabolic disorders [ 15 – 17 ], which can lead to the onset progression and prognosis of cardiovascular disease [ 18 – 20 ]. TYG combined with obesity indices is closely associated with insulin resistance [ 21 , 22 ], metabolic syndrome [ 23 ], uric acid [ 24 ], diabetes mellitus [ 25 ], and fatty liver [ 26 ]. Some studies have shown that TyG combined with adiposity indices is better than the TyG index for assessing [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

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The association between triglyceride-glucose index and its combination with obesity indicators and cardiovascular disease: NHANES 2003–2018

Dang,

Wang,

et al. 2024

Cardiovasc Diabetol

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Background In the American population, the relationship between the triglyceride-glucose (TyG) index and TYG combined with indicators of obesity and cardiovascular disease (CVD) and its mortality has been less well studied. Methods This cross-sectional study included 11,937 adults from the National Health and Nutrition Examination Survey (NHANES) 2003–2018. Cox proportional hazards model, binary logistic regression analyses, restricted cubic spline (RCS), and receiver operating characteristic (ROC) were used to analyze the relationship between TyG and its combined obesity-related indicators and CVD and its mortality. Mediation analysis explored the mediating role of glycated hemoglobin and insulin in the above relationships. Results In this study, except for no significant association between TyG and CVD mortality, TyG, TyG-WC, TyG-WHtR, and TyG-BMI were significantly and positively associated with CVD and CVD mortality. TyG-WHtR is the strongest predictor of CVD mortality (HR 1.66, 95% CI 1.21–2.29). The TyG index correlated better with the risk of coronary heart disease (OR 2.52, 95% CI 1.66–3.83). TyG-WC correlated best with total CVD (OR 2.37, 95% CI 1.77–3.17), congestive heart failure (OR 2.14, 95% CI 1.31–3.51), and angina pectoris (OR 2.38, 95% CI 1.43–3.97). TyG-WHtR correlated best with myocardial infarction (OR 2.24, 95% CI 1.45–3.44). RCS analyses showed that most of the above relationships were linear (P-overall < 0.0001, P-nonlinear > 0.05). Otherwise, ROC curves showed that TyG-WHtR and TyG-WC had more robust diagnostic efficacy than TyG. In mediation analyses, glycated hemoglobin mediated in all the above relationships and insulin-mediated in partial relationships. Conclusions TyG-WC and TyG-WtHR enhance CVD mortality prediction, diagnostic efficacy of CVD and its mortality, and correlation with some CVD over and above the current hottest TyG. TyG-WC and TyG-WtHR are expected to become more effective metrics for identifying populations at early risk of cardiovascular disease and improve risk stratification.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association between triglyceride-glucose index and its combination with obesity indicators and cardiovascular disease: NHANES 2003–2018

Dang,

Wang,

et al. 2024

Cardiovasc Diabetol

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“…The novel index constructed by TyG in combination with body measurements, compared with TyG alone, has shown better diagnostic value for multiple diseases [ 61 , 62 ]. In addition, TyG in combination with body measurements is more accurate in evaluating IR than TyG alone [ 63 – 66 ]. Although studies exploring the connection between TyG-associated indices and frailty are limited, a relationship between them appears reasonable.…”

Section: Discussionmentioning

confidence: 99%

Association of the triglyceride-glucose index and its related parameters with frailty

Yin,

Guo,

Zhu

et al. 2024

Lipids Health Dis

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Background Frailty is a dynamic geriatric condition. Limited studies have examined the association of the triglyceride-glucose (TyG) index and its related indicators [TyG index, triglyceride glucose-waist to height ratio (TyG-WHtR), triglyceride glucose-waist circumference (TyG-WC), and triglyceride glucose-body mass index (TyG-BMI)] with frailty, and the potential links among them remain unclear. On the basis of data from the National Health and Nutrition Examination Survey (NHANES), this study investigated the potential relationships of the TyG index and its related indices with frailty. Methods This research included 7,965 participants from NHANES 2003–2018. The relationship of the TyG index and its related indices with frailty was investigated with binary logistic regression analyses, restricted cubic spline (RCS), and receiver operating characteristic (ROC) curve. Potential influences were further investigated through stratified analyses and interaction tests. Results The prevalence of frailty in the participants of this study was 25.59%, with a average frailty index of 0.16 (0.00). In the three regression analysis models, the continuous TyG index and its associated indices were positively associated with frailty. In addition, quartiles of TyG, TyG-WC, TyG-WHtR, and TyG-BMI were significantly associated with increased frailty prevalence in the fully adjusted models (TyG Q4 vs. Q1, OR = 1.58, 95% CI: 1.19, 2.09, P = 0.002; TyG-WC Q4 vs. Q1, OR = 2.40, 95% CI: 1.90, 3.04, P < 0.001; TyG-WHtR Q4 vs. Q1, OR = 2.26, 95% CI: 1.82, 2.81, P < 0.001; TyG- BMI Q4 vs. Q1, OR = 2.16, 95% CI: 1.76, 2.64, P < 0.001). According to RCS analysis, TyG, TyG-WC, TyG-WHtR, and TyG-BMI were linearly and positively associated with frailty. ROC curves revealed that TyG-WHtR (AUC: 0.654) had greater diagnostic value for frailty than TyG (AUC: 0.604), TyG-BMI (AUC: 0.621), and TyG-WC (AUC: 0.629). All of the stratified analyses and interaction tests showed similar results. Conclusions Elevated TyG and its associaed indices are associated with an increased prevalence of frailty. Reasonable control of blood glucose and blood lipids, and avoidance of obesity, may aid in reducing the occurrence of frailty in middle-aged and older adults.

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“…Among the possible reasons, obesity can contribute directly to the development of stroke risk factors, including insulin resistance, abnormal glucose/lipid metabolism, hypertension, a pro-inflammatory and pro-thrombotic state, endothelial dysfunction [40,41]. Furthermore, integrating TyG with obesity indices presents a more accurate insulin resistance evaluation than the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) or TyG index alone [42,43]. Our results provide significant proof for the literature on TyG, TyG-BMI, TyG-WC, and TyG-WHtR as predictors of stroke risk.…”

Section: Mediation Analysis Of Tyg Tyg-wc Tyg-whtr and Tyg-bmi With S...mentioning

confidence: 99%

The association between triglyceride-glucose index and its combination with obesity indicators and stroke: CHARLS 2011-2020

LIANG,

OUYANG

2024

Preprint

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Background In the Chinese population, limited research has been conducted on the association between the triglyceride-glucose (TyG) index and its combination with obesity indicators in relation to stroke and its mortality. Methods This study enrolled a total of 8,207 participants from the China Health and Retirement Longitudinal Study (CHARLS) 2011–2020. Cox proportional hazards model, restricted cubic spline (RCS) and receiver operating characteristic (ROC) analysis were employed to examine the association between the triglyceride-glucose (TyG) index and its combined obesity-related indicators with stroke and its mortality. Mediation analysis was conducted to explore the mutual potential mediating role of TyG and obesity indicators in the above relationships. Results In this study, TyG, TyG-BMI, TyG-WHtR, and TyG-WC were significantly and positively associated with stroke and its mortality. Restricted cubic spline models revealed nonlinear associations between TyG and TyG-BMI with stroke risk, while TyG-WC and TyG-WHtR demonstrated linear associations with stroke mortality after adjusting for relevant covariates. TyG-WHtR, TyG-BMI and TyG-WC had more robust diagnostic efficacy than TyG for risk of stroke. TyG-WHtR or TyG-WC had the highest diagnostic efficacy for stroke and its mortality (AUC:0. 696, 95% CI 0.677–0.715), slightly higher than the other indicators. Associations between TyG, TyG-WC, TyG-WHtR, and TyG-BMI with stroke were found to be stronger among individuals who were ≥ 55 years of age, male. The relationship between TyG and stroke is partially mediated by obesity measures, while the relationship between obesity measures and stroke is partially mediated by TyG. Conclusion Compared with the traditional single TyG, the combination of TyG and obesity indicators could improve the prognostic accuracy of stroke mortality, enhance diagnostic efficacy for stroke and its mortality, and uncover additional associations with stroke. These findings carry noteworthy implications for the timely identification of individuals at risk of stroke, and refining risk stratification.

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Comparison of insulin resistance-associated parameters in US adults: a cross-sectional study

Cited by 29 publications

References 35 publications

The association between triglyceride-glucose index and its combination with obesity indicators and cardiovascular disease: NHANES 2003–2018

The association between triglyceride-glucose index and its combination with obesity indicators and cardiovascular disease: NHANES 2003–2018

Association of the triglyceride-glucose index and its related parameters with frailty

The association between triglyceride-glucose index and its combination with obesity indicators and stroke: CHARLS 2011-2020

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